Reference on EC 4.1.1.50 - adenosylmethionine decarboxylase
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REF. 
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Anton, D.L.; Kutny, R.
Mechanism of substrate inactivation of Escherichia coli S-adenosylmethionine decarboxylase
Biochemistry
26
6444-6447
1987
Escherichia coli
Paulin, L.; Brander, E.; Pösö, H.
Ornithine decarboxylase, S-adenosyl-L-methionine decarboxylase and arginine decarboxylase from Mycobacterium bovis (BCG)
Experientia
43
174-176
1987
Mycobacterium tuberculosis variant bovis
Anton, D.L.; Kutny, R.
Escherichia coli S-adenosylmethionine decarboxylase. Subunit structure, reductive amination, and NH2-terminal sequences
J. Biol. Chem.
262
2817-2822
1987
Escherichia coli, Escherichia coli HT527
Paulin, L.
The effects of 1-aminooxy-3-aminopropane and S-(5'-deoxy-5'-adenosyl)methylthioethylhydroxylamine on ornithine decarboxylase and S-adenosyl-L-methionine decarboxylase from Escherichia coli
FEBS Lett.
202
323-326
1986
Escherichia coli
Bitonti, A.J.; Dumont, J.A.; McCann, P.P.
Characterization of Trypanosoma brucei brucei S-adenosyl-L-methionine decarboxylase and its inhibition by berenil, pentamidine and methylglyoxal bis(guanylhydrazone)
Biochem. J.
237
685-689
1986
Trypanosoma brucei
Jänne, J.; Alhonen-Hongisto, L.; Nikula, P.; Elo, H.
S-Adenosylmethionine decarboxylase as target of chemotherapy
Adv. Enzyme Regul.
24
125-139
1985
Mus musculus
Yamanoha, B.; Cohen, S.S.
S-Adenosylmethionine decarboxylase and spermidine synthase from Chineses cabbage
Plant Physiol.
78
784-790
1985
Brassica rapa subsp. pekinensis
Shirahata, A.; Christman, K.L.; Pegg, A.E.
Quantitation of S-adenosylmethionine decarboxylase protein
Biochemistry
24
4417-4423
1985
Mus musculus, Rattus norvegicus
White Tabor, C.; Tabor, H.
Methionine adenosyltransferase (S-adenosylmethionine synthetase) and S-adenosylmethionine decarboxylase
Adv. Enzymol. Relat. Areas Mol. Biol.
56
251-282
1984
Bos taurus, Saccharomyces cerevisiae, Escherichia coli, Homo sapiens, Lytechinus pictus, Mus musculus, Rattus norvegicus
Pegg, A.E.
Inhibitors of S-adenosylmethionine decarboxylase
Methods Enzymol.
94
239-247
1983
Rattus norvegicus
Pegg, A.E.; Pösö, H.
S-Adenosylmethionine decarboxylase (rat liver)
Methods Enzymol.
94
234-239
1983
Rattus norvegicus
Cohn, M.S.; Tabor, C.W.; Tabor, H.
S-Adenosylmethionine decarboxylase (Saccharomyces cerevisiae)
Methods Enzymol.
94
231-234
1983
Saccharomyces cerevisiae
Markham, G.D.; Tabor, C.W.; Tabor, H.
S-Adenosylmethionine decarboxylase (Escherichia coli)
Methods Enzymol.
94
228-230
1983
Escherichia coli
Pösö, H.; Pegg, A.E.
Comparison of S-adenosylmethionine decarboxylase from rat liver and muscle
Biochemistry
21
3116-3122
1982
Rattus norvegicus
Suzuki, Y.; Hirasawa, E.
S-Adenosylmethionine decarboxylase of corn seedlings
Plant Physiol.
66
1091-1094
1980
Zea mays
Sakai, T.; Hori, C.; Kano, K.; Oka, T.
Purification and characterization of S-adenosyl-L-methionine decarboxylase from mouse mammary gland and liver
Biochemistry
18
5541-5548
1979
Mus musculus
Pösö, H.; Sinervirta, R.; Jänne, J.
S-Adenosylmethionine decarboxylase from baker's yeast
Biochem. J.
151
67-73
1975
Saccharomyces cerevisiae
Pegg, A.E.
Purification and rat liver S-adenosyl-L-methionine decarboxylase
Biochem. J.
141
581-583
1974
Rattus norvegicus
Manen, C.A.; Russell, D.H.
Comparative properties of rat liver and sea urchin eggs S-adenosyl-L-methionine decarboxylase
Biochemistry
13
4729-4735
1974
Lytechinus pictus, Rattus norvegicus
Feldman, M.J.; Levy, C.C.; Rusell, D.H.
Purification and characterization of S-adenosyl-L-methionine decarboxylase from rat liver
Biochemistry
11
671-677
1972
Rattus norvegicus
Wickner, R.B.; Tabor, C.W.; Tabor, H.
Adenosylmethionine decarboxylase (Escherichia coli W)
Methods Enzymol.
17B
647-651
1971
Escherichia coli
-
Tabor, C.W.
Adenosylmethionine decarboxylase
Methods Enzymol.
5
756-760
1962
Escherichia coli
-
Kameij, T.; Pegg, A.E.
Effect of putrescine on the synthesis of S-adenosylmethionine decarboxylase
Biochem. J.
243
285-288
1987
Rattus norvegicus
Nishimura, K.; Liisanantti, M.; Muta, Y.; Kashiwagi, K.; Shirahata, A.; Jänne, M.; Kankare, K.; Jänne, O.A.; Igarashi, K.
Structure and activity of mouse S-adenosylmethionine decarboxylase gene promoters and properties of the encoded proteins
Biochem. J.
332
651-659
1998
Mus musculus (P0DMN7), Mus musculus
Persson, K.; Aslund, L.; Grahn, B.; Hanke, J.; Heby, O.
Trypanosoma cruzi has not lost its S-adenosylmethionine decarboxylase: characterization of the gene and the encoded enzyme
Biochem. J.
333
527-537
1998
Trypanosoma cruzi
Da'dara, A.A.; Walter, R.D.
Molecular and biochemical characterization of S-adenosylmethionine decarboxylase from free-living nematode Caenorhabditis elegans
Biochem. J.
336
545-550
1998
Caenorhabditis elegans (O02655), Caenorhabditis elegans
Manni, A.; Badger, B.; Grove, R.; Kunselman, S.; Demers, L.
Isolation and characterization of human breast cancer cell overexpressing S-adenosylmethionine decarboxylase
Cancer Lett.
95
23-28
1995
Homo sapiens
Da'dara, A.A.; Mett, H.; Walter, R.D.
MGBG analogues as potent inhibitors of S-adenosylmethionine decarboxylase of Onchocerca volvulus
Mol. Biochem. Parasitol.
97
13-19
1998
Onchocerca volvulus
Shantz, L.M.; Stanley, B.A.; Secrist III, J.A.; Pegg, A.E.
Purification of human S-adenosylmethionine decarboxylase expressed in Escherichia coli and use of this protein to investigate the mechanism of inhibition by the irreversible inhibitors, 5'-deoxy-5'-[(3-hydrazinopropyl)methylamino]adenosine and 5'-[[(Z)-4-amino-2-butenyl]methylamino]-5'-deoxyadenosine
Biochemistry
31
6848-6855
1992
Homo sapiens
Regenass, U.; Caravatti, G.; Mett, M.; Stanek, J.; Schneider, P.; Mueller, M.; Matter, A.; Vertino, P.; Porter, C.W.
New S-adenosylmethionine decarboxylase inhibitors with potent antitumor activity
Cancer Res.
52
4712-4718
1992
Homo sapiens, Mus musculus
Regenass, U.; Mett, H.; Stanek, J.; Mueller, M.; Kramer, D.; Porter, C.W.
CGP 48664, a new S-adenosylmethionine decarboxylase inhibitor with broad spectrum antiproliferative and antitumor activity
Cancer Res.
54
3210-3217
1994
Homo sapiens, Mus musculus
Yang, Y.G.; Cho, Y.D.
Purification of S-adenosylmethionine decarboxylase from soybean
Biochem. Biophys. Res. Commun.
181
1181-1186
1991
Glycine max
Danzin, C.; Marchal, P.; Casara, P.
Irreversible inhibition of rat S-adenosylmethionine decarboxylase by 5'-{[(Z)-4-amino-2-butenyl]methylamino}-5'deoxyadenosine
Biochem. Pharmacol.
40
1499-1503
1990
Rattus norvegicus
White, E.L.; Arnett, G.; Secrist III, J.A.; Shannon, W.M.
Characterization of S-adenosylmethionine decarboxylase induced by human cytomegalovirus infection
Virus Res.
31
255-263
1994
Homo sapiens
Hugo, E.R.; Byers, T.J.
S-Adenosyl-L-methionine decarboxylase of Acanthamoeba castellanii (Neff): purification and properties
Biochem. J.
295
203-209
1993
Acanthamoeba castellanii, Acanthamoeba castellanii NEFF
Cacciapuoti, G.; Porcelli, M.; de Rosa, M.; Gambacorta, A.; Bertoldo, C.; Zappia, V.
S-Adenosylmethionine decarboxylase from the thermophilic archaebacterium Sulfolobus solfataricus
Eur. J. Biochem.
199
395-400
1991
Saccharolobus solfataricus
Autelli, R.; Stjernborg, L.; Khomutov, A.R.; Khomutov, R.M.; Persson, L.
Regulation of S-adenosylmethionine decarboxylase in L1210 leukemia cells
Eur. J. Biochem.
196
551-556
1991
Mus musculus
Ferioli, M.E.; Candiani, R.; Rocca, E.; Scalabrino, G.
Changes in inhibition of S-adenosyl-L-methionine decarboxylase in regenerating rat liver
Biogenic Amines
6
513-524
1989
Rattus norvegicus
-
Loeser, C.; Fitting, T.; Fölsch, U.R.
Importance of intracellular S-adenosylmethionine decarboxylase activity for regulation of camostate-induced pancreatic polyamine metabolism and growth: In vivo effect of two novel S-adenosylmethionine decarboxylase inhibitors
Digestion
58
258-265
1997
Rattus norvegicus
Svensson, F.; Mett, H.; Persson, L.
CGP 48664, a potent and specific S-adenosylmethionine decarboxylase inhibitor: effects on regulation and stability of the enzyme
Biochem. J.
322
297-302
1997
Mus musculus
Birkholtz, L.M.; Wrenger, C.; Joubert, F.; Wells, G.A.; Walter, R.D.; Louw, A.I.
Parasite-specific inserts in the bifunctional S-adenosylmethionine decarboxylase/ornithine decarboxylase of Plasmodium falciparum modulate catalytic activities and domain interactions
Biochem. J.
377
439-448
2004
Plasmodium falciparum (Q9U8D4), Plasmodium falciparum
Xiong, H.; Stanley, B.A.; Pegg, A.E.
Role of cysteine-82 in the catalytic mechanism of human S-adenosylmethionine decarboxylase
Biochemistry
38
2462-2470
1999
Homo sapiens
Kinch, L.N.; Phillips, M.A.
Single-turnover kinetic analysis of Trypanosoma cruzi S-adenosylmethionine decarboxylase
Biochemistry
39
3336-3343
2000
Trypanosoma cruzi
Tolbert, W.D.; Ekstrom, J.L.; Mathews, II; Secrist, J.A., 3rd; Kapoor, P.; Pegg, A.E.; Ealick, S.E.
The structural basis for substrate specificity and inhibition of human S-adenosylmethionine decarboxylase
Biochemistry
40
9484-9494
2001
Homo sapiens (P17707), Homo sapiens
Clyne, T.; Kinch, L.N.; Phillips, M.A.
Putrescine activation of Trypanosoma cruzi S-adenosylmethionine decarboxylase
Biochemistry
41
13207-13216
2002
Trypanosoma cruzi
Bennett, E.M.; Ekstrom, J.L.; Pegg, A.E.; Ealick, S.E.
Monomeric S-adenosylmethionine decarboxylase from plants provides an alternative to putrescine stimulation
Biochemistry
41
14509-14517
2002
Solanum tuberosum (Q04694), Solanum tuberosum
Ndjonka, D.; Zou, Y.; Bi, X.; Woster, P.; Walter, R.D.; Luersen, K.
The activator-binding site of Onchocerca volvulus S-adenosylmethionine decarboxylase, a potential drug target
Biol. Chem.
384
1195-1201
2003
Homo sapiens, Onchocerca volvulus
Ndjonka, D.; Da'dara, A.; Walter, R.D.; Luersen, K.
Caenorhabditis elegans S-adenosylmethionine decarboxylase is highly stimulated by putrescine but exhibits a low specificity for activator binding
Biol. Chem.
384
83-91
2003
Caenorhabditis elegans
Nasizadeh, S.; Persson, L.
Extremely rapid turnover of S-adenosylmethionine decarboxylase in Crithidia fasciculata
FEBS Lett.
553
131-134
2003
Crithidia fasciculata
Nishimura, K.; Nakatsu, F.; Kashiwagi, K.; Ohno, H.; Saito, T.; Igarashi, K.
Essential role of S-adenosylmethionine decarboxylase in mouse embryonic development
Genes Cells
7
41-47
2002
Mus musculus
Kim, A.D.; Graham, D.E.; Seeholzer, S.H.; Markham, G.D.
S-Adenosylmethionine decarboxylase from the archaeon Methanococcus jannaschii: identification of a novel family of pyruvoyl enzymes
J. Bacteriol.
182
6667-6672
2000
Methanocaldococcus jannaschii
Park, S.J.; Cho, Y.D.
Identification of functionally important residues of Arabidopsis thaliana S-adenosylmethionine decarboxylase
J. Biochem.
126
996-1003
1999
Arabidopsis thaliana (Q96286), Arabidopsis thaliana
Park, S.J.; Cho, Y.D.
Studies on the active site of the Arabidopsis thaliana S-adenosylmethionine decarboxylase: Lys81 residue involvement in catalytic activity
J. Biochem. Mol. Biol.
33
69-74
2000
Arabidopsis thaliana (Q96286)
-
Park, S.J.; Cho, Y.D.
Structural roles of cysteine 50 and cysteine 230 residues in Arabidopsis thaliana S-adenosylmethionine decarboxylase
J. Biochem. Mol. Biol.
35
178-185
2002
Arabidopsis thaliana (Q96286), Arabidopsis thaliana
Lu, Z.J.; Markham, G.D.
Catalytic properties of the archaeal S-adenosylmethionine decarboxylase from Methanococcus jannaschii
J. Biol. Chem.
279
265-273
2004
Methanocaldococcus jannaschii
Kinch, L.N.; Scott, J.R.; Ullman, B.; Phillips, M.A.
Cloning and kinetic characterization of the Trypanosoma cruzi S-adenosylmethionine decarboxylase
Mol. Biochem. Parasitol.
101
1-11
1999
Trypanosoma cruzi (O76240), Trypanosoma cruzi
Taladriz, S.; Ramiro, M.J.; Hanke, T.; Larraga, V.
S-adenosylmethionine decarboxylase from Leishmania infantum promastigotes: molecular cloning and differential expression
Parasitol. Res.
88
421-426
2002
Leishmania infantum
Thu-Hang, P.; Bassie, L.; Safwat, G.; Trung-Nghia, P.; Christou, P.; Capell, T.
Expression of a heterologous S-adenosylmethionine decarboxylase cDNA in plants demonstrates that changes in S-adenosyl-L-methionine decarboxylase activity determine levels of the higher polyamines spermidine and spermine
Plant Physiol.
129
1744-1754
2002
Datura stramonium (Q96555), Datura stramonium
Li, Y.F.; Hess, S.; Pannell, L.K.; Tabor, C.W.; Tabor, H.
In vivo mechanism-based inactivation of S-adenosylmethionine decarboxylases from Escherichia coli, Salmonella typhimurium, and Saccharomyces cerevisiae
Proc. Natl. Acad. Sci. USA
98
10578-10583
2001
Escherichia coli, Salmonella enterica subsp. enterica serovar Typhimurium, Saccharomyces cerevisiae (P21182), Saccharomyces cerevisiae
Chen, L.M.; Li, K.Z.; Miwa, T.; Izui, K.
Overexpression of a cyanobacterial phosphoenolpyruvate carboxylase with diminished sensitivity to feedback inhibition in Arabidopsis changes amino acid metabolism
Planta
219
440-449
2004
Thermostichus vulcanus
Nisenberg, O.; Pegg, A.E.; Welsh, P.A.; Keefer, K.; Shantz, L.M.
Overproduction of cardiac S-adenosylmethionine decarboxylase in transgenic mice
Biochem. J.
393
295-302
2006
Mus musculus
Nummela, P.; Yin, M.; Kielosto, M.; Leaner, V.; Birrer, M.J.; Holtta, E.
Thymosin beta4 is a determinant of the transformed phenotype and invasiveness of S-adenosylmethionine decarboxylase-transfected fibroblasts
Cancer Res.
66
701-712
2006
Homo sapiens
Greco, A.; Calle, A.; Morfin, F.; Thouvenot, D.; Cayre, M.; Kindbeiter, K.; Martin, L.; Levillain, O.; Diaz, J.J.
S-adenosyl methionine decarboxylase activity is required for the outcome of herpes simplex virus type 1 infection and represents a new potential therapeutic target
FASEB J.
19
1128-1130
2005
Homo sapiens
Hao, Y.J.; Zhang, Z.; Kitashiba, H.; Honda, C.; Ubi, B.; Kita, M.; Moriguchi, T.
Molecular cloning and functional characterization of two apple S-adenosylmethionine decarboxylase genes and their different expression in fruit development, cell growth and stress responses
Gene
350
41-50
2005
Malus domestica (Q852S8), Malus domestica, Malus sylvestris (Q852S9)
Toms, A.V.; Kinsland, C.; McCloskey, D.E.; Pegg, A.E.; Ealick, S.E.
Evolutionary links as revealed by the structure of Thermotoga maritima S-adenosylmethionine decarboxylase
J. Biol. Chem.
279
33837-33846
2004
Thermotoga maritima
Lam, K.; Zhang, L.; Bewick, M.; Lafrenie, R.M.
HSG cells differentiated by culture on extracellular matrix involves induction of S-adenosylmethione decarboxylase and ornithine decarboxylase
J. Cell. Physiol.
203
353-361
2005
Homo sapiens
Wells, G.A.; Birkholtz, L.M.; Joubert, F.; Walter, R.D.; Louw, A.I.
Novel properties of malarial S-adenosylmethionine decarboxylase as revealed by structural modelling
J. Mol. Graph. Model.
24
307-318
2006
Plasmodium falciparum
Torrigiani, P.; Scaramagli, S.; Ziosi, V.; Mayer, M.; Biondi, S.
Expression of an antisense Datura stramonium S-adenosylmethionine decarboxylase cDNA in tobacco: changes in enzyme activity, putrescine-spermidine ratio, rhizogenic potential, and response to methyl jasmonate
J. Plant Physiol.
162
559-571
2005
Datura stramonium (Q96555), Datura stramonium
Pillai, M.A.; Akiyama, T.
Differential expression of an S-adenosyl-L-methionine decarboxylase gene involved in polyamine biosynthesis under low temperature stress in japonica and indica rice genotypes
Mol. Genet. Genomics
271
141-149
2004
Oryza sativa
Hu, W.W.; Gong, H.; Pua, E.C.
Molecular cloning and characterization of S-adenosylmethionine decarboxylase genes from mustard (Brassica juncea)
Physiol. Plant.
124
25-40
2005
Brassica juncea (O49972), Brassica juncea (Q42613), Brassica juncea (Q6QJ69), Brassica juncea (Q9SDM8)
-
Hu, W.W.; Gong, H.; Pua, E.C.
The pivotal roles of the plant S-adenosylmethionine decarboxylase 5' untranslated leader sequence in regulation of gene expression at the transcriptional and posttranscriptional levels
Plant Physiol.
138
276-286
2005
Arabidopsis thaliana
Tian, H.; Liu, X.; Zhang, B.; Sun, Q.; Sun, D.
Adenovirus-mediated expression of both antisense ornithine decarboxylase and S-adenosylmethionine decarboxylase inhibits lung cancer cell growth
Acta Biochim. Biophys. Sin.
39
423-430
2007
Homo sapiens
Kim, J.S.; Kim, T.L.; Kim, K.C.; Choe, C.; Chung, H.W.; Cho, E.W.; Kim, I.G.
S-Adenosylmethionine decarboxylase partially regulates cell growth of HL-60 cells by controlling the intracellular ROS level: Early senescence and sensitization to gamma-radiation
Arch. Biochem. Biophys.
456
58-70
2006
Homo sapiens (P17707)
Beswick, T.C.; Willert, E.K.; Phillips, M.A.
Mechanisms of allosteric regulation of Trypanosoma cruzi S-adenosylmethionine decarboxylase
Biochemistry
45
7797-7807
2006
Trypanosoma cruzi
Lu, Z.J.; Markham, G.D.
Metal ion activation of S-adenosylmethionine decarboxylase reflects cation charge density
Biochemistry
46
8172-8180
2007
Escherichia coli
Ge, C.; Cui, X.; Wang, Y.; Hu, Y.; Fu, Z.; Zhang, D.; Cheng, Z.; Li, J.
BUD2, encoding an S-adenosylmethionine decarboxylase, is required for Arabidopsis growth and development
Cell Res.
16
446-456
2006
Arabidopsis thaliana (Q3E9D5)
Gong, L.; Zhang, B.; Zhang, Y.; Hu, H.; Zhao, Z.; Liu, X.
Cloning, expression and purification of human S-adenosylmethionine decarboxylase gene alpha subunit
Chin. J. Physiol.
50
29-33
2007
Homo sapiens
Jang, S.; Park, K.Y.; Gi, G.; Choi, K.; Choi, S.K.; Kim, Y.
Involvement of spermine and S-adenosylmethionine decarboxylase in postharvest longevity of cut rose flowers
Hortic. Environ. Biotechnol.
47
150-157
2006
Rosa sp.
-
Gong, L.; Jiang, C.; Zhang, B.; Hu, H.; Wang, W.; Liu, X.
Adenovirus-mediated expression of both antisense ornithine decarboxylase and S-adenosylmethionine decarboxylase induces G1 arrest in HT-29 cells
J. Biochem. Mol. Biol.
39
730-736
2006
Homo sapiens
Brooks, W.H.; McCloskey, D.E.; Daniel, K.G.; Ealick, S.E.; Secrist, J.A.; Waud, W.R.; Pegg, A.E.; Guida, W.C.
In silico chemical library screening and experimental validation of a novel 9-aminoacridine based lead-inhibitor of human S-adenosylmethionine decarboxylase
J. Chem. Inf. Model.
47
1897-1905
2007
Homo sapiens (P17707), Homo sapiens
Schaefer, B.; Hauber, I.; Bunk, A.; Heukeshoven, J.; Duesedau, A.; Bevec, D.; Hauber, J.
Inhibition of multidrug-resistant HIV-1 by interference with cellular S-adenosylmethionine decarboxylase activity
J. Infect. Dis.
194
740-750
2006
Human immunodeficiency virus 1
Tassoni, A.; Franceschetti, M.; Tasco, G.; Casadio, R.; Bagni, N.
Cloning, functional identification and structural modelling of Vitis vinifera S-adenosylmethionine decarboxylase
J. Plant Physiol.
164
1208-1219
2007
Vitis vinifera (Q7XZQ9), Vitis vinifera
Wi, S.J.; Kim, W.T.; Park, K.Y.
Overexpression of carnation S-adenosylmethionine decarboxylase gene generates a broad-spectrum tolerance to abiotic stresses in transgenic tobacco plants
Plant Cell Rep.
25
1111-1121
2006
Dianthus caryophyllus
Willert, E.K.; Fitzpatrick, R.; Phillips, M.A.
Allosteric regulation of an essential trypanosome polyamine biosynthetic enzyme by a catalytically dead homolog
Proc. Natl. Acad. Sci. USA
104
8275-8280
2007
Trypanosoma brucei (A5HNV7), Trypanosoma brucei
Burritt, D.J.
The polycyclic aromatic hydrocarbon phenanthrene causes oxidative stress and alters polyamine metabolism in the aquatic liverwort Riccia fluitans L
Plant Cell Environ.
31
1416-1431
2008
Riccia fluitans
van Brummelen, A.C.; Olszewski, K.L.; Wilinski, D.; Llinas, M.; Louw, A.I.; Birkholtz, L.M.
Co-inhibition of Plasmodium falciparum S-adenosylmethionine decarboxylase/ornithine decarboxylase reveals perturbation-specific compensatory mechanisms by transcriptome, proteome and metabolome analyses
J. Biol. Chem.
284
4635-4646
2008
Plasmodium falciparum
Kim, J.H.; Kim, H.S.; Lee, Y.H.; Kim, Y.S.; Oh, H.W.; Joung, H.; Chae, S.K.; Suh, K.H.; Jeon, J.H.
Polyamine biosynthesis regulated by StARD expression plays an important role in potato wound periderm formation
Plant Cell Physiol.
49
1627-1632
2008
Solanum tuberosum
Bale, S.; Baba, K.; McCloskey, D.E.; Pegg, A.E.; Ealick, S.E.
Complexes of Thermotoga maritima S-adenosylmethionine decarboxylase provide insights into substrate specificity
Acta Crystallogr. Sect. D
66
181-189
2010
Thermotoga maritima (Q9WZC3), Thermotoga maritima
Shiokawa, K.; Aso, M.; Kondo, T.; Takai, J.; Yoshida, J.; Mishina, T.; Fuchimukai, K.; Ogasawara, T.; Kariya, T.; Tashiro, K.; Igarashi, K.
Effects of S-adenosylmethionine decarboxylase, polyamines, amino acids, and weak bases (amines and ammonia) on development and ribosomal RNA synthesis in Xenopus embryos
Amino Acids
38
439-449
2010
Xenopus laevis
Bale, S.; Ealick, S.E.
Structural biology of S-adenosylmethionine decarboxylase
Amino Acids
38
451-460
2010
Trypanosoma brucei, Aquifex aeolicus (O66615), Aquifex aeolicus, Homo sapiens (P17707), Homo sapiens, Solanum tuberosum (Q04694), Solanum tuberosum, Thermotoga maritima (Q9WZC3), Thermotoga maritima
Blavid, R.; Kusch, P.; Hauber, J.; Eschweiler, U.; Sarite, S.R.; Specht, S.; Deininger, S.; Hoerauf, A.; Kaiser, A.
Down-regulation of hypusine biosynthesis in plasmodium by inhibition of S-adenosyl-methionine-decarboxylase
Amino Acids
38
461-469
2010
Plasmodium falciparum, Plasmodium falciparum NF54
Barker, R.H.; Liu, H.; Hirth, B.; Celatka, C.A.; Fitzpatrick, R.; Xiang, Y.; Willert, E.K.; Phillips, M.A.; Kaiser, M.; Bacchi, C.J.; Rodriguez, A.; Yarlett, N.; Klinger, J.D.; Sybertz, E.
Novel S-adenosylmethionine decarboxylase inhibitors for the treatment of human African trypanosomiasis
Antimicrob. Agents Chemother.
53
2052-2058
2009
Homo sapiens, Trypanosoma brucei
Bacchi, C.J.; Barker, R.H.; Rodriguez, A.; Hirth, B.; Rattendi, D.; Yarlett, N.; Hendrick, C.L.; Sybertz, E.
Trypanocidal activity of 8-methyl-5-[[(Z)-4-aminobut-2-enyl]-(methylamino)]adenosine (Genz-644131), an adenosylmethionine decarboxylase inhibitor
Antimicrob. Agents Chemother.
53
3269-3272
2009
Trypanosoma brucei brucei, Trypanosoma brucei rhodesiense, Trypanosoma brucei brucei Lab 110 EATRO
Hyvoenen, M.T.; Howard, M.T.; Anderson, C.B.; Grigorenko, N.; Khomutov, A.R.; Vepsaelaeinen, J.; Alhonen, L.; Jaenne, J.; Keinaenen, T.A.
Divergent regulation of the key enzymes of polyamine metabolism by chiral alpha-methylated polyamine analogues
Biochem. J.
422
321-328
2009
Homo sapiens
Bale, S.; Brooks, W.; Hanes, J.W.; Mahesan, A.M.; Guida, W.C.; Ealick, S.E.
Role of the sulfonium center in determining the ligand specificity of human S-adenosylmethionine decarboxylase
Biochemistry
48
6423-6430
2009
Homo sapiens (P17707), Homo sapiens
Hirth, B.; Barker, R.H.; Celatka, C.A.; Klinger, J.D.; Liu, H.; Nare, B.; Nijjar, A.; Phillips, M.A.; Sybertz, E.; Willert, E.K.; Xiang, Y.
Discovery of new S-adenosylmethionine decarboxylase inhibitors for the treatment of Human African Trypanosomiasis (HAT)
Bioorg. Med. Chem. Lett.
19
2916-2919
2009
Trypanosoma brucei
Pegg, A.E.
S-Adenosylmethionine decarboxylase
Essays Biochem.
46
25-45
2009
Bacillus subtilis, Saccharomyces cerevisiae, Catharanthus roseus, Clostridium acetobutylicum, Escherichia coli, Homo sapiens, Methanocaldococcus jannaschii, Solanum tuberosum, Thermotoga maritima, Trypanosoma brucei, Trypanosoma cruzi
Xiao, Y.; McCloskey, D.E.; Phillips, M.A.
RNA interference-mediated silencing of ornithine decarboxylase and spermidine synthase genes in Trypanosoma brucei provides insight into regulation of polyamine biosynthesis
Eukaryot. Cell
8
747-755
2009
Trypanosoma brucei
Kielosto, M.; Nummela, P.; Jaervinen, K.; Yin, M.; Hoelttae, E.
Identification of integrins alpha6 and beta7 as c-Jun- and transformation-relevant genes in highly invasive fibrosarcoma cells
Int. J. Cancer
125
1065-1073
2009
Mus musculus
Lee, J.; Sperandio, V.; Frantz, D.E.; Longgood, J.; Camilli, A.; Phillips, M.A.; Michael, A.J.
An alternative polyamine biosynthetic pathway is widespread in bacteria and essential for biofilm formation in Vibrio cholerae
J. Biol. Chem.
284
9899-9907
2009
no activity in Vibrio cholerae
Cheng, L.; Zou, Y.; Ding, S.; Zhang, J.; Yu, X.; Cao, J.; Lu, G.
Polyamine accumulation in transgenic tomato enhances the tolerance to high temperature stress
J. Integr. Plant Biol.
51
489-499
2009
Saccharomyces cerevisiae
McCloskey, D.E.; Bale, S.; Secrist, J.A.; Tiwari, A.; Moss, T.H.; Valiyaveettil, J.; Brooks, W.H.; Guida, W.C.; Pegg, A.E.; Ealick, S.E.
New insights into the design of inhibitors of human S-adenosylmethionine decarboxylase: Studies of adenine C8 substitution in structural analogues of S-adenosylmethionine
J. Med. Chem.
52
1388-1407
2009
Homo sapiens (P17707), Homo sapiens
Paschalidis, K.A.; Moschou, P.N.; Toumi, I.; Roubelakis-Angelakis, K.A.
Polyamine anabolic/catabolic regulation along the woody grapevine plant axis
J. Plant Physiol.
166
1508-1519
2009
Vitis vinifera
Huang, X.; Bie, Z.
Cinnamic acid-inhibited ribulose-1,5-bisphosphate carboxylase activity is mediated through decreased spermine and changes in the ratio of polyamines in cowpea
J. Plant Physiol.
167
47-53
2010
Vigna unguiculata
Koomoa, D.L.; Borsics, T.; Feith, D.J.; Coleman, C.C.; Wallick, C.J.; Gamper, I.; Pegg, A.E.; Bachmann, A.S.
Inhibition of S-adenosylmethionine decarboxylase by inhibitor SAM486A connects polyamine metabolism with p53-Mdm2-Akt/protein kinase B regulation and apoptosis in neuroblastoma
Mol. Cancer Ther.
8
2067-2075
2009
Homo sapiens
Hassan, M.; Oldach, K.; Baumann, U.; Langridge, P.; Sutton, T.
Genes mapping to boron tolerance QTL in barley identified by suppression subtractive hybridization
Plant Cell Environ.
33
188-198
2010
Hordeum vulgare
Peremarti, A.; Bassie, L.; Christou, P.; Capell, T.
Spermine facilitates recovery from drought but does not confer drought tolerance in transgenic rice plants expressing Datura stramonium S-adenosylmethionine decarboxylase
Plant Mol. Biol.
70
253-264
2009
Oryza sativa Japonica Group (Q0JC10), Datura stramonium (Q96555), Datura stramonium
Peremarti, A.; Bassie, L.; Yuan, D.; Pelacho, A.; Christou, P.; Capell, T.
Transcriptional regulation of the rice arginine decarboxylase (Adc1) and S-adenosylmethionine decarboxylase (Samdc) genes by methyl jasmonate
Plant Physiol. Biochem.
48
553-559
2010
Datura stramonium
Falasca, G.; Franceschetti, M.; Bagni, N.; Altamura, M.M.; Biasi, R.
Polyamine biosynthesis and control of the development of functional pollen in kiwifruit
Plant Physiol. Biochem.
48
565-573
2010
Actinidia deliciosa
Wada, M.; Shirahata, A.
Conformational stabilization of rat S-adenosylmethionine decarboxylase by putrescine
Biol. Pharm. Bull.
33
1800-1805
2010
Rattus norvegicus
Wada, M.; Shirahata, A.
Identification of the primary structure and post-translational modification of rat S-adenosylmethionine decarboxylase
Biol. Pharm. Bull.
33
891-894
2010
Rattus norvegicus
Paasinen-Sohns, A.; Kaeaeriaeinen, E.; Yin, M.; Jaervinen, K.; Nummela, P.; Hoelttae, E.
Chaotic neovascularization induced by aggressive fibrosarcoma cells overexpressing S-adenosylmethionine decarboxylase
Int. J. Biochem. Cell Biol.
43
441-454
2011
Homo sapiens
Wang, J.; Liu, J.; Kurosawa, T.; Nada, K.; Ban, Y.; Moriguchi, T.
Cloning, biochemical identification, and expression analysis of a gene encoding S-adenosylmethionine decarboxylase in navel orange (Citrus sinensis Osbeck)
J. Hortic. Sci. Biotechnol.
85
219-226
2010
Citrus sinensis
-
Williams, M.; Sprenger, J.; Human, E.; Al-Karadaghi, S.; Persson, L.; Louw, A.I.; Birkholtz, L.M.
Biochemical characterisation and novel classification of monofunctional S-adenosylmethionine decarboxylase of Plasmodium falciparum
Mol. Biochem. Parasitol.
180
17-26
2011
Plasmodium falciparum
Gomez-Jimenez, M.C.; Paredes, M.A.; Gallardo, M.; Fernandez-Garcia, N.; Olmos, E.; Sanchez-Calle, I.M.
Tissue-specific expression of olive S-adenosyl methionine decarboxylase and spermidine synthase genes and polyamine metabolism during flower opening and early fruit development
Planta
232
629-647
2010
Olea europaea (D2K8S5)
Giles, T.N.; Graham, D.E.
Crenarchaeal arginine decarboxylase evolved from an S-adenosylmethionine decarboxylase enzyme
J. Biol. Chem.
283
25829-25838
2008
Saccharolobus solfataricus (Q9UWY8), Saccharolobus solfataricus, Saccharolobus solfataricus P2 (Q9UWY8)
Lasanajak, Y.; Minocha, R.; Minocha, S.C.; Goyal, R.; Fatima, T.; Handa, A.K.; Mattoo, A.K.
Enhanced flux of substrates into polyamine biosynthesis but not ethylene in tomato fruit engineered with yeast S-adenosylmethionine decarboxylase gene
Amino Acids
46
729-742
2014
Saccharomyces cerevisiae
Velez, N.; Brautigam, C.A.; Phillips, M.A.
Trypanosoma brucei S-adenosylmethionine decarboxylase N terminus is essential for allosteric activation by the regulatory subunit prozyme
J. Biol. Chem.
288
5232-5240
2013
Trypanosoma brucei
Xiao, Y.; Nguyen, S.; Kim, S.H.; Volkov, O.A.; Tu, B.P.; Phillips, M.A.
Product feedback regulation implicated in translational control of the Trypanosoma brucei S-adenosylmethionine decarboxylase regulatory subunit prozyme
Mol. Microbiol.
88
846-861
2013
Trypanosoma brucei
Singh, S.P.; Agnihotri, P.; Pratap, J.V.
Characterization of a novel putative S-adenosylmethionine decarboxylase-like protein from Leishmania donovani
PLoS ONE
8
e65912
2013
Leishmania donovani (Q25264), Leishmania donovani
Feng, J.; Wu, J.; Dai, N.; Lin, S.; Xu, H.H.; Deng, Z.; He, X.
Discovery and characterization of BlsE, a radical S-adenosyl-L-methionine decarboxylase involved in the blasticidin S biosynthetic pathway
PLoS ONE
8
e68545
2013
Streptomyces griseochromogenes (Q841K9)
Mishra, A.K.; Agnihotri, P.; Srivastava, V.K.; Pratap, J.V.
Novel protein-protein interaction between spermidine synthase and S-adenosylmethionine decarboxylase from Leishmania donovani
Biochem. Biophys. Res. Commun.
456
637-642
2015
Leishmania donovani
Volkov, O.A.; Brockway, A.J.; Wring, S.A.; Peel, M.; Chen, Z.; Phillips, M.A.; De Brabander, J.K.
Species-selective pyrimidineamine inhibitors of Trypanosoma brucei S-adenosylmethionine decarboxylase
J. Med. Chem.
61
1182-1203
2018
Trypanosoma brucei brucei (Q587A7), Trypanosoma brucei brucei 927/4 GUTat10.1 (Q587A7)
Wi, S.; Kim, S.; Kim, W.; Park, K.
Constitutive S-adenosylmethionine decarboxylase gene expression increases drought tolerance through inhibition of reactive oxygen species accumulation in Arabidopsis
Planta
239
979-988
2014
Capsicum annuum (K7R0T7), Capsicum annuum
Mo, H.J.; Sun, Y.X.; Zhu, X.L.; Wang, X.F.; Zhang, Y.; Yang, J.; Yan, G.J.; Ma, Z.Y.
Cotton S-adenosylmethionine decarboxylase-mediated spermine biosynthesis is required for salicylic acid- and leucine-correlated signaling in the defense response to Verticillium dahliae
Planta
243
1023-1039
2016
Gossypium hirsutum (F8V332), Gossypium hirsutum
Makhoba, X.; Burger, A.; Coertzen, D.; Zininga, T.; Birkholtz, L.; Shonhai, A.
Use of a chimeric Hsp70 to enhance the quality of recombinant Plasmodium falciparum S-adenosylmethionine decarboxylase protein produced in Escherichia coli
PLoS ONE
11
e0152626
2016
Plasmodium falciparum (A0A1D3TG90), Plasmodium falciparum
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