4.1.2.25: dihydroneopterin aldolase

This is an abbreviated version!
For detailed information about dihydroneopterin aldolase, go to the full flat file.

Word Map on EC 4.1.2.25

4.1.2.25

folate

dhnas

6-hydroxymethyl-7,8-dihydropterin

folic

pyrophosphokinase

dihydropteroate

pteridine

cyclohydrolase

tetrahydrofolate

pneumocystis

hydroxymethyldihydropterin

epimerization

tetrahydrobiopterin

carinii

aldolases

octamer

antifolate

medicine

pharmacology

Reaction

Synonyms

aldolase, dihydroneopterin, At3g11750, At5g62980, DHNA, DHNA-HPPK, dihydroneopterin aldolase, dihydroneopterin aldolase/epimerase, FASA, folA, FolB, FolB1, FolB2, MptD, Rv3607c

ECTree

4 Lyases

4.1 Carbon-carbon lyases

4.1.2 Aldehyde-lyases

4.1.2.25 dihydroneopterin aldolase

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Results	in table
2	Activating Compound
26755	AA Sequence
2	Application
1	CAS Registry Number
17	Cloned(Commentary)
6	Crystallization (Commentary)
1	Expression
3	General Information
16	IC50 Value
28	Inhibitors
9	kcat/KM [mM/s]
35	KM Value [mM]
2	Metals/Ions
23	Molecular Weight [Da]
23	Natural Substrates/ Products (Substrates)
249	Organism
8	Pathway
42	PDB ID
5	pH Optimum
1	pH Stability
29	Protein Variants
18	Purification (Commentary)
5	Reaction
1	Reaction Type
44	Reference
2	Source Tissue
3	Specific Activity [micromol/min/mg]
78	Substrates and Products (Substrate)
27	Subunits
44	Synonyms
1	Systematic Name
2	Temperature Stability [°C]
25	Turnover Number [1/s]

Organism

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Organism on EC 4.1.2.25 - dihydroneopterin aldolase

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Escherichia coli B / ATCC 11303

5104

Escherichia coli MG1655

704296

Haemophilus influenzae

5109

Methanocaldococcus jannaschii

748090

Methanocaldococcus jannaschii MJ0408

748090

Mycobacterium tuberculosis

2 entries

Mycobacterium tuberculosis H37Rv

746987

P9WNG5

SwissProt

no activity in mammalia

5108

no activity in Plasmodium falciparum

Plasmodium falciparum cell extracts have SHMT and PPPK-DHPS but not DHNA activities

682008

Plasmodium falciparum

695231

Pneumocystis carinii

multifunctional Fas enzyme with the activity of the first three enzymes of the folate synthesis pathway: dihydroneopterin aldolase, hydroxymethyldihydropterin pyrophosphokinase and dihydropteroate synthase

5105, 5106, 5108

Solanum lycopersicum

2 entries

Staphylococcus aureus

4 entries

Streptococcus pneumoniae

2 entries