3.6.1.53: Mn2+-dependent ADP-ribose/CDP-alcohol diphosphatase
This is an abbreviated version!
For detailed information about Mn2+-dependent ADP-ribose/CDP-alcohol diphosphatase, go to the full flat file.
Word Map on EC 3.6.1.53
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3.6.1.53
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dithiothreitol
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adp-ribosylation
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nonenzymatic
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phosphohydrolysis
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cadpr
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napqi
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pyrophosphatases
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cdp-alcohols
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n-acetyl-p-benzoquinoneimine
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nitroprusside
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hepatotoxicity
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acetaminophen
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rodent
- 3.6.1.53
- dithiothreitol
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adp-ribosylation
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nonenzymatic
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phosphohydrolysis
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cadpr
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napqi
- pyrophosphatases
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cdp-alcohols
- n-acetyl-p-benzoquinoneimine
- nitroprusside
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hepatotoxicity
- acetaminophen
- rodent
Reaction
Synonyms
ADP-ribose/CDP-alcohol diphosphatase, ADPRibase-I, ADPRibase-II, ADPRibase-Mn, Adprm, cADPR phosphohydrolase, Mn(2+)-dependent ADP-ribose/CDP-alcohol pyrophosphatase, Mn2+-dependent ADP-ribose/CDP-alcohol pyrophosphatase, More
ECTree
3.6.1.53 Mn2+-dependent ADP-ribose/CDP-alcohol diphosphataseAdvanced search results
results (
results (Substrates Products
Substrates Products on EC 3.6.1.53 - Mn2+-dependent ADP-ribose/CDP-alcohol diphosphatase
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SUBSTRATE 
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
adenosine 5'-diphospho-5'-adenosine + H2O
AMP
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45% of the activity with ADP-ribose
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?
ADP + H2O
?
27% activity at 0.5 mM substrate compared to ADP-ribose
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-
?
CDP-ethanolamine + H2O
?
89% activity at 0.5 mM substrate compared to ADP-ribose
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-
?
CDP-glycerol + H2O
?
89% activity at 0.5 mM substrate compared to ADP-ribose
-
-
?
IDP-ribose + H2O
IMP + D-ribose 5-phosphate
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-
105% of the activity with ADP-ribose
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?
ADP-ribose + H2O
AMP + D-ribose 5-phosphate
100% activity at 0.5 mM substrate
-
-
?
CDP-choline + H2O
CMP + phosphocholine
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140% of the activity with ADP-ribose
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-
?
CDP-choline + H2O
CMP + phosphocholine
156% of the activity with ADP-ribose
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-
?
CDP-choline + H2O
CMP + phosphocholine
140% activity at 0.5 mM substrate compared to ADP-ribose
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-
?
CDP-ethanolamine + H2O
CMP + phosphoethanolamine
84% of the activity with ADP-ribose
-
-
?
CDP-ethanolamine + H2O
CMP + phosphoethanolamine
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89% of the activity with ADP-ribose
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-
?
CDP-glycerol + H2O
CMP + phosphoglycerol
103% of the activity with ADP-ribose
-
-
?
CDP-glycerol + H2O
CMP + phosphoglycerol
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89% of the activity with ADP-ribose
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-
?
cyclic ADP-ribose + H2O
N1-(5-phosphoribosyl)-AMP
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cADPR is an ADPRibase-Mn ligand and substrate
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-
?
cyclic ADP-ribose + H2O
N1-(5-phosphoribosyl)-AMP
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ADPRibase-Mn activity on cyclic ADP-ribose is 65fold less efficient than on ADP-ribose
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-
?
cyclic ADP-ribose + H2O
N1-(5-phosphoribosyl)-AMP
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product determination and analysis, cADPR is an ADPRibase-Mn ligand and substrate. ADPRibase-Mn activity on cADPR is 65fold less efficient than on ADP-ribose, the best substrate. Phosphohydrolytic pattern of the reaction, overview
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-
?
additional information
?
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very poor substrate: cyclic ADP-ribose. No substrate: ADP-glucose, UDP-glucose, CDP-glucose, CDP, CMP, AMP or 3',5'-cAMP
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-
?
additional information
?
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ADP-ribose/CDP-alcohol diphosphatase (ADPRibase-Mn) acts as cyclic ADP-ribose (cADPR) phosphohydrolase with much lower efficiency than on its major substrates
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additional information
?
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ADPRibase-Mn hydrolyzes the phosphoanhydride linkages of ADP-ribose, CDP-choline, CDP-glycerol, CDP-ethanolamine, and ADP with decreasing efficiencies, requiring low micromolar Mn2+ concentrations not substituted by Mg2+. ADPRibase-Mn hydrolyzes ADP-ribose, CDP-choline, CDP-glycerol and CDP-ethanolamine with decreasing catalytic efficiencies
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-
?
additional information
?
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ADP-glucose, UDP-glucose, CDP-glucose, CDP, CMP, and AMP are not hydrolysed
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-
?
