4.1.2.25: dihydroneopterin aldolase

This is an abbreviated version!
For detailed information about dihydroneopterin aldolase, go to the full flat file.

Reaction

Synonyms

aldolase, dihydroneopterin, At3g11750, At5g62980, DHNA, DHNA-HPPK, dihydroneopterin aldolase, dihydroneopterin aldolase/epimerase, FASA, folA, FolB, FolB1, FolB2, MptD, Rv3607c

ECTree

     4 Lyases

         4.1 Carbon-carbon lyases

             4.1.2 Aldehyde-lyases

                4.1.2.25 dihydroneopterin aldolase

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Results	in table
2	Activating Compound
26755	AA Sequence
2	Application
1	CAS Registry Number
17	Cloned(Commentary)
6	Crystallization (Commentary)
1	Expression
3	General Information
16	IC50 Value
28	Inhibitors
9	kcat/KM [mM/s]
35	KM Value [mM]
2	Metals/Ions
23	Molecular Weight [Da]
23	Natural Substrates/ Products (Substrates)
249	Organism
8	Pathway
42	PDB ID
5	pH Optimum
1	pH Stability
29	Protein Variants
18	Purification (Commentary)
5	Reaction
1	Reaction Type
44	Reference
2	Source Tissue
3	Specific Activity [micromol/min/mg]
78	Substrates and Products (Substrate)
27	Subunits
44	Synonyms
1	Systematic Name
2	Temperature Stability [°C]
25	Turnover Number [1/s]

Natural Substrates Products

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Natural Substrates Products on EC 4.1.2.25 - dihydroneopterin aldolase

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NATURAL SUBSTRATE

NATURAL PRODUCT

REACTION DIAGRAM

ORGANISM

UNIPROT

COMMENTARY
(Substrate)

LITERATURE
(Substrate)

COMMENTARY
(Product)

LITERATURE
(Product)

REVERSIBILITY
r=reversible
ir=irreversible
?=not specified

2-Amino-4-hydroxy-6-(D-erythro-1,2,3-trihydroxypropyl)-7,8-dihydropteridine

?

5 entries

6-hydroxymethyl-7,8-dihydropterin + glycolaldehyde

7,8-dihydroneopterin + 7,8-dihydromonapterin

5 entries

7,8-dihydroneopterin

6-(hydroxymethyl)-7,8-dihydropterin + glycolaldehyde

6 entries

7,8-dihydroneopterin

6-hydroxymethyl-7,8-dihydropterin + glycolaldehyde

3 entries

additional information

?

-

Escherichia coli

-

enzyme in folate biosynthesis

652042

-

652042

?

2-Amino-4-hydroxy-6-(D-erythro-1,2,3-trihydroxypropyl)-7,8-dihydropteridine

?

Escherichia coli

-

enzyme is involved in the biosynthetic pathway of tetrahydrofolate

5109

-

-

?

2-Amino-4-hydroxy-6-(D-erythro-1,2,3-trihydroxypropyl)-7,8-dihydropteridine

?

Escherichia coli XL1-Blue

-

enzyme is involved in the biosynthetic pathway of tetrahydrofolate

5109

-

-

?

2-Amino-4-hydroxy-6-(D-erythro-1,2,3-trihydroxypropyl)-7,8-dihydropteridine

?

Pneumocystis carinii

-

first enzyme in the folate synthesis pathway

5105, 5108

-

-

?

2-Amino-4-hydroxy-6-(D-erythro-1,2,3-trihydroxypropyl)-7,8-dihydropteridine

?

Staphylococcus aureus

-

the enzyme is involved in the de novo synthesis of folic acid from guanosine triphosphate

5110

-

-

?

2-Amino-4-hydroxy-6-(D-erythro-1,2,3-trihydroxypropyl)-7,8-dihydropteridine

?

Streptococcus pneumoniae

-

first enzyme in the folate synthesis pathway

5107

-

-

?

6-hydroxymethyl-7,8-dihydropterin + glycolaldehyde

7,8-dihydroneopterin + 7,8-dihydromonapterin

Escherichia coli

P0AC16

-

747481

-

-

r

6-hydroxymethyl-7,8-dihydropterin + glycolaldehyde

7,8-dihydroneopterin + 7,8-dihydromonapterin

Methanocaldococcus jannaschii

-

-

748090

-

-

r

6-hydroxymethyl-7,8-dihydropterin + glycolaldehyde

7,8-dihydroneopterin + 7,8-dihydromonapterin

Methanocaldococcus jannaschii MJ0408

-

-

748090

-

-

r

6-hydroxymethyl-7,8-dihydropterin + glycolaldehyde

7,8-dihydroneopterin + 7,8-dihydromonapterin

Mycobacterium tuberculosis

P9WNG5

-

746987

-

-

r

6-hydroxymethyl-7,8-dihydropterin + glycolaldehyde

7,8-dihydroneopterin + 7,8-dihydromonapterin

Mycobacterium tuberculosis H37Rv

P9WNG5

-

746987

-

-

r

7,8-dihydroneopterin

6-(hydroxymethyl)-7,8-dihydropterin + glycolaldehyde

Escherichia coli

P0AC16

-

747221, 748117

-

-

?

7,8-dihydroneopterin

6-(hydroxymethyl)-7,8-dihydropterin + glycolaldehyde

Escherichia coli

P0AC16

-

747481

-

-

r

7,8-dihydroneopterin

6-(hydroxymethyl)-7,8-dihydropterin + glycolaldehyde

Methanocaldococcus jannaschii

-

-

748090

-

-

r

7,8-dihydroneopterin

6-(hydroxymethyl)-7,8-dihydropterin + glycolaldehyde

Methanocaldococcus jannaschii MJ0408

-

-

748090

-

-

r

7,8-dihydroneopterin

6-(hydroxymethyl)-7,8-dihydropterin + glycolaldehyde

Mycobacterium tuberculosis

P9WNG5

-

746987

-

-

r

7,8-dihydroneopterin

6-(hydroxymethyl)-7,8-dihydropterin + glycolaldehyde

Mycobacterium tuberculosis H37Rv

P9WNG5

-

746987

-

-

r

7,8-dihydroneopterin

6-hydroxymethyl-7,8-dihydropterin + glycolaldehyde

Escherichia coli

-

-

682008, 704296

-

-

?

7,8-dihydroneopterin

6-hydroxymethyl-7,8-dihydropterin + glycolaldehyde

Escherichia coli MG1655

-

-

704296

-

-

?

7,8-dihydroneopterin

6-hydroxymethyl-7,8-dihydropterin + glycolaldehyde

Plasmodium falciparum

-

-

695231

-

-

?