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Literature summary for 4.1.99.17 extracted from

  • Chatterjee, A.; Hazra, A.B.; Abdelwahed, S.; Hilmey, D.G.; Begley, T.P.
    A "radical dance" in thiamin biosynthesis: mechanistic analysis of the bacterial hydroxymethylpyrimidine phosphate synthase (2010), Angew. Chem. Int. Ed. Engl., 49, 8653-8656.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 4.1.99.17

Metals/Ions

Metals/Ions Comment Organism Structure
iron-sulfur centre
-
 Bacteria

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
5-amino-1-(5-phospho-D-ribosyl)imidazole + S-adenosyl-L-methionine Bacteria the enzyme is involved in thiamine biosynthesis 4-amino-2-methyl-5-phosphomethylpyrimidine + 5'-deoxyadenosine + L-methionine + formate + CO
-
 ?

Organism

Organism UniProt Comment Textmining
Bacteria
-
-
-

Reaction

Reaction Comment Organism Reaction ID
5-amino-1-(5-phospho-D-ribosyl)imidazole + S-adenosyl-L-methionine = 4-amino-2-methyl-5-(phosphooxymethyl)pyrimidine + 5'-deoxyadenosine + L-methionine + formate + CO mechanistic analysis Bacteria
a

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
5-amino-1-(5-phospho-D-ribosyl)imidazole + S-adenosyl-L-methionine the enzyme is involved in thiamine biosynthesis Bacteria 4-amino-2-methyl-5-phosphomethylpyrimidine + 5'-deoxyadenosine + L-methionine + formate + CO
-
 ?
5-amino-1-(5-phospho-D-ribosyl)imidazole + S-adenosyl-L-methionine mechanistic analysis Bacteria 4-amino-2-methyl-5-phosphomethylpyrimidine + 5'-deoxyadenosine + L-methionine + formate + CO
-
 ?

General Information

General Information Comment Organism
physiological function the enzyme is involved in thiamine biosynthesis Bacteria