4.1.1.50: adenosylmethionine decarboxylase
This is an abbreviated version!
For detailed information about adenosylmethionine decarboxylase, go to the full flat file.
Word Map on EC 4.1.1.50
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4.1.1.50
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polyamine
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spermidine
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putrescine
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methylglyoxal
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bisguanylhydrazone
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diamine
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alpha-difluoromethylornithine
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brucei
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prostate
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decarboxylases
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l-ornithine
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trypanosoma
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n1-acetyltransferase
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antiproliferative
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proenzyme
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pyruvoyl
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aminopropyltransferases
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agmatine
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agriculture
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1,3-diaminopropane
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synthesis
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pentamidine
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trypanosomatids
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n1-acetylspermidine
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medicine
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pao
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pharmacology
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adenosyltransferase
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antizyme
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dl-alpha-difluoromethylornithine
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glyoxal
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drought
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rhodesiense
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trypanosomiasis
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analysis
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trypanothione
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guanylhydrazone
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difluoromethylornithine
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uorfs
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normfinder
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methylthioadenosine
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biotechnology
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arginase
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polyamine-depleted
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cadaverine
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genorm
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berenil
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enzyme-activated
- 4.1.1.50
- polyamine
- spermidine
- putrescine
- methylglyoxal
- bisguanylhydrazone
- diamine
- alpha-difluoromethylornithine
- brucei
- prostate
- decarboxylases
- l-ornithine
- trypanosoma
-
n1-acetyltransferase
-
antiproliferative
- proenzyme
-
pyruvoyl
- aminopropyltransferases
- agmatine
- agriculture
- 1,3-diaminopropane
- synthesis
- pentamidine
-
trypanosomatids
- n1-acetylspermidine
- medicine
- pao
- pharmacology
-
adenosyltransferase
- antizyme
- dl-alpha-difluoromethylornithine
- glyoxal
- drought
- rhodesiense
- trypanosomiasis
- analysis
- trypanothione
-
guanylhydrazone
- difluoromethylornithine
-
uorfs
-
normfinder
- methylthioadenosine
- biotechnology
- arginase
-
polyamine-depleted
- cadaverine
-
genorm
- berenil
-
enzyme-activated
Reaction
Synonyms
Ado-MetDC, AdoMet decarboxylase, AdoMetDC, AdoMetDC/ODC, AMDC, BjSAMDC1, BjSAMDC2, BjSAMDC3, BjSAMDC4, BlsE, Bud2, MdSAMDC1, MdSAMDC2, OsSAMDC, PfAdoMetDC, protein SSO0585, S-adenosyl methionine decarboxylase, S-Adenosyl-L-methionine decarboxylase, S-adenosyl-methionine-decarboxylase, S-adenosylmethionine decarboxy-lase/ornithine decarboxylase, S-Adenosylmethionine decarboxylase, S-adenosylmethionine decarboxylase 1, S-adenosylmethionine decarboxylase 2, S-adenosylmethionine decarboxylase 3, S-adenosylmethionine decarboxylase 4, SAM decarboxylase, SAM-DC, SAMDC, SvPEPC, Tb927.6.4410
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General Information
General Information on EC 4.1.1.50 - adenosylmethionine decarboxylase
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malfunction
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overexpression of S-adenosylmethionine decarboxylase in rodent fibroblasts leads to aggressive transformants (Amdc-s cells) that have high invasive capacity in nude mice, invading rapidly from the subcutaneous injection site into the peritoneal cavity and its organs. Amdc-s-induced tumors show chaotic neovascularization, with abundant pleomorphic vessel-like structures that have noncontiguous or totally missing laminin (basement membrane) and CD31 (endothelial cell) immunoreactivity
metabolism
physiological function
metabolism
S-adenosylmethionine decarboxylase is a critical pyruvoyl-dependent enzyme in the polyamine-biosynthetic pathway
metabolism
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S-adenosylmethionine decarboxylase is the rate-limiting enzyme for polyamine biosynthesis
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AdoMetDC activity controls the expression levels of the other spermidine biosynthetic enzymes
physiological function
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S-adenosylmethionine decarboxylase is a key enzyme in the biosynthesis of polyamines essential for cell proliferation
physiological function
the expression of SAMDC is involved in the ovary development
physiological function
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expression of the yeast enzyme in tomato reverses the ripening associated decline in spermidine and spermine levels observed in the azygous control fruit. About 2-3fold higher levels of labeled-spermidine in transgenic fruit expressing yeast enzyme confirm the enzymatic function of the introduced gene
physiological function
silencing of S-adenosylmethionine decarboxylase and spermine synthase in cotton leaves leads to a significant accumulation of upstream substrates and, ultimately, enhanced plant susceptibility to Verticillium dahliae infection. Constitutive expression of S-adenosylmethionine decarboxylase in Arabidopsis thaliana is associated with greater Verticillium wilt resistance and higher accumulations of spermine, salicylic acid, and leucine during the infection period. Transgenic Arabidopsis plants that overexpress S-adenosylmethionine decarboxylase are more susceptible than the wild-type to Vermicillium dahliae and they also have impaired levels of putrescine and salicylic acid
physiological function
transgenic Arabidopsis thaliana constitutively expressing SAMDC show significantly enhanced drought tolerance. The levels of main polyamines are more significantly increased in SAMDC-overexpressing transgenic plants after 6 h of drought stress as compared to stressed wild-type plants. Basal transcription of polyamine oxidase shows a much higher level in unstressed-transgenic plants compared to wild-type. ROS-induced transcription of the metacaspase II gene is remarkably inhibited in transgenic plants