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4.1.2.47: (S)-hydroxynitrile lyase

This is an abbreviated version!
For detailed information about (S)-hydroxynitrile lyase, go to the full flat file.

Word Map on EC 4.1.2.47

Reaction

an aliphatic (S)-hydroxynitrile
=
cyanide
+
an aliphatic aldehyde or ketone

Synonyms

(R)-LuHNL, (R)-Oxynitrilase, (S)-cyanohydrin producing hydroxynitrile lyase, (S)-Hb-HNL, (S)-HbHNL, (S)-HNL, (S)-Hydroxynitrile lyase, (S)-Me-HNL, (S)-MeHNL, (S)-Oxynitrilase, (S)-selective HNL, (S)-selective hydroxynitrile lyase, Acetone cyanohydrin lyase, ACL, alpha-Hydroxynitrile lyase, EC 4.1.2.37, EC 4.1.2.39, Hb-HNL, HbHNL, HNL, HNL1, Hydroxynitrile lyase, LuHNL, MeHNKL, MeHNL, mut-HNL1, Oxynitrilase, S-HnL, S-hydroxynitrile lyase, S-selective HnL, S-selective hydroxynitrile lyase, S-stereoselective HNL

ECTree

     4 Lyases
         4.1 Carbon-carbon lyases
             4.1.2 Aldehyde-lyases
                4.1.2.47 (S)-hydroxynitrile lyase

Inhibitors

Inhibitors on EC 4.1.2.47 - (S)-hydroxynitrile lyase

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INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
1-butyl-3-methylimidazolium tetrahydroborate
-
2-6% v/v, inactivates
1-hexyl-3-methylimidazolium tetrahydroborate
-
2-6% v/v, inactivates
1-pentyl-3-methylimidazolium tetrahydroborate
-
2-6% v/v, inactivates
1-propyl-3-methylimidazolium tetrahydroborate
-
2-6% v/v, inactivates
2-methyl-2-butanol
-
-
2-Methylbutyraldehyde
-
-
4-(2-aminoethyl)-benzenesulfonyl fluoride hydrochloride
-
acetaldehyde
-
-
acetate
acetone
Ag+
1 mM, 12% residual activity
benzaldehyde
butanol
-
-
Chlorobutanol
-
-
diethyl dicarbonate
3 MM, 93% inhibition
diisopropyl fluorophosphate
ethanol
-
-
formaldehyde
-
-
HCN
shows S-linear I-parabolic mixed-type inhibition
hexafluoroacetone
-
-
isobutanol
-
-
Isobutyraldehyde
-
-
mandelonitrile
-
-
methanol
-
-
methyl ethyl ketone
Octanol
-
-
p-chloromercurybenzoate
-
Pentanol
-
-
phenol
Phenylmethyl sulfonylfluoride
1 mM, 27% residual activity
phenylmethylsulfonyl fluoride
-
Propanol
-
-
propionaldehyde
-
-
rhodanide
-
very strong competitive inhibitor
thiocyanate
trichloracetaldehyde
-
-
additional information
-