4.1.2.25: dihydroneopterin aldolase

This is an abbreviated version!
For detailed information about dihydroneopterin aldolase, go to the full flat file.

Reaction

Synonyms

aldolase, dihydroneopterin, At3g11750, At5g62980, DHNA, DHNA-HPPK, dihydroneopterin aldolase, dihydroneopterin aldolase/epimerase, FASA, folA, FolB, FolB1, FolB2, MptD, Rv3607c

ECTree

     4 Lyases

         4.1 Carbon-carbon lyases

             4.1.2 Aldehyde-lyases

                4.1.2.25 dihydroneopterin aldolase

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Results	in table
2	Activating Compound
26755	AA Sequence
2	Application
1	CAS Registry Number
17	Cloned(Commentary)
6	Crystallization (Commentary)
1	Expression
3	General Information
16	IC50 Value
28	Inhibitors
9	kcat/KM [mM/s]
35	KM Value [mM]
2	Metals/Ions
23	Molecular Weight [Da]
23	Natural Substrates/ Products (Substrates)
249	Organism
8	Pathway
42	PDB ID
5	pH Optimum
1	pH Stability
29	Protein Variants
18	Purification (Commentary)
5	Reaction
1	Reaction Type
44	Reference
2	Source Tissue
3	Specific Activity [micromol/min/mg]
78	Substrates and Products (Substrate)
27	Subunits
44	Synonyms
1	Systematic Name
2	Temperature Stability [°C]
25	Turnover Number [1/s]

IC50 Value

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IC50 Value on EC 4.1.2.25 - dihydroneopterin aldolase

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IC50 VALUE [mM]

INHIBITOR

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

IMAGE

0.00074

3-(5-amino-7-hydroxy-[1,2,3]triazolo[4,5-d]pyrimidin-2-yl)-N-(1-hydroxycyclohexylmethyl)benzamide

Staphylococcus aureus

-

IC50: 0.00074 mM

665970

0.00095

3-(5-amino-7-hydroxy-[1,2,3]triazolo[4,5-d]pyrimidin-2-yl)-N-(2,2-bis-hydroxymethylbutyl)benzamide

Staphylococcus aureus

-

IC50: 0.00095 mM

665970

0.00055

3-(5-amino-7-hydroxy-[1,2,3]triazolo[4,5-d]pyrimidin-2-yl)-N-(2,3-dihydrobenzofuran-5-ylmethyl)benzamide

Staphylococcus aureus

-

IC50: 0.00055 mM

665970

0.001

3-(5-amino-7-hydroxy-[1,2,3]triazolo[4,5-d]pyrimidin-2-yl)-N-(3,5-bistrifluoromethylbenzyl)benzamide

Staphylococcus aureus

-

IC50: 0.001 mM

665970

0.000068

3-(5-amino-7-hydroxy-[1,2,3]triazolo[4,5-d]pyrimidin-2-yl)-N-(3,5-dichlorobenzyl)benzamid

Staphylococcus aureus

-

IC50: 0.000068 mM

665970

0.00073

3-(5-amino-7-hydroxy-[1,2,3]triazolo[4,5-d]pyrimidin-2-yl)-N-(3-hydroxy-2,2-dimethylpropyl)benzamide

Staphylococcus aureus

-

IC50: 0.00073 mM

665970

0.0023

3-(5-amino-7-hydroxy-[1,2,3]triazolo[4,5-d]pyrimidin-2-yl)-N-(3-hydroxypropyl)benzamide

Staphylococcus aureus

-

IC50: 0.0023 mM

665970

0.002

3-(5-amino-7-hydroxy-[1,2,3]triazolo[4,5-d]pyrimidin-2-yl)-N-(4-hydroxybutyl)benzamide

Staphylococcus aureus

-

IC50: 0.002 mM

665970

0.022

3-(5-amino-7-hydroxy-[1,2,3]triazolo[4,5-d]pyrimidin-2-yl)-N-(4-phenoxybenzyl)benzamide

Staphylococcus aureus

-

IC50: 0.022 mM

665970

0.00031

3-(5-amino-7-hydroxy-[1,2,3]triazolo[4,5-d]pyrimidin-2-yl)-N-benzo[1,3]dioxol-5-ylmethylbenzamide

Staphylococcus aureus

-

IC50: 0.00031 mM

665970

0.025

3-(5-amino-7-hydroxy-[1,2,3]triazolo[4,5-d]pyrimidin-2-yl)-N-biphenyl-4-ylmethylbenzamide

Staphylococcus aureus

-

IC50: 0.025 mM

665970

0.00035

3-(5-amino-7-hydroxy-[1,2,3]triazolo[4,5-d]pyrimidin-2-yl)-N-cis-(2-hydroxycycloheptylmethyl)benzamide

Staphylococcus aureus

-

IC50: 0.00035 mM

665970

0.00041

3-(5-amino-7-hydroxy-[1,2,3]triazolo[4,5-d]pyrimidin-2-yl)-N-cis-(2-hydroxycyclohexylmethyl)benzamide

Staphylococcus aureus

-

IC50: 0.00041 mM

665970

0.00032

3-(5-amino-7-hydroxy-[1,2,3]triazolo[4,5-d]pyrimidin-2-yl)-N-trans-(2-hydroxycyclohexylmethyl)benzamide

Staphylococcus aureus

-

IC50: 0.00032 mM

665970

0.00003

3-(5-amino-7-hydroxy-[1,2,3]triazolo[4,5-d]pyrimidin-2-yl)-N-[2-(2-hydroxymethylphenylsulfanyl)benzyl]-benzamide

Staphylococcus aureus

-

IC50: 0.00003 mM

665970

0.0015

3-(5-amino-7-hydroxy-[1,2,3]triazolo[4,5-d]pyrimidin-2-yl)benzoic acid

Staphylococcus aureus

-

IC50: 0.0015 mM

665970