Information on EC 4.1.1.50 - adenosylmethionine decarboxylase

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The enzyme appears in viruses and cellular organisms

EC NUMBER
COMMENTARY hide
4.1.1.50
-
RECOMMENDED NAME
GeneOntology No.
adenosylmethionine decarboxylase
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
S-adenosyl-L-methionine = S-adenosyl 3-(methylthio)propylamine + CO2
show the reaction diagram
REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
decarboxylation
PATHWAY
BRENDA Link
KEGG Link
MetaCyc Link
Arginine and proline metabolism
-
-
Cysteine and methionine metabolism
-
-
Metabolic pathways
-
-
polyamine pathway
-
-
spermidine biosynthesis I
-
-
spermidine biosynthesis III
-
-
spermine biosynthesis
-
-
SYSTEMATIC NAME
IUBMB Comments
S-adenosyl-L-methionine carboxy-lyase [(5-deoxy-5-adenosyl)(3-aminopropyl)methylsulfonium-salt-forming]
The Escherichia coli enzyme contains a pyruvoyl group.
CAS REGISTRY NUMBER
COMMENTARY hide
9036-20-8
-
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
Neff strain
-
-
Manually annotated by BRENDA team
Neff strain
-
-
Manually annotated by BRENDA team
variant deliciosa
-
-
Manually annotated by BRENDA team
-
Uniprot
Manually annotated by BRENDA team
-
-
-
Manually annotated by BRENDA team
calf
-
-
Manually annotated by BRENDA team
cultivar Newhall
-
-
Manually annotated by BRENDA team
increase in enzyme activity during exponential growth
-
-
Manually annotated by BRENDA team
strain HT527
-
-
Manually annotated by BRENDA team
-
-
-
Manually annotated by BRENDA team
cultivars Sahara and Clipper
-
-
Manually annotated by BRENDA team
-
UniProt
Manually annotated by BRENDA team
Mill. var. domestica (Borkh.) Mansf.
SwissProt
Manually annotated by BRENDA team
-
-
-
Manually annotated by BRENDA team
no activity in Vibrio cholerae
-
-
-
Manually annotated by BRENDA team
proenzyme; cultivars Arbequina and Picual
UniProt
Manually annotated by BRENDA team
S-adenosylmethionine decarboxylase proenzyme; cold-tolerant japonica cultivar Yukihikari and cold-susceptible indica variety TKM9
-
-
Manually annotated by BRENDA team
strain NF54
-
-
Manually annotated by BRENDA team
-
-
-
Manually annotated by BRENDA team
-
-
-
Manually annotated by BRENDA team
recombinant enzyme, expression in Escherichia coli
-
-
Manually annotated by BRENDA team
strain Lab 110 EATRO
-
-
Manually annotated by BRENDA team
Trypanosoma brucei brucei Lab 110 EATRO
strain Lab 110 EATRO
-
-
Manually annotated by BRENDA team
strains KETRI 243 and 2538
-
-
Manually annotated by BRENDA team
cultivar jiagongno.7
-
-
Manually annotated by BRENDA team
-
-
-
Manually annotated by BRENDA team
-
-
-
Manually annotated by BRENDA team
GENERAL INFORMATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
malfunction
-
overexpression of S-adenosylmethionine decarboxylase in rodent fibroblasts leads to aggressive transformants (Amdc-s cells) that have high invasive capacity in nude mice, invading rapidly from the subcutaneous injection site into the peritoneal cavity and its organs. Amdc-s-induced tumors show chaotic neovascularization, with abundant pleomorphic vessel-like structures that have noncontiguous or totally missing laminin (basement membrane) and CD31 (endothelial cell) immunoreactivity
metabolism
physiological function
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
(5-deoxy-5-adenosyl)(3-aminopropyl)-methylsulfonium + CO2
S-adenosyl-L-methionine + H+
show the reaction diagram
-
-
-
-
?
Adenosylethionine
?
show the reaction diagram
-
poor substrate
-
-
-
S-adenosyl-L-methionine
(5-deoxy-5-adenosyl)(3-aminopropyl)-methylsulfonium salt + CO2
show the reaction diagram
S-adenosyl-L-methionine
(5-deoxy-5-adenosyl)(3-aminopropyl)methylsulfonium salt + CO2
show the reaction diagram
S-adenosyl-L-methionine
?
show the reaction diagram
S-adenosyl-L-methionine
S-adenosyl 3-(methylthio)propylamine + CO2
show the reaction diagram
additional information
?
-
NATURAL SUBSTRATES
NATURAL PRODUCTS
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
S-adenosyl-L-methionine
(5-deoxy-5-adenosyl)(3-aminopropyl)methylsulfonium salt + CO2
show the reaction diagram
S-adenosyl-L-methionine
?
show the reaction diagram
S-adenosyl-L-methionine
S-adenosyl 3-(methylthio)propylamine + CO2
show the reaction diagram
additional information
?
-
COFACTOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
pyridoxal 5'-phosphate
thiamine diphosphate
[4Fe-4S]-center
the fully reconstituted His6-tagged enzyme contains approximately 6.8 iron equivalents per monomer
METALS and IONS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
Al3+
-
activation, no significant influence on the rate-limiting step. Km value 0.850 mM
Co2+
-
activation, no significant influence on the rate-limiting step. Km value 0.286 mM
Eu3+
-
activation, no significant influence on the rate-limiting step. Km value 0.095 mM
Fe2+
-
activation, no significant influence on the rate-limiting step. Km value 0.121 mM
Fe3+
-
activation, no significant influence on the rate-limiting step. Km value 0.194 mM
Gd3+
-
activation, no significant influence on the rate-limiting step. Km value 0.043 mM
Li+
-
activation, no significant influence on the rate-limiting step. Km value 0.219 mM
Tb3+
-
activation, no significant influence on the rate-limiting step. Km value 0.151 mM
additional information
INHIBITORS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
(1E)-1-(9-bromo-3-phenanthryl)ethanone oxime
-
75% inhibition at 0.1 mM
(2E)-2-[(2E)-2-[(diaminomethyl)hydrazono]-1-methylethylidene]hydrazinecarboximidamide
-
i.e. MGBG, active site inhibitor
(2E)-2-[4-[amino(imino)methyl]-2,3-dihydro-1H-inden-1-ylidene]hydrazinecarboximidamide
(2R,3R,4R,5R)-2-([[(2Z)-4-aminobut-2-en-1-yl](methyl)amino]methyl)-5-(6-amino-9H-purin-9-yl)-4-fluorotetrahydrofuran-3-ol
-
-
(2R,3R,4S,5R)-2-([[(2Z)-4-aminobut-2-en-1-yl](methyl)amino]methyl)-5-(6-amino-9H-purin-9-yl)-4-fluorotetrahydrofuran-3-ol
-
-
(2R,3S,4R,5R)-2-([[(2Z)-4-aminobut-2-en-1-yl](methyl)amino]methyl)-5-(6-amino-2-chloro-9H-purin-9-yl)tetrahydrofuran-3,4-diol
-
-
(5-deoxy-5-adenosyl)(3-aminopropyl)methylsulfonium salt
(R)-alpha-methylspermine
-
-
(R,R)-alpha,omega-bismethylspermine
-
best suppressor of AdoMetDC activity
(S)-(5'-deoxy-5'-adenosyl)methylthioethylhydroxylamine
(S)-alpha-methylspermidine
-
-
1,1'-[(Methylethanediylidene)dinitrilo] bis(3-aminoguanidine)
-
-
1,3-di-9H-fluoren-2-ylthiourea
-
69% inhibition at 0.1 mM
1-(4-hydroxy-5-isopropyl-2-methylphenyl)-3-(1-naphthyl)urea
-
61% inhibition at 0.1 mM
2'-Chlorodeoxyadenosine
-
-
2'-[(9H-fluoren-2-ylamino)carbonyl]biphenyl-2-carboxylate
-
74% inhibition at 0.1 mM
2,2'-Dihydroxy-6,6'-dinaphthyl disulfide
-
-
2,2'-dipyridyl
-
-
2-[2-(diethylammonio)ethyl]-9-hydroxy-5,11-dimethyl-6H-pyrido[4,3-b]carbazol-2-ium
-
67% inhibition at 0.1 mM
3-[(E)-[(2E)-[amino[(2E)-2-[3-[amino(imino)methyl]benzylidene]hydrazino]methylene]hydrazono]methyl]benzenecarboximidamide
-
i.e. CGP40215, active site inhibitor
4-Amidinoindan-1-(2'-amidino)hydrazone
4-amidinoindan-1-one-2'-amidinohydrazone
4-Bromo-3-hydroxybenzoyloxyamine dihydrogen phosphate
-
i.e. NSD-1055
4-Bromo-3-hydroxybenzyloxyamine
-
-
4-[(E)-2-(2-chlorophenyl)vinyl]quinolinium
-
67% inhibition at 0.1 mM
5'-([(Z)-4-Amino-2-butenyl]methylamino)-5'-deoxyadenosine
-
i.e. MDL 73811
5'-deoxy 5'-[(2-guanidinoethyl)methylamino]adenosine
less than 5% inhibition at 0.1 mM
5'-deoxy-5'-(2-methylaminoethylamino)adenosine
less than 5% inhibition at 0.1 mM
5'-deoxy-5'-(3-methylaminopropylamino)-8-phenyladenosine sulfate
less than 5% inhibition at 0.1 mM
5'-deoxy-5'-(dimethyl-sulfonio)adenosine
5'-deoxy-5'-(N,N-dimethylamino)-8-methyladenosine
-
5'-deoxy-5'-(N,N-dimethylamino)adenosine
-
5'-deoxy-5'-(N-dimethyl)amino-8-methyl adenosine
5'-deoxy-5'-(N-dimethyl)amino-8-methyladenosine
-
-
5'-deoxy-5'-dimethylsulfonio-8-methyladenosine
5'-deoxy-5'-dimethylsulfonio-8-methyladenosine chloride
-
5'-deoxy-5'-dimethylsulfonioadenosine chloride
-
5'-deoxy-5'-dimethylthioadenosine
-
-
5'-deoxy-5'-[(2-aminooxyethyl)methylamino]adenosine
5'-deoxy-5'-[(2-hydrazinocarbonylethyl)methylamino]-8-methyladenosine sulfate
-
5'-deoxy-5'-[(2-hydrazinocarbonylethyl)methylamino]-adenosine sulfate
-
5'-deoxy-5'-[(2-hydrazinoethyl)methylamino]adenosine
-
5'-deoxy-5'-[(2-hydroxyamidinoethyl)methylamino]adenosine
-
5'-Deoxy-5'-[(3-hydrazinopropyl)methylamino]adenosine
5'-deoxy-5'-[(hydrazinocarbonylmethyl)methylamino]-8-methyladenosine
-
5'-deoxy-5'-[N-methyl-N-(3-hydrazino-propyl)amino]adenosine
5'-deoxy-5'-[N-methyl-N-(3-hydrazinopropyl)amino]adenosine
-
-
5'-deoxy-5'-[N-methyl-N-[(2-aminooxy)-ethyl]amino]adenosine
5'-deoxy-5'-[N-methyl-N-[(2-aminooxy)ethyl]amino]adenosine
-
-
5'-deoxy-8-(methylamino)-5'-(3-methylaminopropylamino)adenosine sulfate
less than 5% inhibition at 0.1 mM
5'-deoxy-8-methyl-5'-(2-methylaminoethylamino)adenosine
less than 5% inhibition at 0.1 mM
5'-dimethylthioadenosine sulfonium salt
-
-
5'-methylthioadenosine
-
-
5'-[(2-aminoethyl)methylamino]-5'-deoxy-8-methyladenosine
-
5'-[(2-aminoethyl)methylamino]-5'-deoxyadenosine
less than 5% inhibition at 0.1 mM
5'-[(2-aminooxyethyl)methylamino]-5'-deoxy-8-(methylamino)adenosine sulfate
-
5'-[(2-aminooxyethyl)methylamino]-5'-deoxy-8-methyladenosine sulfate
-
5'-[(2-aminooxyethyl)methylamino]-5'-deoxy-8-phenyladenosine sulfate
less than 5% inhibition at 0.1 mM
5'-[(2-aminooxyethyl)methylamino]-5'-deoxyadenosine
-
5'-[(2-carboxamidoethyl)methyamino]-5'-deoxy-8-ethyladenosine sulfate
-
5'-[(2-carboxamidoethyl)methylamino]-5'-deoxy-8-methyladenosine sulfate
-
5'-[(2-carboxamidoethyl)methylamino]-5'-deoxyadenosine sulfate
-
5'-[(3-aminopropyl)methylamino]-5'-deoxy-8-(methylamino)adenosine sulfate
-
5'-[(3-aminopropyl)methylamino]-5'-deoxy-8-ethyladenosine sulfate
-
5'-[(3-aminopropyl)methylamino]-5'-deoxy-8-methyladenosine sulfate
-
5'-[(3-aminopropyl)methylamino]-5'-deoxy-8-phenyladenosine sulfate
less than 5% inhibition at 0.1 mM
5'-[(3-aminopropyl)methylamino]-5'-deoxyadenosine sulfate
-
5'-[(4-aminooxybutyl)methylamino]-5'-deoxy-8-(methylamino)adenosine sulfate
-
5'-[(4-aminooxybutyl)methylamino]-5'-deoxy-8-ethyladenosine sulfate
-
5'-[(4-aminooxybutyl)methylamino]-5'-deoxy-8-methyladenosine sulfate
-
5'-[(4-aminooxybutyl)methylamino]-5'-deoxy-8-oxoadenosine sulfate
-
5'-[(4-aminooxybutyl)methylamino]-5'-deoxy-8-phenyladenosine sulfate
less than 5% inhibition at 0.1 mM
5'-[(4-aminooxybutyl)methylamino]-5'-deoxyadenosine sulfate
-
5'-[(carboxamidomethyl)methylamino]-5'-deoxy-8-methyladenosine sulfate
less than 5% inhibition at 0.1 mM
5'-[[(2Z)-4-aminobut-2-en-1-yl](methyl)amino]-5'-deoxy-2-methyladenosine
-
-
5'-[[(2Z)-4-aminobut-2-en-1-yl](methyl)amino]-5'-deoxy-8-ethyladenosine
-
-
5'-[[(2Z)-4-aminobut-2-en-1-yl](methyl)amino]-5'-deoxy-8-methyladenosine
-
-
5'-[[(2Z)-4-aminobut-2-en-1-yl](methyl)amino]-5'-deoxy-8-propyladenosine
-
-
5'-[[(Z)-4-amino-2-butenyl]methylamino]-5'-deoxyadenosine
5'-[[(Z)-4-aminobut-2-enyl](methylamino)]adenosine
5'-{[(Z)-4-Amino-2-butenyl]methylamino}-5'-deoxyadenosine
5,5'-dithiobis(2-nitrobenzoate)
-
-
8-methyl-5'-[[(Z)-4-aminobut-2-enyl]-(methylamino)]adenosine
9-amino-6-[(E)-(2,6-diaminopyridin-3-yl)diazenyl]-2-ethoxyacridinium
-
64% inhibition at 0.1 mM
9-hydroxy-5,11-dimethyl-2-(2-piperidinium-1-ylethyl)-6H-pyrido[4,3-b]carbazol-2-ium
-
69% inhibition at 0.1 mM
agmatine
-
-
aminoguanidine
-
irreversible
Berenil
Bis[[3-(aminoiminomethyl)phenyl]methylene]carbonimidic dihydrazide trihydrochloride
-
i.e. CGP 40215A
Canaline
-
at high concentrations
CGP 48664
-
specific inhibitor of AdoMetDC
CGP 48664A
-
i.e. 4-amidinoindan-1-one-20-amidinohydrazone, also known as SAM486A
CGP48664
-
non-competitive inhibition, i.e. 4-amidinoindan-1-one-2'-amidinohydrazone
CGP48664A
Di-N'''-Methylglyoxal bis(guanylhydrazone)
-
-
Di-N''-Methylglyoxal bis(guanylhydrazone)
-
-
Dimethylglyoxal bis(guanylhydrazone)
-
-
Ethambutol
-
14% inhibition at 1 mM
Ethidium bromide
-
-
ethylglyoxal bis(guanylhydrazone)
FeCl2
-
0.5 mM
Genz-643990
Genz-644043
Genz-644053
Genz-644131
Glyoxal bis(guanylhydrazone)
-
-
hydroxylamine
-
-
Hydroxystilbamidine
-
-
iodoacetamide
-
-
iodoacetic acid
Isonicotinic acid hydrazide
-
at high concentrations
MDL 27695
MDL 73811
-
-
MDL 73822
-
irreversibel
-
MDL73811
methylglyoxal bis(guanylhydrazone)
methylglyoxal bis-(guanylhydrazone)
-
-
methylglyoxal-bis (guanylhydrazone)
methylglyoxal-bis(guanylhydrazone)
methylglyoxalbis(guanylhydrazone)
MgCl2
-
0.5 mM
MnCl2
-
0.5 mM
n-Butylglyoxal bis(guanylhydrazone)
-
-
NaCl
-
enzyme from infected cells is unaffected up to 0.8 M, 50% inhibition of the enzyme from uninfected cells at 0.45 M
NaCNBH3
NH4Cl
-
0.5 mM
p-chloromercuribenzoate
-
-
p-hydroxymercuribenzoate
-
-
p-Hydroxymercuriphenylsulfonate
-
-
Pentamidine
Pentane dialdehyde bis(guanylhydrazone)
phenylhydrazine
PMW-2000-11-13-1
Propamidine
-
-
Propane dialdehyde bis(guanylhydrazone)
putrescine
RHW-17-69-75
S-(5'-Adenosyl)-methylthio-2-aminooxyethane
-
potent irreversible inhibitor
S-(5'-Deoxy-5'-adenosyl)methylthioethylhydroxylamine
S-Adenosyl-4-methylthiobutyric acid
-
-
S-adenosyl-L-methionine
S-Methyl-S-adenosyl-L-cysteine
-
-
S-methyladenosylhomocysteamine
-
strong
Salicylaldehyde
-
inactivation, substrate protects
SAM486A
Semicarbazide
-
-
spermidine
spermine
additional information
ACTIVATING COMPOUND
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
(2E)-2-[4-[amino(imino)methyl]-2,3-dihydro-1H-inden-1-ylidene]hydrazinecarboximidamide
-
stimulation in the range of 0.1-10 microM, inhibition at higher comcentration
1,15-diamino-4,12-diazapentadecane
-
-
1,3-Diaminopropane
1,5-Diaminopentane
1,6-diaminohexane
-
58% of activation by putrescine
1,7-Diaminoheptane
-
45% of activation by putrescine
cadaverine
difluoromethylornithine
-
5 mM causes an induction of the enzyme activity
N1-acetylspermidine
-
60% of activation by putrescine
phenanthrene
-
concentrations of phenanthrene up to 0.5 microM cause significant increases in the activity of SAMDC, with a resultant increase in tissue polyamine levels
pi' subunit
PMW-2000-11-13-5
-
-
putrescine
pyruvate
spermidine
spermine
YZ-33-046
-
-
YZ-33-050C
-
-
additional information
KM VALUE [mM]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
1.518
lysine
-
-
0.00193 - 1
S-adenosyl-L-methionine
0.06 - 0.96
S-adenosylmethionine
additional information
additional information
TURNOVER NUMBER [1/s]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.0013 - 1.7
S-adenosyl-L-methionine
6
S-adenosyl-methionine
Trypanosoma cruzi
-
in presence of putrescine
additional information
additional information
Methanocaldococcus jannaschii
-
increase of turnover-number 38-fold at physiological temperature of 80C
-
kcat/KM VALUE [1/mMs-1]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
2.3 - 46000
S-adenosyl-L-methionine
Ki VALUE [mM]
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.003 - 0.00407
CGP48664
0.00033 - 0.0016
MDL73811
2 - 5
methylglyoxal bis(guanylhydrazone)
-
-
0.00015
methylglyoxal bis-(guanylhydrazone)
-
-
0.45
NaCl
-
enzyme from infected cells is unaffected up to 0.8 M; inhibition of the enzyme from uninfected cells
IC50 VALUE [mM]
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
1.2 - 104
3-[(E)-[(2E)-[amino[(2E)-2-[3-[amino(imino)methyl]benzylidene]hydrazino]methylene]hydrazono]methyl]benzenecarboximidamide
0.0006
5'-deoxy-5'-(N,N-dimethylamino)-8-methyladenosine
Homo sapiens
P17707
-
0.009
5'-deoxy-5'-(N,N-dimethylamino)adenosine
Homo sapiens
P17707
-
0.003
5'-deoxy-5'-dimethylsulfonio-8-methyladenosine chloride
Homo sapiens
P17707
-
0.015
5'-deoxy-5'-dimethylsulfonioadenosine chloride
Homo sapiens
P17707
-
0.00017
5'-deoxy-5'-[(2-hydrazinocarbonylethyl)methylamino]-8-methyladenosine
Homo sapiens
P17707
-
0.0015
5'-deoxy-5'-[(2-hydrazinocarbonylethyl)methylamino]-adenosine sulfate
Homo sapiens
P17707
-
0.157
5'-deoxy-5'-[(2-hydroxyamidinoethyl)methylamino]adenosine
Homo sapiens
P17707
-
0.031
5'-deoxy-5'-[(hydrazinocarbonylmethyl)methylamino]-8-methyladenosine
Homo sapiens
P17707
-
0.088
5'-[(2-aminoethyl)methylamino]-5'-deoxy-8-methyladenosine
Homo sapiens
P17707
-
0.000086
5'-[(2-aminooxyethyl)methylamino]-5'-deoxy-8-(methylamino)adenosine sulfate
Homo sapiens
P17707
-
0.000007
5'-[(2-aminooxyethyl)methylamino]-5'-deoxy-8-methyladenosine sulfate
Homo sapiens
P17707
-
0.000055
5'-[(2-aminooxyethyl)methylamino]-5'-deoxyadenosine
Homo sapiens
P17707
-
0.004
5'-[(2-carboxamidoethyl)methyamino]-5'-deoxy-8-ethyladenosine sulfate
Homo sapiens
P17707
-
0.0004
5'-[(2-carboxamidoethyl)methylamino]-5'-deoxy-8-methyladenosine sulfate
Homo sapiens
P17707
-
0.007
5'-[(2-carboxamidoethyl)methylamino]-5'-deoxyadenosine sulfate
Homo sapiens
P17707
-
0.44
5'-[(3-aminopropyl)methylamino]-5'-deoxy-8-(methylamino)adenosine sulfate
Homo sapiens
P17707
-
0.42
5'-[(3-aminopropyl)methylamino]-5'-deoxy-8-ethyladenosine sulfate
Homo sapiens
P17707
-
0.07
5'-[(3-aminopropyl)methylamino]-5'-deoxy-8-methyladenosine sulfate
Homo sapiens
P17707
-
0.5
5'-[(3-aminopropyl)methylamino]-5'-deoxyadenosine sulfate
Homo sapiens
P17707
-
0.000049
5'-[(4-aminooxybutyl)methylamino]-5'-deoxy-8-(methylamino)adenosine sulfate
Homo sapiens
P17707
-
0.000015
5'-[(4-aminooxybutyl)methylamino]-5'-deoxy-8-ethyladenosine sulfate
Homo sapiens
P17707
-
0.000005
5'-[(4-aminooxybutyl)methylamino]-5'-deoxy-8-methyladenosine sulfate
Homo sapiens
P17707
-
0.000011
5'-[(4-aminooxybutyl)methylamino]-5'-deoxy-8-oxoadenosine sulfate
Homo sapiens
P17707
-
0.000018
5'-[(4-aminooxybutyl)methylamino]-5'-deoxyadenosine sulfate
Homo sapiens
P17707
-
0.001
MDL73811
Plasmodium falciparum
-
-
SPECIFIC ACTIVITY [µmol/min/mg]
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
0.0005
-
without activator
0.00126
-
-
0.088
-
native wild type AdoMetDC enzyme, in 50 mM KH2PO4 pH 7.5, 1 mM EDTA, 1 mM dithiothreitol, at 37C
0.102
-
-
0.14
-
recombinant AdoMetDC enzyme, in 50 mM KH2PO4 pH 7.5, 1 mM EDTA, 1 mM dithiothreitol, at 37C
1.3
-
without activator
1.992
-
-
8
-
plus 2 mM 1,15-diamino-4,12-diazapentadecane; plus 2 mM 33-003
19
-
pus 2 mM YZ-33-050C
26
-
plus 2 mM PMW-2000-11-13-5
46
-
plus 2 mM YZ-33-046
79
-
plus 2 mM putrescine
121
-
plus 2 mM YZ-33-050C
148
-
plus 2 mM 33-003
152
-
plus 2 mM PMW-2000-11-13-5
176
-
plus 2 mM YZ-33-046
180
-
plus 2 mM 1,15-diamono-4,12-diazapentadecane
410
-
plus 2 mM putrescine
additional information
pH OPTIMUM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
7.2 - 7.4
-
-
7.3 - 7.4
-
phosphate buffer
7.5
-
-
7.5 - 8
-
spermidine-stimulated enzyme
8.6
-
-
pH RANGE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
6.8 - 7.3
-
wild-type enzyme
7.2 - 7.8
-
K81A mutant
7.2 - 9.5
-
pH 7.2: about 45% of maximal activity, pH 9.5: about 65% of maximal activity
TEMPERATURE OPTIMUM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
30
-
assay at
40
-
-
TEMPERATURE RANGE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
50 - 90
-
50C: about 45% of maximal activity, 90C: about 60% of maximal activity
SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SOURCE
-
-
Manually annotated by BRENDA team
-
high level of OsSAMDC mRNA
Manually annotated by BRENDA team
-
from salivary gland, culture on fibronectin-, collagen I gel-, and Matrigel-coated substrates for 12-24 h upregulates S-adenosylmethionine decarboxylase mRNA expression and enzyme activity compared to cells cultured on non-precoated substrates
Manually annotated by BRENDA team
-
moderate level of OsSAMDC mRNA
Manually annotated by BRENDA team
-
intermediate level of OsSAMDC mRNA
Manually annotated by BRENDA team
-
high level of OsSAMDC mRNA
Manually annotated by BRENDA team
-
MRC5, diploid, embryonic, uninfected or infected with cytomegalovirus
Manually annotated by BRENDA team
-
transfected MCF-7
Manually annotated by BRENDA team
-
high level of OsSAMDC mRNA
Manually annotated by BRENDA team
nucellus, integuments and inner epidermis tissues of fertilized ovules
Manually annotated by BRENDA team
-
high levels of soluble SAMDCare found starting from the late uninucleate microspore stage, very high SAMDC activity is found in the wall residues of the aborted pollen
Manually annotated by BRENDA team
-
epithelial cell, culture on fibronectin-, collagen I gel-, and Matrigel-coated substrates for 12-24 h upregulates S-adenosylmethionine decarboxylase mRNA expression and enzyme activity compared to cells cultured on non-precoated substrates
Manually annotated by BRENDA team
-
germination is accompanied by a rapid increase in enzyme activity and maximal activity occurs in 5-day-old seedlings
Manually annotated by BRENDA team
additional information