4.1.99.12: 3,4-dihydroxy-2-butanone-4-phosphate synthase
This is an abbreviated version!
For detailed information about 3,4-dihydroxy-2-butanone-4-phosphate synthase, go to the full flat file.
Word Map on EC 4.1.99.12
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4.1.99.12
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disinfection
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trihalomethanes
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haloacetic
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brominate
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halogen
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haloacetonitriles
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chloramination
-
bromide
-
genotoxicity
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chloroform
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effluent
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wastewater
-
iodin
-
ozone
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swimming
-
humic
-
unregulated
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trichloronitromethane
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n-nitrosodimethylamine
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carbonaceous
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chloral
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speciation
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dichloroacetic
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dichloroacetonitrile
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monochloramine
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haloketones
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bromodichloromethane
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swimmers
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fulvic
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hypochlorite
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non-regulated
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micropollutants
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clo2
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pilot-scale
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n-nitrosamines
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naclo
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excitation-emission
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bromoacetic
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chlorite
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ballast
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shower
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acid-like
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pipe
-
potable
-
suwannee
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drug development
-
synthesis
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nanofiltration
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biofiltration
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bromoform
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indoor
-
iodate
- 4.1.99.12
-
disinfection
-
trihalomethanes
-
haloacetic
-
brominate
-
halogen
-
haloacetonitriles
-
chloramination
- bromide
-
genotoxicity
- chloroform
-
effluent
-
wastewater
-
iodin
- ozone
-
swimming
-
humic
-
unregulated
-
trichloronitromethane
- n-nitrosodimethylamine
-
carbonaceous
- chloral
-
speciation
-
dichloroacetic
-
dichloroacetonitrile
- monochloramine
- haloketones
-
bromodichloromethane
-
swimmers
-
fulvic
-
hypochlorite
-
non-regulated
-
micropollutants
- clo2
-
pilot-scale
-
n-nitrosamines
- naclo
-
excitation-emission
-
bromoacetic
- chlorite
-
ballast
-
shower
-
acid-like
- pipe
-
potable
-
suwannee
- drug development
- synthesis
-
nanofiltration
-
biofiltration
- bromoform
-
indoor
- iodate
Reaction
Synonyms
3,4-dihydroxy 2-butanone-4-phosphate synthase, 3,4-dihydroxy-2-butanone 4-phosphate synthase, 3,4-dihydroxy-2-butanone-4-phosphate synthase, AtRIBA1, AtRIBA2, bifunctional GCHYII/DHBP, bifunctional GTP cyclohydrolase II/3,4-dihydroxy-2-butanone 4-phosphate synthase, DBPS, DHBP synthase, DHBPS, DHBPS/GCHII, dihydroxybutanone phosphate synthase, L-3,4-dihydroxy-2-butanone 4-phosphate synthase, L-3,4-dihydroxy-2-butanone-4-phosphate synthase, LcRIBA, More, Mtb-DHBPS, Mtb-ribA2, NbRibA, Rib3, ribA, ribA2, ribB, Sp0176, vDHBPS, vribB
ECTree
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Substrates Products
Substrates Products on EC 4.1.99.12 - 3,4-dihydroxy-2-butanone-4-phosphate synthase
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REACTION DIAGRAM
formate + L-3,4-dihydroxy-2-butanone-4-phosphate
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?
D-ribulose 5-phosphate
formate + L-3,4-dihydroxy-2-butanone-4-phosphate
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rate-limiting step in riboflavin biosynthesis
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-
?
D-ribulose 5-phosphate
formate + L-3,4-dihydroxy-2-butanone-4-phosphate
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-
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?
D-ribulose 5-phosphate
formate + L-3,4-dihydroxy-2-butanone-4-phosphate
the enzyme is involved in riboflavin biosynthesis
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-
?
D-ribulose 5-phosphate
formate + L-3,4-dihydroxy-2-butanone-4-phosphate
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-
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?
D-ribulose 5-phosphate
formate + L-3,4-dihydroxy-2-butanone-4-phosphate
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-
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?
D-ribulose 5-phosphate
formate + L-3,4-dihydroxy-2-butanone-4-phosphate
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-
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?
D-ribulose 5-phosphate
formate + L-3,4-dihydroxy-2-butanone-4-phosphate
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step in biosynthesis of vitamin B2, riboflavin
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-
?
D-ribulose 5-phosphate
formate + L-3,4-dihydroxy-2-butanone-4-phosphate
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the enzyme is important in riboflavin biosynthesis, overview
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-
?
D-ribulose 5-phosphate
formate + L-3,4-dihydroxy-2-butanone-4-phosphate
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the enzyme is involved in the pathway of riboflavin biosynthesis
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-
?
D-ribulose 5-phosphate
formate + L-3,4-dihydroxy-2-butanone-4-phosphate
the enzyme is involved in the pathway of riboflavin biosynthesis
-
-
?
D-ribulose 5-phosphate
formate + L-3,4-dihydroxy-2-butanone-4-phosphate
the enzyme is involved in the pathway of riboflavin biosynthesis, overview
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-
?
D-ribulose 5-phosphate
formate + L-3,4-dihydroxy-2-butanone-4-phosphate
substrate preparation, overview
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?
D-ribulose 5-phosphate
formate + L-3,4-dihydroxy-2-butanone-4-phosphate
the enzyme is important in the riboflavin biosynthesis, the riboflavin precursor, 6,7-dimethyl-8-ribityllumazine, is formed by condensation of 5-amino-6-ribitylamino-2,4(1H,3H)-pyrimidinedione (1) with 3,4-dihydroxy-2-butanone 4-phosphate, overview
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?
D-ribulose 5-phosphate
formate + L-3,4-dihydroxy-2-butanone-4-phosphate
Escherichia coli W3110 / ATCC 27325
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?
D-ribulose 5-phosphate
formate + L-3,4-dihydroxy-2-butanone-4-phosphate
Escherichia coli W3110 / ATCC 27325
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step in biosynthesis of vitamin B2, riboflavin
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?
D-ribulose 5-phosphate
formate + L-3,4-dihydroxy-2-butanone-4-phosphate
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-
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?
D-ribulose 5-phosphate
formate + L-3,4-dihydroxy-2-butanone-4-phosphate
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DHBPS supplies the building blocks for the assembly of the xylene ring of the vitamin B2, riboflavin, all eight C atoms of the xylene moiety are derived from the product of the enzyme
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?
D-ribulose 5-phosphate
formate + L-3,4-dihydroxy-2-butanone-4-phosphate
step in the biosynthesis of riboflavin, vitamin B2, ribulose 5-phosphate is converted into 3,4-dihydroxy-2-butanone 4-phosphate while its C4 atom is released as formate in a sequence of metal-dependent reactions
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?
D-ribulose 5-phosphate
formate + L-3,4-dihydroxy-2-butanone-4-phosphate
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the enzyme is involved in the pathway of riboflavin biosynthesis
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-
?
D-ribulose 5-phosphate
formate + L-3,4-dihydroxy-2-butanone-4-phosphate
a dimetal center is involved in substrate binding, structure-function relationship, overview
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?
D-ribulose 5-phosphate
formate + L-3,4-dihydroxy-2-butanone-4-phosphate
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substrate binding structure involving a dimetal center, overview
the enzyme converts ribulose 5-phosphate into 3,4-dihydroxy-2-butanone 4-phosphate, while its C4 atom is released as formate
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?
D-ribulose 5-phosphate
formate + L-3,4-dihydroxy-2-butanone-4-phosphate
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the reaction involves an intramolecular skeletal rearrangement, NMR study
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?
D-ribulose 5-phosphate
formate + L-3,4-dihydroxy-2-butanone-4-phosphate
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product identification by NMR and CD spectroscopy
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?
D-ribulose 5-phosphate
formate + L-3,4-dihydroxy-2-butanone-4-phosphate
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a step in the formation of the riboflavin precursor, 6,7-dimethyl-8-ribityllumazine, from 5-amino-6-ribitylamino-2,4(1H,3H)-pyrimidinedione requiring a phosphorylated 4-carbon intermediate, designated as compound X
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?
D-ribulose 5-phosphate
formate + L-3,4-dihydroxy-2-butanone-4-phosphate
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a step in the formation of the riboflavin precursor, 6,7-dimethyl-8-ribityllumazine, from 5-amino-6-ribitylamino-2,4(1H,3H)-pyrimidinedione requiring a phosphorylated 4-carbon intermediate, designated as compound X, analysis of the riboflavin biosynthetic pathway, overview
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?
D-ribulose 5-phosphate
formate + L-3,4-dihydroxy-2-butanone-4-phosphate
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carbon atoms 1-3 of the enzyme product correspond to carbon atoms 1-3 of the substrate, whereas C-4 of the product stems from C-6 of the substrate. Carbon atom 4 of the substrate is released as formate together with the hydrogen atom attached to it. The skeletal rearrangement which leads to the loss of C-4 and the direct linkage between C-3 and C-6 of the substrate is an intramolecular reaction, the hydrogen atom at C-3 of the enzyme product is introduced from solvent water
product identification by GC-MS
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?
D-ribulose 5-phosphate
formate + L-3,4-dihydroxy-2-butanone-4-phosphate
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-
-
-
?
D-ribulose 5-phosphate
formate + L-3,4-dihydroxy-2-butanone-4-phosphate
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-
-
-
?
D-ribulose 5-phosphate
formate + L-3,4-dihydroxy-2-butanone-4-phosphate
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-
-
-
?
D-ribulose 5-phosphate
formate + L-3,4-dihydroxy-2-butanone-4-phosphate
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-
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?
formate + L-3,4-dihydroxybutan-2-one 4-phosphate
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?
D-ribulose 5-phosphate
formate + L-3,4-dihydroxybutan-2-one 4-phosphate
isozyme AtRIBA1
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?
D-ribulose 5-phosphate
formate + L-3,4-dihydroxybutan-2-one 4-phosphate
isozyme AtRIBA2
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?
D-ribulose 5-phosphate
formate + L-3,4-dihydroxybutan-2-one 4-phosphate
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-
-
?
D-ribulose 5-phosphate
formate + L-3,4-dihydroxybutan-2-one 4-phosphate
isozyme AtRIBA1
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-
?
D-ribulose 5-phosphate
formate + L-3,4-dihydroxybutan-2-one 4-phosphate
isozyme AtRIBA2
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?
D-ribulose 5-phosphate
formate + L-3,4-dihydroxybutan-2-one 4-phosphate
-
-
-
?
D-ribulose 5-phosphate
formate + L-3,4-dihydroxybutan-2-one 4-phosphate
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-
-
?
D-ribulose 5-phosphate
formate + L-3,4-dihydroxybutan-2-one 4-phosphate
Escherichia coli K-12 / MG1655
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-
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?
D-ribulose 5-phosphate
formate + L-3,4-dihydroxybutan-2-one 4-phosphate
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-
-
-
?
D-ribulose 5-phosphate
formate + L-3,4-dihydroxybutan-2-one 4-phosphate
-
-
-
?
D-ribulose 5-phosphate
formate + L-3,4-dihydroxybutan-2-one 4-phosphate
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-
-
?
D-ribulose 5-phosphate
formate + L-3,4-dihydroxybutan-2-one 4-phosphate
Mycobacterium tuberculosis H37Ra / ATCC 25177
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?
D-ribulose 5-phosphate
formate + L-3,4-dihydroxybutan-2-one 4-phosphate
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-
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?
D-ribulose 5-phosphate
formate + L-3,4-dihydroxybutan-2-one 4-phosphate
-
-
-
?
D-ribulose 5-phosphate
formate + L-3,4-dihydroxybutan-2-one 4-phosphate
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-
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?
D-ribulose 5-phosphate
formate + L-3,4-dihydroxybutan-2-one 4-phosphate
Vibrio cholerae serotype O1 ATCC 39315 / El Tor Inaba N16961
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RibA is the rate limiting enzyme in an industrial riboflavin producing strain
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additional information
?
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RibA is a bifunctional enzyme possessing 3,4-dihydroxy-2-butanone 4-phosphate synthase activity located in the N-terminal half of the protein and GTP cyclohydrolase II activity, EC 3.5.4.25, of the C-terminal domain, overview
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additional information
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the position of the metal cofactors and the substrates phosphate group are further stabilized by an extensive hydrogen-bond and salt-bridge network, overview
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additional information
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the enzyme is involved in the riboflavin biosynthetic pathway, but has a second unrelated function in expression of mitochondrial respiration
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additional information
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substrate binding structures, overview
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