3.6.1.55: 8-oxo-dGTP diphosphatase
This is an abbreviated version!
For detailed information about 8-oxo-dGTP diphosphatase, go to the full flat file.
Word Map on EC 3.6.1.55
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3.6.1.55
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glycosylase
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sanitize
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8-oxoguanine
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nudix
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misincorporation
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8-oxo-dgmp
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8-oxo-7,8-dihydro-2'-deoxyguanosine
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8-oxo-7,8-dihydrodeoxyguanosine
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mutyh
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promutagenic
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8-oxo-7,8-dihydroguanine
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8-oxodgtpase
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antimutator
- 3.6.1.55
- glycosylase
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sanitize
- 8-oxoguanine
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nudix
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misincorporation
- 8-oxo-dgmp
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8-oxo-7,8-dihydro-2'-deoxyguanosine
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8-oxo-7,8-dihydrodeoxyguanosine
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mutyh
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promutagenic
- 8-oxo-7,8-dihydroguanine
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8-oxodgtpase
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antimutator
Reaction
Synonyms
7,8-dihydro-8-oxo-dGTP pyrophosphohydrolase, 8-oxo-2'-deoxyguanosine triphosphatase, 8-oxo-dG triphosphatase, 8-oxo-dGTP diphosphatase, 8-oxo-dGTP hydrolase, 8-oxo-dGTPase, AK369000, CiMutT, MTH1, MuT, MutT, MutT homolog 1, MutT homologue 1, MutT2, Nudix hydrolase, NUDT1, Nudx12
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General Information
General Information on EC 3.6.1.55 - 8-oxo-dGTP diphosphatase
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malfunction
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the increase in the production of erroneous proteins by oxidative damage is 28fold over the wild-type cells in Escherichia coli mutT deficient cells
physiological function
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is produced in cells by reactive oxygen species normally formed during cellular metabolic processes. This oxidized base can pair with both adenine and cytosine, and thus the existence of this base in messenger RNA would cause translational errors. The MutT protein of Escherichia coli degrades 8-oxoGua-containing ribonucleoside di- and triphosphates to the monophosphate, thereby preventing the misincorporation of 8-oxoGua into RNA
physiological function
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MutT molecules are needed for keeping the spontaneous mutation frequency at the normal level. The MutT functions are not needed under anaerobic condition, yet the level of the MutT protein in cell is kept constant, probably for preparing for sudden changes of oxygen pressure
physiological function
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the enzyme prevents replicational errors by degrading 8-oxo-dGTP, a potent mutagenic substrate for DNA synthesis. Elimination from the nucleotide pool of the oxidized form of guanine nucleotide is important for the high fidelity of DNA synthesis
physiological function
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the oxidized nucleotide precursors 8-oxo-dGTP is readily incorporated into nascent DNA strands during replication, which would cause base substitution mutations. 8-oxo-dGTP diphosphatase (8-oxo-dGTP diphosphatase) enzyme has the potential to prevent mutations by 8-oxo-dGTP in Ciona intestinalis
physiological function
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MutT molecules are needed for keeping the spontaneous mutation frequency at the normal level. The MutT functions are not needed under anaerobic condition, yet the level of the MutT protein in cell is kept constant, probably for preparing for sudden changes of oxygen pressure
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