4.1.1.50: adenosylmethionine decarboxylase
This is an abbreviated version!
For detailed information about adenosylmethionine decarboxylase, go to the full flat file.
Word Map on EC 4.1.1.50
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4.1.1.50
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polyamine
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spermidine
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putrescine
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methylglyoxal
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bisguanylhydrazone
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diamine
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alpha-difluoromethylornithine
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brucei
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prostate
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decarboxylases
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l-ornithine
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trypanosoma
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n1-acetyltransferase
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antiproliferative
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proenzyme
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pyruvoyl
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aminopropyltransferases
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agmatine
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agriculture
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1,3-diaminopropane
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synthesis
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pentamidine
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trypanosomatids
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n1-acetylspermidine
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medicine
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pao
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pharmacology
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adenosyltransferase
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antizyme
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dl-alpha-difluoromethylornithine
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glyoxal
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drought
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rhodesiense
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trypanosomiasis
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analysis
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trypanothione
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guanylhydrazone
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difluoromethylornithine
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uorfs
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normfinder
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methylthioadenosine
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biotechnology
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arginase
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polyamine-depleted
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cadaverine
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genorm
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berenil
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enzyme-activated
- 4.1.1.50
- polyamine
- spermidine
- putrescine
- methylglyoxal
- bisguanylhydrazone
- diamine
- alpha-difluoromethylornithine
- brucei
- prostate
- decarboxylases
- l-ornithine
- trypanosoma
-
n1-acetyltransferase
-
antiproliferative
- proenzyme
-
pyruvoyl
- aminopropyltransferases
- agmatine
- agriculture
- 1,3-diaminopropane
- synthesis
- pentamidine
-
trypanosomatids
- n1-acetylspermidine
- medicine
- pao
- pharmacology
-
adenosyltransferase
- antizyme
- dl-alpha-difluoromethylornithine
- glyoxal
- drought
- rhodesiense
- trypanosomiasis
- analysis
- trypanothione
-
guanylhydrazone
- difluoromethylornithine
-
uorfs
-
normfinder
- methylthioadenosine
- biotechnology
- arginase
-
polyamine-depleted
- cadaverine
-
genorm
- berenil
-
enzyme-activated
Reaction
Synonyms
Ado-MetDC, AdoMet decarboxylase, AdoMetDC, AdoMetDC/ODC, AMDC, BjSAMDC1, BjSAMDC2, BjSAMDC3, BjSAMDC4, BlsE, Bud2, MdSAMDC1, MdSAMDC2, OsSAMDC, PfAdoMetDC, protein SSO0585, S-adenosyl methionine decarboxylase, S-Adenosyl-L-methionine decarboxylase, S-adenosyl-methionine-decarboxylase, S-adenosylmethionine decarboxy-lase/ornithine decarboxylase, S-Adenosylmethionine decarboxylase, S-adenosylmethionine decarboxylase 1, S-adenosylmethionine decarboxylase 2, S-adenosylmethionine decarboxylase 3, S-adenosylmethionine decarboxylase 4, SAM decarboxylase, SAM-DC, SAMDC, SvPEPC, Tb927.6.4410
ECTree
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KM Value
KM Value on EC 4.1.1.50 - adenosylmethionine decarboxylase
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0.00193
wild type enzyme, in 50 mM HEPES buffer (pH 8.0), at 25°C
0.00196
S-adenosyl-L-methionine
mutant enzyme M37Y, in 50 mM HEPES buffer (pH 8.0), at 25°C
0.00204
S-adenosyl-L-methionine
mutant enzyme M37W, in 50 mM HEPES buffer (pH 8.0), at 25°C
0.00215
S-adenosyl-L-methionine
mutant enzyme M37F, in 50 mM HEPES buffer (pH 8.0), at 25°C
0.043
S-adenosyl-L-methionine
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bifunctional AdoMetDC/ODC enzyme, in 50 mM KH2PO4 pH 7.5, 1 mM EDTA, 1 mM dithiothreitol, at 37°C
0.058
S-adenosyl-L-methionine
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native wild type AdoMetDC enzyme, in 50 mM KH2PO4 pH 7.5, 1 mM EDTA, 1 mM dithiothreitol, at 37°C
0.11
S-adenosyl-L-methionine
A5HNV7
enzyme in complex with prozyme, absence of putrescine, 37°C, pH 8.0
0.14
S-adenosyl-L-methionine
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wild type homodimeric enzyme, with 5 mM putrescine, at pH 8.0 and 37°C
0.17
S-adenosyl-L-methionine
A5HNV7
enzyme in complex with prozyme, presence of putrescine, 37°C, pH 8.0
0.24
S-adenosyl-L-methionine
A5HNV7
free enzyme, presence of putrescine, 37°C, pH 8.0
0.25
S-adenosyl-L-methionine
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recombinant AdoMetDC enzyme, in 50 mM KH2PO4 pH 7.5, 1 mM EDTA, 1 mM dithiothreitol, at 37°C
0.38
S-adenosyl-L-methionine
A5HNV7
free enzyme, absence of putrescine, 37°C, pH 8.0
0.4
S-adenosyl-L-methionine
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wild type homodimeric enzyme, without putrescine, at pH 8.0 and 37°C
additional information
additional information
addition of putrescine increases Km up to 2-fold
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additional information
additional information
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addition of putrescine increases Km up to 2-fold
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additional information
additional information
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ratio of kcat/Km value, wild-type 3.5 per M and s in absence, 100 per M and s in presence of putrescine, mutant S111R 2.0 per M and s in absence, 6.4 per M and s in presence of putrescine, mutant D174V 36.6 per M and s in absence, 5 per M and s in presence of putrescine, mutant F285 1.8 per M and s in absence, 650 per M and s in presence of putrescine
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