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Literature summary for 3.6.1.55 extracted from

  • Taddei, F.; Hayakawa, H.; Bouton, M.; Cirinesi, A.; Matic, I.; Sekiguchi, M.; Radman, M.
    Counteraction by MutT protein of transcriptional errors caused by oxidative damage (1997), Science, 278, 128-130.
    View publication on PubMed

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
8-oxo-dGTP + H2O Escherichia coli the MutT protein specifically hydrolyzes both 8-oxo-deoxyguanosine triphosphate (8-oxo-dGTP) and 8-oxo-guanosine triphosphate (8-oxo-GTP), which are otherwise incorporated in DNA and RNA opposite template A. This cleaning of the nucleotide pools decreases both DNA replication and transcription errors 8-oxo-dGMP + diphosphate
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Organism

Organism UniProt Comment Textmining
Escherichia coli
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
8-oxo-dGTP + H2O
-
Escherichia coli 8-oxo-dGMP + diphosphate
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?
8-oxo-dGTP + H2O the MutT protein specifically hydrolyzes both 8-oxo-deoxyguanosine triphosphate (8-oxo-dGTP) and 8-oxo-guanosine triphosphate (8-oxo-GTP), which are otherwise incorporated in DNA and RNA opposite template A. This cleaning of the nucleotide pools decreases both DNA replication and transcription errors Escherichia coli 8-oxo-dGMP + diphosphate
-
?

Synonyms

Synonyms Comment Organism
MutT
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Escherichia coli