3.6.1.53: Mn2+-dependent ADP-ribose/CDP-alcohol diphosphatase

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For detailed information about Mn2+-dependent ADP-ribose/CDP-alcohol diphosphatase, go to the full flat file.

Reaction

Synonyms

ADP-ribose/CDP-alcohol diphosphatase, ADPRibase-I, ADPRibase-II, ADPRibase-Mn, Adprm, cADPR phosphohydrolase, Mn(2+)-dependent ADP-ribose/CDP-alcohol pyrophosphatase, Mn2+-dependent ADP-ribose/CDP-alcohol pyrophosphatase, More

ECTree

     3 Hydrolases

         3.6 Acting on acid anhydrides

             3.6.1 In phosphorus-containing anhydrides

                3.6.1.53 Mn2+-dependent ADP-ribose/CDP-alcohol diphosphatase

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Results	in table
980	AA Sequence
3	Cloned(Commentary)
4	Crystallization (Commentary)
2	General Information
2	Inhibitors
69	kcat/KM [mM/s]
70	KM Value [mM]
10	Metals/Ions
5	Molecular Weight [Da]
8	Natural Substrates/ Products (Substrates)
8	Organism
7	pH Optimum
3	pH Range
1	pH Stability
1	pI Value
22	Protein Variants
4	Purification (Commentary)
2	Reaction
7	Reference
9	Source Tissue
2	Specific Activity [micromol/min/mg]
1	Storage Stability
43	Substrates and Products (Substrate)
3	Subunits
15	Synonyms
1	Systematic Name
2	Temperature Optimum [°C]
69	Turnover Number [1/s]

General Information

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General Information on EC 3.6.1.53 - Mn2+-dependent ADP-ribose/CDP-alcohol diphosphatase

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GENERAL INFORMATION

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

evolution

Homo sapiens

Q3LIE5

ADPRibase-Mn enzymes contain the dinuclear metal centre typical of the metallo-dependent phosphatases SCOP2 superfamily, forming within it a family of their own named as ADPRibase-Mn-like. ADPRibase-Mn proteins constitute also a functional family in the CATH classification, within cluster SC:3 of superfamily 3.60.21.10

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physiological function

Homo sapiens

Q3LIE5

cyclic ADP-ribose (cADPR) is a messenger for Ca2+ mobilization. Its turnover is believed to occur by glycohydrolysis to ADP-ribose. ADP-ribose/CDP-alcohol diphosphatase (ADPRibase-Mn) acts as cADPR phosphohydrolase with much lower efficiency than on its major substrates

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