3.6.1.55: 8-oxo-dGTP diphosphatase
This is an abbreviated version!
For detailed information about 8-oxo-dGTP diphosphatase, go to the full flat file.
Word Map on EC 3.6.1.55
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3.6.1.55
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glycosylase
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sanitize
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8-oxoguanine
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nudix
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misincorporation
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8-oxo-dgmp
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8-oxo-7,8-dihydro-2'-deoxyguanosine
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8-oxo-7,8-dihydrodeoxyguanosine
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mutyh
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promutagenic
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8-oxo-7,8-dihydroguanine
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8-oxodgtpase
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antimutator
- 3.6.1.55
- glycosylase
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sanitize
- 8-oxoguanine
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nudix
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misincorporation
- 8-oxo-dgmp
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8-oxo-7,8-dihydro-2'-deoxyguanosine
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8-oxo-7,8-dihydrodeoxyguanosine
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mutyh
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promutagenic
- 8-oxo-7,8-dihydroguanine
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8-oxodgtpase
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antimutator
Reaction
Synonyms
7,8-dihydro-8-oxo-dGTP pyrophosphohydrolase, 8-oxo-2'-deoxyguanosine triphosphatase, 8-oxo-dG triphosphatase, 8-oxo-dGTP diphosphatase, 8-oxo-dGTP hydrolase, 8-oxo-dGTPase, AK369000, CiMutT, MTH1, MuT, MutT, MutT homolog 1, MutT homologue 1, MutT2, Nudix hydrolase, NUDT1, Nudx12
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Systematic Name
Systematic Name on EC 3.6.1.55 - 8-oxo-dGTP diphosphatase
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8-oxo-dGTP diphosphohydrolase
This enzyme hydrolyses the phosphoanhydride bond between the alpha and beta phosphate of 8-oxoguanine-containing nucleoside di- and triphosphates thereby preventing misincorporation of the oxidized purine nucleoside triphosphates into DNA. It does not hydrolyse 2-hydroxy-dATP (cf. EC 3.6.1.56, 2-hydroxy-dATP diphosphatase) [4]. Requires Mg2+.