4.1.2.25: dihydroneopterin aldolase

This is an abbreviated version!
For detailed information about dihydroneopterin aldolase, go to the full flat file.

Reaction

Synonyms

aldolase, dihydroneopterin, At3g11750, At5g62980, DHNA, DHNA-HPPK, dihydroneopterin aldolase, dihydroneopterin aldolase/epimerase, FASA, folA, FolB, FolB1, FolB2, MptD, Rv3607c

ECTree

     4 Lyases

         4.1 Carbon-carbon lyases

             4.1.2 Aldehyde-lyases

                4.1.2.25 dihydroneopterin aldolase

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Results	in table
2	Activating Compound
26755	AA Sequence
2	Application
1	CAS Registry Number
17	Cloned(Commentary)
6	Crystallization (Commentary)
1	Expression
3	General Information
16	IC50 Value
28	Inhibitors
9	kcat/KM [mM/s]
35	KM Value [mM]
2	Metals/Ions
23	Molecular Weight [Da]
23	Natural Substrates/ Products (Substrates)
249	Organism
8	Pathway
42	PDB ID
5	pH Optimum
1	pH Stability
29	Protein Variants
18	Purification (Commentary)
5	Reaction
1	Reaction Type
44	Reference
2	Source Tissue
3	Specific Activity [micromol/min/mg]
78	Substrates and Products (Substrate)
27	Subunits
44	Synonyms
1	Systematic Name
2	Temperature Stability [°C]
25	Turnover Number [1/s]

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Turnover Number on EC 4.1.2.25 - dihydroneopterin aldolase

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TURNOVER NUMBER [1/s]

SUBSTRATE

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

IMAGE

0.0000023 - 0.089

7,8-dihydro-L-monapterin

8 entries

0.006

7,8-dihydromonapterin

Mycobacterium tuberculosis

P9WNC5

pH 7.0, 22°C

727676

0.0000022 - 1

7,8-dihydroneopterin

16 entries

0.0000023

7,8-dihydro-L-monapterin

Escherichia coli

-

mutant enzyme E21A, in 100 mM Tris-HCl, 1 mM EDTA, and 5 mM dithiothreitol (pH 8.3)

678176

0.0000051

7,8-dihydro-L-monapterin

Staphylococcus aureus

-

mutant enzyme K100A, in 100 mM Tris-HCl, 1 mM EDTA, and 5 mM dithiothreitol (pH 8.3)

678176

0.0000053

7,8-dihydro-L-monapterin

Escherichia coli

-

mutant enzyme K98A, in 100 mM Tris-HCl, 1 mM EDTA, and 5 mM dithiothreitol (pH 8.3)

678176

0.0000057

7,8-dihydro-L-monapterin

Staphylococcus aureus

-

mutant enzyme K100Q, in 100 mM Tris-HCl, 1 mM EDTA, and 5 mM dithiothreitol (pH 8.3)

678176

0.000006

7,8-dihydro-L-monapterin

Escherichia coli

-

mutant enzyme E73A, in 100 mM Tris-HCl, 1 mM EDTA, and 5 mM dithiothreitol (pH 8.3)

678176

0.0000065

7,8-dihydro-L-monapterin

Staphylococcus aureus

-

mutant enzyme E22A, in 100 mM Tris-HCl, 1 mM EDTA, and 5 mM dithiothreitol (pH 8.3)

678176

0.01

7,8-dihydro-L-monapterin

Staphylococcus aureus

-

wild type enzyme, in 100 mM Tris-HCl, 1 mM EDTA, and 5 mM dithiothreitol (pH 8.3)

678176

0.089

7,8-dihydro-L-monapterin

Escherichia coli

-

wild type enzyme, in 100 mM Tris-HCl, 1 mM EDTA, and 5 mM dithiothreitol (pH 8.3)

678176

0.0000022

7,8-dihydroneopterin

Staphylococcus aureus

-

mutant enzyme K100A, in 100 mM Tris-HCl, 1 mM EDTA, and 5 mM dithiothreitol (pH 8.3)

678176

0.0000043

7,8-dihydroneopterin

Escherichia coli

-

mutant enzyme K98A, in 100 mM Tris-HCl, 1 mM EDTA, and 5 mM dithiothreitol (pH 8.3)

678176

0.0000065

7,8-dihydroneopterin

Escherichia coli

-

mutant enzyme E21A, in 100 mM Tris-HCl, 1 mM EDTA, and 5 mM dithiothreitol (pH 8.3)

678176

0.0000093

7,8-dihydroneopterin

Staphylococcus aureus

-

mutant enzyme E22A, in 100 mM Tris-HCl, 1 mM EDTA, and 5 mM dithiothreitol (pH 8.3)

678176

0.000016

7,8-dihydroneopterin

Staphylococcus aureus

-

mutant enzyme K100Q, in 100 mM Tris-HCl, 1 mM EDTA, and 5 mM dithiothreitol (pH 8.3)

678176

0.00073

7,8-dihydroneopterin

Escherichia coli

-

mutant enzyme E73A, in 100 mM Tris-HCl, 1 mM EDTA, and 5 mM dithiothreitol (pH 8.3)

678176

0.0054

7,8-dihydroneopterin

Mycobacterium tuberculosis

P9WNC5

pH 7.0, 22°C

727676

0.045

7,8-dihydroneopterin

Staphylococcus aureus

-

wild type enzyme, in 100 mM Tris-HCl, 1 mM EDTA, and 5 mM dithiothreitol (pH 8.3)

678176

0.048

7,8-dihydroneopterin

Methanocaldococcus jannaschii

-

mutant enzyme Q61A, at pH 7.6 and 70°C

748090

0.054

7,8-dihydroneopterin

Methanocaldococcus jannaschii

-

mutant enzyme Y78F, at pH 7.6 and 70°C

748090

0.055

7,8-dihydroneopterin

Methanocaldococcus jannaschii

-

mutant enzyme H35N, at pH 7.6 and 70°C

748090

0.07

7,8-dihydroneopterin

Methanocaldococcus jannaschii

-

wild type enzyme, at pH 7.6 and 25°C

748090

0.082

7,8-dihydroneopterin

Escherichia coli

-

wild type enzyme, in 100 mM Tris-HCl, 1 mM EDTA, and 5 mM dithiothreitol (pH 8.3)

678176

0.64

7,8-dihydroneopterin

Methanocaldococcus jannaschii

-

mutant enzyme Y111F, at pH 7.6 and 70°C

748090

0.68

7,8-dihydroneopterin

Methanocaldococcus jannaschii

-

mutant enzyme E25Q, at pH 7.6 and 70°C

748090

1

7,8-dihydroneopterin

Methanocaldococcus jannaschii

-

wild type enzyme, at pH 7.6 and 70°C

748090