4.1.2.25: dihydroneopterin aldolase

This is an abbreviated version!
For detailed information about dihydroneopterin aldolase, go to the full flat file.

Reaction

Synonyms

aldolase, dihydroneopterin, At3g11750, At5g62980, DHNA, DHNA-HPPK, dihydroneopterin aldolase, dihydroneopterin aldolase/epimerase, FASA, folA, FolB, FolB1, FolB2, MptD, Rv3607c

ECTree

     4 Lyases

         4.1 Carbon-carbon lyases

             4.1.2 Aldehyde-lyases

                4.1.2.25 dihydroneopterin aldolase

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Results	in table
2	Activating Compound
26755	AA Sequence
2	Application
1	CAS Registry Number
17	Cloned(Commentary)
6	Crystallization (Commentary)
1	Expression
3	General Information
16	IC50 Value
28	Inhibitors
9	kcat/KM [mM/s]
35	KM Value [mM]
2	Metals/Ions
23	Molecular Weight [Da]
23	Natural Substrates/ Products (Substrates)
249	Organism
8	Pathway
42	PDB ID
5	pH Optimum
1	pH Stability
29	Protein Variants
18	Purification (Commentary)
5	Reaction
1	Reaction Type
44	Reference
2	Source Tissue
3	Specific Activity [micromol/min/mg]
78	Substrates and Products (Substrate)
27	Subunits
44	Synonyms
1	Systematic Name
2	Temperature Stability [°C]
25	Turnover Number [1/s]

KM Value

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KM Value on EC 4.1.2.25 - dihydroneopterin aldolase

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KM VALUE [mM]

SUBSTRATE

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

IMAGE

0.0023 - 0.064

2-amino-4-hydroxy-6-(D-erythro-1,2,3-trihydroxypropyl)-7,8-dihydropteridine

6 entries

0.00076 - 9.8

7,8-dihydro-L-monapterin

7 entries

0.00017 - 0.057

7,8-dihydromonapterin

5 entries

0.00016 - 9.7

7,8-dihydroneopterin

15 entries

10

glycoaldehyde

Staphylococcus aureus

-

apparent value

679768

0.0023

2-amino-4-hydroxy-6-(D-erythro-1,2,3-trihydroxypropyl)-7,8-dihydropteridine

Pneumocystis carinii

-

-

5105

0.009

2-amino-4-hydroxy-6-(D-erythro-1,2,3-trihydroxypropyl)-7,8-dihydropteridine

Escherichia coli

-

-

5103, 5104

0.021

2-amino-4-hydroxy-6-(D-erythro-1,2,3-trihydroxypropyl)-7,8-dihydropteridine

Haemophilus influenzae

-

cleavage

5109

0.043

2-amino-4-hydroxy-6-(D-erythro-1,2,3-trihydroxypropyl)-7,8-dihydropteridine

Haemophilus influenzae

-

epimerization

5109

0.045

2-amino-4-hydroxy-6-(D-erythro-1,2,3-trihydroxypropyl)-7,8-dihydropteridine

Escherichia coli

-

epimerization

5109

0.064

2-amino-4-hydroxy-6-(D-erythro-1,2,3-trihydroxypropyl)-7,8-dihydropteridine

Escherichia coli

-

cleavage

5109

0.00076

7,8-dihydro-L-monapterin

Escherichia coli

-

mutant enzyme E21A, in 100 mM Tris-HCl, 1 mM EDTA, and 5 mM dithiothreitol (pH 8.3)

678176

0.0029

7,8-dihydro-L-monapterin

Escherichia coli

-

mutant enzyme K98A, in 100 mM Tris-HCl, 1 mM EDTA, and 5 mM dithiothreitol (pH 8.3)

678176

0.004

7,8-dihydro-L-monapterin

Staphylococcus aureus

-

mutant enzyme E22A, in 100 mM Tris-HCl, 1 mM EDTA, and 5 mM dithiothreitol (pH 8.3)

678176

0.0055

7,8-dihydro-L-monapterin

Staphylococcus aureus

-

wild type enzyme, in 100 mM Tris-HCl, 1 mM EDTA, and 5 mM dithiothreitol (pH 8.3)

678176

0.0095

7,8-dihydro-L-monapterin

Staphylococcus aureus

-

mutant enzyme K100A, in 100 mM Tris-HCl, 1 mM EDTA, and 5 mM dithiothreitol (pH 8.3)

678176

8

7,8-dihydro-L-monapterin

Escherichia coli

-

wild type enzyme, in 100 mM Tris-HCl, 1 mM EDTA, and 5 mM dithiothreitol (pH 8.3)

678176

9.8

7,8-dihydro-L-monapterin

Escherichia coli

-

mutant enzyme E73A, in 100 mM Tris-HCl, 1 mM EDTA, and 5 mM dithiothreitol (pH 8.3)

678176

0.00017

7,8-dihydromonapterin

Mycobacterium tuberculosis

P9WNC5

pH 7.0, 22°C

727676

0.016

7,8-dihydromonapterin

Haemophilus influenzae

-

cleavage

5109

0.019

7,8-dihydromonapterin

Haemophilus influenzae

-

epimerization

5109

0.036

7,8-dihydromonapterin

Escherichia coli

-

cleavage

5109

0.057

7,8-dihydromonapterin

Escherichia coli

-

epimerization

5109

0.00016

7,8-dihydroneopterin

Mycobacterium tuberculosis

P9WNC5

pH 7.0, 22°C

727676

0.0016

7,8-dihydroneopterin

Escherichia coli

-

mutant enzyme E21A, in 100 mM Tris-HCl, 1 mM EDTA, and 5 mM dithiothreitol (pH 8.3)

678176

0.0024

7,8-dihydroneopterin

Escherichia coli

-

mutant enzyme K98A, in 100 mM Tris-HCl, 1 mM EDTA, and 5 mM dithiothreitol (pH 8.3)

678176

0.0039

7,8-dihydroneopterin

Staphylococcus aureus

-

mutant enzyme E22A, in 100 mM Tris-HCl, 1 mM EDTA, and 5 mM dithiothreitol (pH 8.3)

678176

0.0046

7,8-dihydroneopterin

Staphylococcus aureus

-

wild type enzyme, in 100 mM Tris-HCl, 1 mM EDTA, and 5 mM dithiothreitol (pH 8.3)

678176

0.0058

7,8-dihydroneopterin

Staphylococcus aureus

-

mutant enzyme K100A, in 100 mM Tris-HCl, 1 mM EDTA, and 5 mM dithiothreitol (pH 8.3)

678176

0.0074

7,8-dihydroneopterin

Escherichia coli

-

wild type enzyme, in 100 mM Tris-HCl, 1 mM EDTA, and 5 mM dithiothreitol (pH 8.3)

678176

0.0084

7,8-dihydroneopterin

Methanocaldococcus jannaschii

-

mutant enzyme Q61A, at pH 7.6 and 70°C

748090

0.0099

7,8-dihydroneopterin

Methanocaldococcus jannaschii

-

wild type enzyme, at pH 7.6 and 70°C

748090

0.011

7,8-dihydroneopterin

Methanocaldococcus jannaschii

-

mutant enzyme Y111F, at pH 7.6 and 70°C

748090

0.021

7,8-dihydroneopterin

Methanocaldococcus jannaschii

-

mutant enzyme H35N, at pH 7.6 and 70°C

748090

0.03

7,8-dihydroneopterin

Methanocaldococcus jannaschii

-

mutant enzyme Y78F, at pH 7.6 and 70°C

748090

0.0645

7,8-dihydroneopterin

Methanocaldococcus jannaschii

-

wild type enzyme, at pH 7.6 and 25°C

748090

0.25

7,8-dihydroneopterin

Methanocaldococcus jannaschii

-

Km above 0.25 mM, mutant enzyme E25Q, at pH 7.6 and 70°C

748090

9.7

7,8-dihydroneopterin

Escherichia coli

-

mutant enzyme E73A, in 100 mM Tris-HCl, 1 mM EDTA, and 5 mM dithiothreitol (pH 8.3)

678176