4.1.1.90: peptidyl-glutamate 4-carboxylase
This is an abbreviated version!
For detailed information about peptidyl-glutamate 4-carboxylase, go to the full flat file.
Word Map on EC 4.1.1.90
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4.1.1.90
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calcification
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co2
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ribulose
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biotin
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acetyl-coa
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phosphoenolpyruvate
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arterial
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ribulose-1,5-bisphosphate
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chloroplast
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rubisco
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warfarin
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coagulation
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osteocalcin
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epoxide
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bisphosphate
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1,5-bisphosphate
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propionyl
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spinach
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gamma-carboxylation
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osteopontin
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biotin-dependent
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gamma-carboxyglutamic
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4.1.1.39
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prothrombin
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propeptide
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rubp
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calcify
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osteoprotegerin
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acidemia
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rhodospirillum
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biotinidase
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propionyl-coa
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rubrum
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rbcl
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pepcs
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vkorc1
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fetuin-a
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accase
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photorespiration
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osteonectin
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phylloquinone
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crassulacean
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pseudoxanthoma
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undercarboxylated
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elasticum
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medicine
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co2-fixing
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carboxysomes
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flaveria
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synthesis
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carboxy-lyase
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phosphoribulokinase
- 4.1.1.90
- calcification
- co2
- ribulose
- biotin
- acetyl-coa
- phosphoenolpyruvate
- arterial
- ribulose-1,5-bisphosphate
- chloroplast
- rubisco
- warfarin
-
coagulation
- osteocalcin
- epoxide
-
bisphosphate
-
1,5-bisphosphate
-
propionyl
- spinach
-
gamma-carboxylation
- osteopontin
-
biotin-dependent
-
gamma-carboxyglutamic
-
4.1.1.39
- prothrombin
- propeptide
- rubp
-
calcify
- osteoprotegerin
- acidemia
- rhodospirillum
- biotinidase
- propionyl-coa
- rubrum
- rbcl
-
pepcs
- vkorc1
- fetuin-a
- accase
-
photorespiration
- osteonectin
- phylloquinone
-
crassulacean
-
pseudoxanthoma
-
undercarboxylated
- elasticum
- medicine
-
co2-fixing
- carboxysomes
- flaveria
- synthesis
-
carboxy-lyase
- phosphoribulokinase
Reaction
Synonyms
carboxylase, Ci-GGC, gamma glutamyl carboxylase, gamma-carboxylase, gamma-glutamyl carboxylase, GGCX, glutamate carboxylase, matrix gamma-carboxyglutamate protein, matrix Gla protein, peptidyl-glutamate 4-carboxylase, peptidyl-glutamate 4-carboxylase (2-methyl-3-phytyl-1,4-naphthoquinone-epoxidizing), two-chain carboxylase, vitamin K carboxylase, vitamin K-dependent carboxylase, vitamin K-dependent gamma-glutamyl carboxylase, vitamin K-dependent gamma-glutamylcarboxylase, VKC, VKD carboxylase
ECTree
4.1.1.90 peptidyl-glutamate 4-carboxylaseAdvanced search results
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results (Activating Compound
Activating Compound on EC 4.1.1.90 - peptidyl-glutamate 4-carboxylase
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ACTIVATING COMPOUND 
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
IMAGE
benzoylphenylalanine
Bpa, the four Bpa peptides enhance gamma-carboxylation by 1.5-2.3fold, and the rate enhancement profiles are very similar to that of proFIX19, showing that these propeptides are recognized by the carboxylase
FLEEL
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the enzyme activity increases with increasing FLEEL peptide concentration up to 1.2 mM
N-ethyl-2-(3-methyl-1,4-dioxo-1,4-dihydronaphthalen-2-yl)hexadecylamide
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2fold higher carboxylated osteocalcin synthesis in MG-63 cells in presence of the compound than with menaquinone-4. No cytotoxicity observed with concentrations up to 500 nM
proFIX19
enhances gamma-carboxylation of the synthetic FLEEL peptide by 2.2-2.3fold
proPT18
enhances gamma-carboxylation of the synthetic FLEEL peptide by 2.2-2.3fold
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additional information
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enzyme activity increases 2-3fold by a vitamin K deficiency or Warfarin treatment
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N-ethyl-2-(3-methyl-1,4-dioxo-1,4-dihydronaphthalen-2-yl)tetradecylamide
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2.5fold higher carboxylated osteocalcin synthesis in MG-63 cells in presence of the compound than with menaquinone-4, No cytotoxicity observed with concentrations up to 500 nM
N-ethyl-2-(3-methyl-1,4-dioxo-1,4-dihydronaphthalen-2-yl)tetradecylamide
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