4.1.1.90: peptidyl-glutamate 4-carboxylase
This is an abbreviated version!
For detailed information about peptidyl-glutamate 4-carboxylase, go to the full flat file.
Word Map on EC 4.1.1.90
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4.1.1.90
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calcification
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co2
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ribulose
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biotin
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acetyl-coa
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phosphoenolpyruvate
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arterial
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ribulose-1,5-bisphosphate
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chloroplast
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rubisco
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warfarin
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coagulation
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osteocalcin
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epoxide
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bisphosphate
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1,5-bisphosphate
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propionyl
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spinach
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gamma-carboxylation
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osteopontin
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biotin-dependent
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gamma-carboxyglutamic
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4.1.1.39
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prothrombin
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propeptide
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rubp
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calcify
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osteoprotegerin
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acidemia
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rhodospirillum
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biotinidase
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propionyl-coa
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rubrum
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rbcl
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pepcs
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vkorc1
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fetuin-a
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accase
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photorespiration
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osteonectin
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phylloquinone
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crassulacean
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pseudoxanthoma
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undercarboxylated
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elasticum
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medicine
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co2-fixing
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carboxysomes
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flaveria
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synthesis
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carboxy-lyase
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phosphoribulokinase
- 4.1.1.90
- calcification
- co2
- ribulose
- biotin
- acetyl-coa
- phosphoenolpyruvate
- arterial
- ribulose-1,5-bisphosphate
- chloroplast
- rubisco
- warfarin
-
coagulation
- osteocalcin
- epoxide
-
bisphosphate
-
1,5-bisphosphate
-
propionyl
- spinach
-
gamma-carboxylation
- osteopontin
-
biotin-dependent
-
gamma-carboxyglutamic
-
4.1.1.39
- prothrombin
- propeptide
- rubp
-
calcify
- osteoprotegerin
- acidemia
- rhodospirillum
- biotinidase
- propionyl-coa
- rubrum
- rbcl
-
pepcs
- vkorc1
- fetuin-a
- accase
-
photorespiration
- osteonectin
- phylloquinone
-
crassulacean
-
pseudoxanthoma
-
undercarboxylated
- elasticum
- medicine
-
co2-fixing
- carboxysomes
- flaveria
- synthesis
-
carboxy-lyase
- phosphoribulokinase
Reaction
Synonyms
carboxylase, Ci-GGC, gamma glutamyl carboxylase, gamma-carboxylase, gamma-glutamyl carboxylase, GGCX, glutamate carboxylase, matrix gamma-carboxyglutamate protein, matrix Gla protein, peptidyl-glutamate 4-carboxylase, peptidyl-glutamate 4-carboxylase (2-methyl-3-phytyl-1,4-naphthoquinone-epoxidizing), two-chain carboxylase, vitamin K carboxylase, vitamin K-dependent carboxylase, vitamin K-dependent gamma-glutamyl carboxylase, vitamin K-dependent gamma-glutamylcarboxylase, VKC, VKD carboxylase
ECTree
4.1.1.90 peptidyl-glutamate 4-carboxylaseAdvanced search results
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results (Natural Substrates Products
Natural Substrates Products on EC 4.1.1.90 - peptidyl-glutamate 4-carboxylase
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NATURAL SUBSTRATE 
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
L-glutamate + CO2 + O2 + vitamin K hydroquinone
gamma-carboxy L-glutamate + vitamin K epoxide + H2O
L-glutamate + CO2 + O2 + vitamin K hydroquinone
gamma-carboxy-L-glutamate + vitamin K epoxide + H2O
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-
-
?
peptidyl-4-carboxyglutamate + 2,3-epoxyphylloquinone + H2O
peptidyl-glutamate + CO2 + O2 + phylloquinone
peptidyl-L-glutamate + CO2 + O2 + phylloquinone
peptidyl-4-carboxy L-glutamate + 2,3-epoxyphylloquinone + H2O
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-
-
-
?
L-glutamate + CO2 + O2 + vitamin K hydroquinone
gamma-carboxy L-glutamate + vitamin K epoxide + H2O
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-
-
?
L-glutamate + CO2 + O2 + vitamin K hydroquinone
gamma-carboxy L-glutamate + vitamin K epoxide + H2O
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-
-
-
?
L-glutamate + CO2 + O2 + vitamin K hydroquinone
gamma-carboxy L-glutamate + vitamin K epoxide + H2O
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-
-
?
L-glutamate + CO2 + O2 + vitamin K hydroquinone
gamma-carboxy L-glutamate + vitamin K epoxide + H2O
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-
-
-
?
L-glutamate + CO2 + O2 + vitamin K hydroquinone
gamma-carboxy L-glutamate + vitamin K epoxide + H2O
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-
-
?
peptidyl-4-carboxyglutamate + 2,3-epoxyphylloquinone + H2O
peptidyl-glutamate + CO2 + O2 + phylloquinone
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-
-
-
?
peptidyl-4-carboxyglutamate + 2,3-epoxyphylloquinone + H2O
peptidyl-glutamate + CO2 + O2 + phylloquinone
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-
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?
additional information
?
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enzyme catalyzes the posttranslational modification of specific glutamic acid residues to form gamma-carboxygutamic acid residues within the vitamin K-dependent proteins
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-
?
additional information
?
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enzyme catalyzes the posttranslational modification of specific glutamic acid residues to form gamma-carboxygutamic acid residues within the vitamin K-dependent proteins
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-
?
additional information
?
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enzyme required for the posttranslational modification of vitamin K-dependent proteins
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-
?
additional information
?
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enzyme required for the posttranslational modification of vitamin K-dependent proteins
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-
?
additional information
?
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vitamin K-dependent carboxylation of glutamate to form gamma-carboxyglutamate (Gla) is unusual among known posttranslational modifications in that substrate recognition does not require a specific sequence around the glutamate residues to be modified
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-
?
additional information
?
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one of the most distinctive of the extracellular post-translational modifications is the vitamin K-dependent gamma-carboxylation of glutamate residues to give gamma-carboxyglutamate
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-
?
additional information
?
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one of the most distinctive of the extracellular post-translational modifications is the vitamin K-dependent gamma-carboxylation of glutamate residues to give gamma-carboxyglutamate
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-
?
additional information
?
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enzyme accomplishes the post-translational modification required for the activity of all of the vitamin K-dependent proteins
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-
?
additional information
?
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enzyme accomplishes the post-translational modification required for the activity of all of the vitamin K-dependent proteins
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-
?
additional information
?
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enzyme important for gamma-carboxylation of gla-proteins
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-
?
additional information
?
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uses the oxygenation of vitamin K to convert glutamyl residues to gamma-carboxylated glutamyl residues in vitamin Kdependent proteins
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-
?
additional information
?
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vitamin K-dependent carboxylation of glutamate to form gamma-carboxyglutamate (Gla) is unusual among known posttranslational modifications in that substrate recognition does not require a specific sequence around the glutamate residues to be modified
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-
?
additional information
?
-
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vitamin K-dependent proteins require carboxylation for activity
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-
?
additional information
?
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an essential posttranslational modification required for the biological activity of a number of proteins, including proteins involved in blood coagulation and its regulation
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?
additional information
?
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cis-isomer of vitamin K1, the 2-desmethyl derivative of phylloquinone, MK-1, or menadione (2 -methyl-1,4-naphthoquinone) have little or no activity
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-
?
