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4.1.1.90: peptidyl-glutamate 4-carboxylase

This is an abbreviated version!
For detailed information about peptidyl-glutamate 4-carboxylase, go to the full flat file.

Word Map on EC 4.1.1.90

Reaction

peptidyl-4-carboxyglutamate
+
2,3-Epoxyphylloquinone
 +
H2O
=
peptidyl-glutamate
 +
CO2
 +
O2
 +
phylloquinol

Synonyms

carboxylase, Ci-GGC, gamma glutamyl carboxylase, gamma-carboxylase, gamma-glutamyl carboxylase, GGCX, glutamate carboxylase, matrix gamma-carboxyglutamate protein, matrix Gla protein, peptidyl-glutamate 4-carboxylase, peptidyl-glutamate 4-carboxylase (2-methyl-3-phytyl-1,4-naphthoquinone-epoxidizing), two-chain carboxylase, vitamin K carboxylase, vitamin K-dependent carboxylase, vitamin K-dependent gamma-glutamyl carboxylase, vitamin K-dependent gamma-glutamylcarboxylase, VKC, VKD carboxylase

ECTree

     4 Lyases
         4.1 Carbon-carbon lyases
             4.1.1 Carboxy-lyases
                4.1.1.90 peptidyl-glutamate 4-carboxylase

KM Value

KM Value on EC 4.1.1.90 - peptidyl-glutamate 4-carboxylase

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KM VALUE [mM]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.0017
28-residue peptides based on residues -18 to +10 of human proprothrombin
pH 7.0
-
0.3
CO2
pH 7.4
0.565
conotoxin epsilon-TxIX
pH 7.0
-
0.42 - 24.3
FLEEL
0.075
precursor analog containing 12 of the propeptide region
pH 7.0
-
0.074
precursor analog containing 29 amino acids of the propeptide region
pH 7.0
-
0.006
proFactor IX
pH 7.0
-
0.052
reduced vitamin K1
pH 7.0
0.0068
TVFLDHENANKILNRPKRANTBLEEVRK
carboxylase probe1, TVFLDHENANKILNRPKRANTBLEEVRK as a substrate
0.0038 - 0.097
vitamin KH2
0.0023 - 2.06
YVFLDHQDADANLILNRPKR
additional information
additional information
Km-values measured by hyperbolic weighted least-squares analysis
-