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4.1.1.90: peptidyl-glutamate 4-carboxylase

This is an abbreviated version!
For detailed information about peptidyl-glutamate 4-carboxylase, go to the full flat file.

Word Map on EC 4.1.1.90

Reaction

peptidyl-4-carboxyglutamate
+
2,3-Epoxyphylloquinone
 +
H2O
=
peptidyl-glutamate
 +
CO2
 +
O2
 +
phylloquinol

Synonyms

carboxylase, Ci-GGC, gamma glutamyl carboxylase, gamma-carboxylase, gamma-glutamyl carboxylase, GGCX, glutamate carboxylase, matrix gamma-carboxyglutamate protein, matrix Gla protein, peptidyl-glutamate 4-carboxylase, peptidyl-glutamate 4-carboxylase (2-methyl-3-phytyl-1,4-naphthoquinone-epoxidizing), two-chain carboxylase, vitamin K carboxylase, vitamin K-dependent carboxylase, vitamin K-dependent gamma-glutamyl carboxylase, vitamin K-dependent gamma-glutamylcarboxylase, VKC, VKD carboxylase

ECTree

     4 Lyases
         4.1 Carbon-carbon lyases
             4.1.1 Carboxy-lyases
                4.1.1.90 peptidyl-glutamate 4-carboxylase

Cloned

Cloned on EC 4.1.1.90 - peptidyl-glutamate 4-carboxylase

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CLONED (Commentary)
ORGANISM
UNIPROT
LITERATURE
expressed in 293 cells
expressed in baculovirus-infected insect cell. Produced His6-tagged carboxylase as a recombinant protein using a baculovirus expression system
expressed in Chinese hamster ovary cells with an immunodetectable octapeptide inserted at the amino-terminal ends
expressed in Sf9 cells
-
expression in COS cells or expressed in Sf21 insect cells
expression in Drosophila Schneider S2 cell
-
expression in Sf9 cell
-
expression of the cloned cDNA results in an increase in carboxylase activity in microsomes of transfected cells compared to mock-transfected cells
His6-tagged bovine liver carboxylase (His6-carboxylase) is produced in insect cells using a baculovirus expression system
mutational analysis is performed using an expression system lacking endogenous carboxylase. Construction of baculo viruses containing FLAG-tagged carboxylase mutants and expression in infected SF21 cells. Expresses the 758 amino acid human VKD carboxylase bearing a C-terminal extension of AAADYKDDDDK, where the last eight amino acids are the FLAG epitope
-