3.6.1.55: 8-oxo-dGTP diphosphatase

This is an abbreviated version!
For detailed information about 8-oxo-dGTP diphosphatase, go to the full flat file.

Word Map on EC 3.6.1.55

3.6.1.55

glycosylase

sanitize

8-oxoguanine

nudix

misincorporation

8-oxo-dgmp

8-oxo-7,8-dihydro-2'-deoxyguanosine

8-oxo-7,8-dihydrodeoxyguanosine

mutyh

promutagenic

8-oxo-7,8-dihydroguanine

8-oxodgtpase

antimutator

Reaction

Synonyms

7,8-dihydro-8-oxo-dGTP pyrophosphohydrolase, 8-oxo-2'-deoxyguanosine triphosphatase, 8-oxo-dG triphosphatase, 8-oxo-dGTP diphosphatase, 8-oxo-dGTP hydrolase, 8-oxo-dGTPase, AK369000, CiMutT, MTH1, MuT, MutT, MutT homolog 1, MutT homologue 1, MutT2, Nudix hydrolase, NUDT1, Nudx12

ECTree

3 Hydrolases

3.6 Acting on acid anhydrides

3.6.1 In phosphorus-containing anhydrides

3.6.1.55 8-oxo-dGTP diphosphatase

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Results	in table
3965	AA Sequence
8	Cloned(Commentary)
4	Crystallization (Commentary)
210	Disease/ Diagnostics
3	Expression
6	General Information
11	IC50 Value
17	Inhibitors
2	kcat/KM [mM/s]
16	Ki Value [mM]
12	KM Value [mM]
7	Metals/Ions
2	Molecular Weight [Da]
17	Natural Substrates/ Products (Substrates)
21	Organism
1	Pathway
189	PDB ID
6	pH Optimum
1	pH Range
5	Purification (Commentary)
1	Reaction
21	Reference
4	Source Tissue
2	Specific Activity [micromol/min/mg]
68	Substrates and Products (Substrate)
1	Subunits
33	Synonyms
1	Systematic Name
6	Temperature Optimum [°C]
1	Temperature Range [°C]
1	Temperature Stability [°C]
2	Turnover Number [1/s]

Inhibitors

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Inhibitors on EC 3.6.1.55 - 8-oxo-dGTP diphosphatase

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(S)-crizotinib

Homo sapiens

756449

2-hydroxy-dADP

Homo sapiens

inhibitory at low-micromolar concentrations

756449

2-[2-[(6-methoxy-3-methyl-1H-pyrazolo[3,4-b]quinolin-4-yl)amino]ethoxy]ethanol

Homo sapiens

i.e. SCH51344

756449

6-(2,3-dichlorophenyl)-N4-methylpyrimidine-2,4-diamine

Homo sapiens

i.e. TH287, strongest inhibitor

7-deaza-dGTP

7-iodo-7-deaza-dGTP

8-bromo-7-deaza-dGTP

8-bromo-dGTP

8-chloro-7-deaza-dGTP

Homo sapiens

756449

8-iodo-7-deaza-2'-deoxyguanosine

8-iodo-7-deaza-dGTP

8-oxo-dGDP

inhibitory at low-micromolar concentrations

756449

8-oxo-dGMP

Escherichia coli

noncompetitive inhibitor of dGTP hydrolysis

654634

dGMP

Escherichia coli

noncompetitive inhibitor of dGTP hydrolysis

dGTP

diphosphate

linear uncompetitive inhibitor of dGTP hydrolysis

654634

N4-cyclopropyl-6-(2,3-dichlorophenyl)pyrimidine-2,4-diamine

Homo sapiens

i.e. TH588

755779