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Literature summary for 4.1.1.50 extracted from
- Comparison of S-adenosylmethionine decarboxylase from rat liver and muscle (1982), Biochemistry, 21, 3116-3122.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| 1,3-diaminopropane | enzyme from psoas is stimulated more than enzyme from liver | Rattus norvegicus |  |
| putrescine | stimulation | Rattus norvegicus | |
| putrescine | 0.25 mM required for maximal activation | Rattus norvegicus | |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| Dimethylglyoxal bis(guanylhydrazone) | - |
Rattus norvegicus | |
| ethylglyoxal bis(guanylhydrazone) | - |
Rattus norvegicus | |
| methylglyoxal bis(guanylhydrazone) | - |
Rattus norvegicus | |
| n-Butylglyoxal bis(guanylhydrazone) | - |
Rattus norvegicus | |
| Pentane dialdehyde bis(guanylhydrazone) | weak | Rattus norvegicus | |
| Propane dialdehyde bis(guanylhydrazone) | weak | Rattus norvegicus | |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.05 | - |
S-adenosyl-L-methionine | enzyme from liver | Rattus norvegicus | |
| 0.1 | - |
S-adenosyl-L-methionine | enzyme from psoas | Rattus norvegicus | |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 32500 | - |
2 * 32500, SDS-PAGE | Rattus norvegicus |
| 68000 | - |
gel filtration | Rattus norvegicus |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Rattus norvegicus | - |
- |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
- |
Rattus norvegicus |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| liver | - |
Rattus norvegicus | - |
| muscle | - |
Rattus norvegicus | - |
| psoas | - |
Rattus norvegicus | - |
Specific Activity [micromol/min/mg]
| Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|
| additional information | - |
- |
Rattus norvegicus |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| S-adenosyl-L-methionine | - |
Rattus norvegicus | (5-deoxy-5-adenosyl)(3-aminopropyl)methylsulfonium salt + CO2 | - |
? | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| dimer | 2 * 32500, SDS-PAGE | Rattus norvegicus |
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