4.1.99.12: 3,4-dihydroxy-2-butanone-4-phosphate synthase
This is an abbreviated version!
For detailed information about 3,4-dihydroxy-2-butanone-4-phosphate synthase, go to the full flat file.
Word Map on EC 4.1.99.12
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4.1.99.12
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disinfection
-
trihalomethanes
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haloacetic
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brominate
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halogen
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haloacetonitriles
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chloramination
-
bromide
-
genotoxicity
-
chloroform
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effluent
-
wastewater
-
iodin
-
ozone
-
swimming
-
humic
-
unregulated
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trichloronitromethane
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n-nitrosodimethylamine
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carbonaceous
-
chloral
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speciation
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dichloroacetic
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dichloroacetonitrile
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monochloramine
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haloketones
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bromodichloromethane
-
swimmers
-
fulvic
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hypochlorite
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non-regulated
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micropollutants
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clo2
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pilot-scale
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n-nitrosamines
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naclo
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excitation-emission
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bromoacetic
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chlorite
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ballast
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shower
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acid-like
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pipe
-
potable
-
suwannee
-
drug development
-
synthesis
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nanofiltration
-
biofiltration
-
bromoform
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indoor
-
iodate
- 4.1.99.12
-
disinfection
-
trihalomethanes
-
haloacetic
-
brominate
-
halogen
-
haloacetonitriles
-
chloramination
- bromide
-
genotoxicity
- chloroform
-
effluent
-
wastewater
-
iodin
- ozone
-
swimming
-
humic
-
unregulated
-
trichloronitromethane
- n-nitrosodimethylamine
-
carbonaceous
- chloral
-
speciation
-
dichloroacetic
-
dichloroacetonitrile
- monochloramine
- haloketones
-
bromodichloromethane
-
swimmers
-
fulvic
-
hypochlorite
-
non-regulated
-
micropollutants
- clo2
-
pilot-scale
-
n-nitrosamines
- naclo
-
excitation-emission
-
bromoacetic
- chlorite
-
ballast
-
shower
-
acid-like
- pipe
-
potable
-
suwannee
- drug development
- synthesis
-
nanofiltration
-
biofiltration
- bromoform
-
indoor
- iodate
Reaction
Synonyms
3,4-dihydroxy 2-butanone-4-phosphate synthase, 3,4-dihydroxy-2-butanone 4-phosphate synthase, 3,4-dihydroxy-2-butanone-4-phosphate synthase, AtRIBA1, AtRIBA2, bifunctional GCHYII/DHBP, bifunctional GTP cyclohydrolase II/3,4-dihydroxy-2-butanone 4-phosphate synthase, DBPS, DHBP synthase, DHBPS, DHBPS/GCHII, dihydroxybutanone phosphate synthase, L-3,4-dihydroxy-2-butanone 4-phosphate synthase, L-3,4-dihydroxy-2-butanone-4-phosphate synthase, LcRIBA, More, Mtb-DHBPS, Mtb-ribA2, NbRibA, Rib3, ribA, ribA2, ribB, Sp0176, vDHBPS, vribB
ECTree
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Metals Ions
Metals Ions on EC 4.1.99.12 - 3,4-dihydroxy-2-butanone-4-phosphate synthase
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Ca2+
Fe3+
the enzyme shows activity in the presence of the trivalent metal ion, Fe3+
Mg2+
Mn2+
Ni2+
Zn2+
additional information
Ca2+
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Ca2+ binding requires the binding of the substrate, binding involves Glu204, Glu97, and Asn207
Mg2+
essential for catalytic activity and in stabilization of the substrate
Mg2+
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required, two Mg2+ cations that bind to the oxygen substituents of the C2, C3, C4, and phosphate groups of the substrate, the side chains of Glu37 and His153, and water molecules
Mg2+
required, best physiological metal activator, the divalent metal ion, Mg2+ plays a crucial role for acid/base catalysis
Zn2+
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bound at His164, binding involves His206, Glu132, and Glu128
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substrate binding structure involving a dimetal center, overview
additional information
the enzyme depends on divalent metal ions, a dimetal center is involved in substrate binding
additional information
the GTP cyclohydrolase II subunit has also bound Zn2+ ions
additional information
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the GTP cyclohydrolase II subunit has also bound Zn2+ ions
additional information
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the position of the metal cofactors and the substrates phosphate group are further stabilized by an extensive hydrogen-bond and salt-bridge network, overview