3.6.1.53: Mn2+-dependent ADP-ribose/CDP-alcohol diphosphatase
This is an abbreviated version!
For detailed information about Mn2+-dependent ADP-ribose/CDP-alcohol diphosphatase, go to the full flat file.
Word Map on EC 3.6.1.53
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3.6.1.53
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dithiothreitol
-
adp-ribosylation
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nonenzymatic
-
phosphohydrolysis
-
cadpr
-
napqi
-
pyrophosphatases
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cdp-alcohols
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n-acetyl-p-benzoquinoneimine
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nitroprusside
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hepatotoxicity
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acetaminophen
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rodent
- 3.6.1.53
- dithiothreitol
-
adp-ribosylation
-
nonenzymatic
-
phosphohydrolysis
-
cadpr
-
napqi
- pyrophosphatases
-
cdp-alcohols
- n-acetyl-p-benzoquinoneimine
- nitroprusside
-
hepatotoxicity
- acetaminophen
- rodent
Reaction
Synonyms
ADP-ribose/CDP-alcohol diphosphatase, ADPRibase-I, ADPRibase-II, ADPRibase-Mn, Adprm, cADPR phosphohydrolase, Mn(2+)-dependent ADP-ribose/CDP-alcohol pyrophosphatase, Mn2+-dependent ADP-ribose/CDP-alcohol pyrophosphatase, More
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Metals Ions
Metals Ions on EC 3.6.1.53 - Mn2+-dependent ADP-ribose/CDP-alcohol diphosphatase
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Mn2+
additional information
required, similar activatory effects with all the substrates tested. Km values around 1 microM and 2.5 mM Mn2+ for ADP-ribose hydrolysis
Mn2+
required. Concentration of MnCl2 giving the half-maximal rate is 0.001-0.004 mM. Mn2+ cannot be replaced by Mg2+
Mn2+
dependent on, ADPRibase-Mn is inactive without added Mn2+, and it shows a high affinity for the cation, since saturation is observed at low-micromolar concentrations of Mn2+ well below the substrate concentration (0.5 mM), in no case can Mg2+ replace Mn2+