4.1.2.25: dihydroneopterin aldolase
This is an abbreviated version!
For detailed information about dihydroneopterin aldolase, go to the full flat file.
Word Map on EC 4.1.2.25
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4.1.2.25
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folate
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dhnas
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6-hydroxymethyl-7,8-dihydropterin
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folic
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pyrophosphokinase
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dihydropteroate
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pteridine
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cyclohydrolase
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tetrahydrofolate
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pneumocystis
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hydroxymethyldihydropterin
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epimerization
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tetrahydrobiopterin
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carinii
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aldolases
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octamer
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antifolate
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medicine
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pharmacology
- 4.1.2.25
- folate
-
dhnas
- 6-hydroxymethyl-7,8-dihydropterin
-
folic
-
pyrophosphokinase
- dihydropteroate
- pteridine
-
cyclohydrolase
- tetrahydrofolate
- pneumocystis
-
hydroxymethyldihydropterin
-
epimerization
- tetrahydrobiopterin
- carinii
- aldolases
-
octamer
- antifolate
- medicine
- pharmacology
Reaction
Synonyms
aldolase, dihydroneopterin, At3g11750, At5g62980, DHNA, DHNA-HPPK, dihydroneopterin aldolase, dihydroneopterin aldolase/epimerase, FASA, folA, FolB, FolB1, FolB2, MptD, Rv3607c
ECTree
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Systematic Name
Systematic Name on EC 4.1.2.25 - dihydroneopterin aldolase
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7,8-dihydroneopterin glycolaldehyde-lyase [6-(hydroxymethyl)-7,8-dihydropterin-forming]
The enzyme participates in folate (in bacteria, plants and fungi) and methanopterin (in archaea) biosynthesis. The enzymes from the bacterium Escherichia coli and the plant Arabidopsis thaliana also catalyse the epimerisation of the 2' hydroxy-group (EC 5.1.99.8, 7,8-dihydroneopterin epimerase) [2,3]. The enzyme from the bacterium Mycobacterium tuberculosis is trifunctional and also catalyses EC 5.1.99.8 and EC 1.13.11.81, 7,8-dihydroneopterin oxygenase [6]. The enzyme from the yeast Saccharomyces cerevisiae also catalyses the two subsequent steps in the folate biosynthesis pathway - EC 2.7.6.3, 2-amino-4-hydroxy-6-(hydroxymethyl)dihydropteridine diphosphokinase, and EC 2.5.1.15, dihydropteroate synthase [4].