4.1.1.50: adenosylmethionine decarboxylase

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For detailed information about adenosylmethionine decarboxylase, go to the full flat file.

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Synonyms

Ado-MetDC, AdoMet decarboxylase, AdoMetDC, AdoMetDC/ODC, AMDC, BjSAMDC1, BjSAMDC2, BjSAMDC3, BjSAMDC4, BlsE, Bud2, MdSAMDC1, MdSAMDC2, OsSAMDC, PfAdoMetDC, protein SSO0585, S-adenosyl methionine decarboxylase, S-Adenosyl-L-methionine decarboxylase, S-adenosyl-methionine-decarboxylase, S-adenosylmethionine decarboxy-lase/ornithine decarboxylase, S-Adenosylmethionine decarboxylase, S-adenosylmethionine decarboxylase 1, S-adenosylmethionine decarboxylase 2, S-adenosylmethionine decarboxylase 3, S-adenosylmethionine decarboxylase 4, SAM decarboxylase, SAM-DC, SAMDC, SvPEPC, Tb927.6.4410

ECTree

     4 Lyases

         4.1 Carbon-carbon lyases

             4.1.1 Carboxy-lyases

                4.1.1.50 adenosylmethionine decarboxylase

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Results	in table
89	Activating Compound
15978	AA Sequence
12	Application
1	CAS Registry Number
37	Cloned(Commentary)
42	Cofactor
13	Crystallization (Commentary)
588	Disease/ Diagnostics
22	Expression
12	General Information
2	General Stability
35	IC50 Value
396	Inhibitors
9	kcat/KM [mM/s]
8	Ki Value [mM]
46	KM Value [mM]
3	Localization
43	Metals/Ions
74	Molecular Weight [Da]
38	Natural Substrates/ Products (Substrates)
170	Organism
8	Pathway
93	PDB ID
15	pH Optimum
3	pH Range
3	pH Stability
16	Posttranslational Modification
50	Protein Variants
41	Purification (Commentary)
5	Reaction
2	Reaction Type
167	Reference
1	Renatured (Commentary)
104	Source Tissue
35	Specific Activity [micromol/min/mg]
11	Storage Stability
148	Substrates and Products (Substrate)
58	Subunits
157	Synonyms
1	Systematic Name
5	Temperature Optimum [°C]
1	Temperature Range [°C]
10	Temperature Stability [°C]
15	Turnover Number [1/s]

Application

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Application on EC 4.1.1.50 - adenosylmethionine decarboxylase

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APPLICATION

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

agriculture

Rosa sp.

-

incubation of the cut flower with water increases both enzyme activity and spermine content 2fold, which are followed by ethylene production. Reaction may be a resistance mechanism against fungal and bacterial infection. Overexpression of enzyme may be a tool to improve rose cultivars for the common usage

680076

analysis

Homo sapiens

-

development of a simple, economic, and non-radioactive spectrometric enzymatic assay, which can be adapted for experimental high-throughput screening of AdoMetDC inhibitors

749303

biotechnology

Datura stramonium

Q96555

overexpression of enzyme is sufficient for accumulation of spermidine in leaves and spermidine and spermine in seeds

653529

medicine

4 entries

pharmacology

4 entries

synthesis

Plasmodium falciparum

A0A1D3TG90

coexpression of S-adenosylmethionine decarboxylase with chimeric protein KPf, which is made up of the ATPase domain of Escherichia coli DnaK and the substrate binding domain of Plasmodium falciparum Hsp70, and DnaK in Escherichia coli cells. The recombinant protein exhibits improved activity compared to protein coexpressed with overexpressed DnaK

749083

medicine

Mus musculus

-

essential role of enzyme in embryonic development, polyamines are required for cell proliferation after E3.5

651416

medicine

Homo sapiens

-

S-adenosyl methionine decarboxylase activity is required for the outcome of herpes simplex virus type 1 infection and represents a new potential therapeutic target, inhibition of the enzyme by methylglyoxal bis(guanylhydrazone) prevents HSV-1 infection

664878

medicine

Homo sapiens

-

adenovirus-mediated expression of both antisense ornithine decarboxylase and S-adenosylmethionine decarboxylase in lung cancer cell line A-549. Antisense enzyme expression inhibits tumor cell growth through blocking the polyamine synthesis pathway. Tumor cells are arrested at G1 phase and invasivness is reduced

677292

medicine

Human immunodeficiency virus 1

-

enzyme inhibitor (2E)-2-[4-[amino(imino)methyl]-2,3-dihydro-1H-inden-1-ylidene]hydrazinecarboximidamide, i.e. CGP48664A, SAM486A, suppresses HIV-1 replication, including the replication of viruses that are resistant to multiple reverse transcriptase and protease inhibitos. Antiretroviral effect is based on the fact that regulatory protein Rev activity is severely compromised in drug-treated cells. No toxic effects on cellular metabolism are observed

681225

pharmacology

Mus musculus

-

the enzyme is a target for cancer chemotherapy

4665

pharmacology

Caenorhabditis elegans

O02655

potentially important drug target for the chemotherapy of proliferative and parasitic diseases

4685

pharmacology

Onchocerca volvulus

-

potentially important target for chemotherapy of filiarial infection

4687

pharmacology

Mus musculus

-

potential target for therapeutic agents against various parasitic diseases and proliferating disorders

4699