3.6.1.55: 8-oxo-dGTP diphosphatase

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For detailed information about 8-oxo-dGTP diphosphatase, go to the full flat file.

Reaction

Synonyms

7,8-dihydro-8-oxo-dGTP pyrophosphohydrolase, 8-oxo-2'-deoxyguanosine triphosphatase, 8-oxo-dG triphosphatase, 8-oxo-dGTP diphosphatase, 8-oxo-dGTP hydrolase, 8-oxo-dGTPase, AK369000, CiMutT, MTH1, MuT, MutT, MutT homolog 1, MutT homologue 1, MutT2, Nudix hydrolase, NUDT1, Nudx12

ECTree

     3 Hydrolases

         3.6 Acting on acid anhydrides

             3.6.1 In phosphorus-containing anhydrides

                3.6.1.55 8-oxo-dGTP diphosphatase

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Results	in table
3965	AA Sequence
8	Cloned(Commentary)
4	Crystallization (Commentary)
210	Disease/ Diagnostics
3	Expression
6	General Information
11	IC50 Value
17	Inhibitors
2	kcat/KM [mM/s]
16	Ki Value [mM]
12	KM Value [mM]
7	Metals/Ions
2	Molecular Weight [Da]
17	Natural Substrates/ Products (Substrates)
21	Organism
1	Pathway
189	PDB ID
6	pH Optimum
1	pH Range
5	Purification (Commentary)
1	Reaction
21	Reference
4	Source Tissue
2	Specific Activity [micromol/min/mg]
68	Substrates and Products (Substrate)
1	Subunits
33	Synonyms
1	Systematic Name
6	Temperature Optimum [°C]
1	Temperature Range [°C]
1	Temperature Stability [°C]
2	Turnover Number [1/s]

Natural Substrates Products

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Natural Substrates Products on EC 3.6.1.55 - 8-oxo-dGTP diphosphatase

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NATURAL SUBSTRATE

NATURAL PRODUCT

REACTION DIAGRAM

ORGANISM

UNIPROT

COMMENTARY
(Substrate)

LITERATURE
(Substrate)

COMMENTARY
(Product)

LITERATURE
(Product)

REVERSIBILITY
r=reversible
ir=irreversible
?=not specified

8-oxo-dGDP + H2O

8-oxo-dGMP + phosphate

Escherichia coli

-

-

667672

-

-

?

8-oxo-dGTP + H2O

8-oxo-dGMP + diphosphate

11 entries

8-oxo-GDP + H2O

8-oxo-GMP + phosphate

Escherichia coli

-

-

667672

-

-

?

8-oxo-GTP + H2O

8-oxo-GMP + diphosphate

Escherichia coli

-

the MutT protein eliminates 8-oxoGTP and prevents the occurrence of transcriptional errors, which are induced particularly in the aerobic state

716365

-

-

?

8-oxo-dGTP + H2O

8-oxo-dGMP + diphosphate

Ciona intestinalis

-

-

715113

-

-

?

8-oxo-dGTP + H2O

8-oxo-dGMP + diphosphate

Ciona intestinalis

-

the oxidized nucleotide precursors 8-oxo-dGTP is readily incorporated into nascent DNA strands during replication, which would cause base substitution mutations. 8-oxo-dGTP diphosphatase (8-oxo-dGTP diphosphatase) enzyme has the potential to prevent mutations by 8-oxo-dGTP in Ciona intestinalis

715113

-

-

?

8-oxo-dGTP + H2O

8-oxo-dGMP + diphosphate

Escherichia coli

-

-

654634, 715439, 716070

-

-

?

8-oxo-dGTP + H2O

8-oxo-dGMP + diphosphate

Escherichia coli

-

8-oxo-dGTP i.e. 8-oxo-7,8-dihydro-2'-deoxyguanosine 5'-triphosphate

715460

-

-

?

8-oxo-dGTP + H2O

8-oxo-dGMP + diphosphate

Escherichia coli

-

8-oxoguanine (8-oxo-7,8-dihydroguanine) is produced in nucleic acids as well as in nucleotide pools of cells, by reactive oxygen species normally formed during cellular metabolic processes. MutT protein of Escherichia coli specifically degrades 8-oxoGua-containing deoxyribo- and ribonucleoside triphosphates to corresponding nucleoside monophosphates, thereby preventing misincorporation of 8-oxoguanine into DNA and RNA, which would cause mutation and phenotypic suppression, respectively

667672

-

-

?

8-oxo-dGTP + H2O

8-oxo-dGMP + diphosphate

Escherichia coli

-

MutT molecules are needed for keeping the spontaneous mutation frequency at the normal level. The MutT functions are not needed under anaerobic condition, yet the level of the MutT protein in cell is kept constant, probably for preparing for sudden changes of oxygen pressure

716300

-

-

?

8-oxo-dGTP + H2O

8-oxo-dGMP + diphosphate

Escherichia coli

-

prevents replicational errors by degrading 8-oxo-dGTP, a potent mutagenic substrate for DNA synthesis. Elimination from the nucleotide pool of the oxidized form of guanine nucleotide is important for the high fidelity of DNA synthesis

716320

-

-

?

8-oxo-dGTP + H2O

8-oxo-dGMP + diphosphate

Escherichia coli

P08337

the activity of MutT can prevent the misincorporation of 8-oxoguanine opposite adenine in DNA

715573

-

-

?

8-oxo-dGTP + H2O

8-oxo-dGMP + diphosphate

Escherichia coli

-

the MutT protein specifically hydrolyzes both 8-oxo-deoxyguanosine triphosphate (8-oxo-dGTP) and 8-oxo-guanosine triphosphate (8-oxo-GTP), which are otherwise incorporated in DNA and RNA opposite template A. This cleaning of the nucleotide pools decreases both DNA replication and transcription errors

716917

-

-

?

8-oxo-dGTP + H2O

8-oxo-dGMP + diphosphate

Escherichia coli CC101

-

MutT molecules are needed for keeping the spontaneous mutation frequency at the normal level. The MutT functions are not needed under anaerobic condition, yet the level of the MutT protein in cell is kept constant, probably for preparing for sudden changes of oxygen pressure

716300

-

-

?

8-oxo-dGTP + H2O

8-oxo-dGMP + diphosphate

Homo sapiens

-

-

755779, 756449

-

-

?