Literature summary for 3.6.1.55 extracted from

Ishibashi, T.; Hayakawa, H.; Ito, R.; Miyazawa, M.; Yamagata, Y.; Sekiguchi, M.
Mammalian enzymes for preventing transcriptional errors caused by oxidative damage (2005), Nucleic Acids Res., 33, 3779-3784.

Search for more literature for 3.6.1.55

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
8-oxo-GTP + H2O	Escherichia coli	the MutT protein eliminates 8-oxoGTP and prevents the occurrence of transcriptional errors, which are induced particularly in the aerobic state	8-oxo-GMP + diphosphate	-	?

Organism

Organism	UniProt	Comment	Textmining
Escherichia coli	-	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
8-oxo-dGTP + H2O	-	Escherichia coli	8-oxo-dGMP + diphosphate	-	?
8-oxo-GTP + H2O	the MutT protein eliminates 8-oxoGTP and prevents the occurrence of transcriptional errors, which are induced particularly in the aerobic state	Escherichia coli	8-oxo-GMP + diphosphate	-	?

Synonyms

Synonyms	Comment	Organism
MutT	-	Escherichia coli

General Information

General Information	Comment	Organism
malfunction	the increase in the production of erroneous proteins by oxidative damage is 28fold over the wild-type cells in Escherichia coli mutT deficient cells	Escherichia coli
physiological function	is produced in cells by reactive oxygen species normally formed during cellular metabolic processes. This oxidized base can pair with both adenine and cytosine, and thus the existence of this base in messenger RNA would cause translational errors. The MutT protein of Escherichia coli degrades 8-oxoGua-containing ribonucleoside di- and triphosphates to the monophosphate, thereby preventing the misincorporation of 8-oxoGua into RNA	Escherichia coli

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Release 2023.1 (January 2023)