3.6.1.53: Mn2+-dependent ADP-ribose/CDP-alcohol diphosphatase

This is an abbreviated version!
For detailed information about Mn2+-dependent ADP-ribose/CDP-alcohol diphosphatase, go to the full flat file.

Word Map on EC 3.6.1.53

3.6.1.53

dithiothreitol

adp-ribosylation

nonenzymatic

phosphohydrolysis

cadpr

napqi

pyrophosphatases

cdp-alcohols

n-acetyl-p-benzoquinoneimine

nitroprusside

hepatotoxicity

acetaminophen

rodent

Reaction

Synonyms

ADP-ribose/CDP-alcohol diphosphatase, ADPRibase-I, ADPRibase-II, ADPRibase-Mn, Adprm, cADPR phosphohydrolase, Mn(2+)-dependent ADP-ribose/CDP-alcohol pyrophosphatase, Mn2+-dependent ADP-ribose/CDP-alcohol pyrophosphatase, More

ECTree

3 Hydrolases

3.6 Acting on acid anhydrides

3.6.1 In phosphorus-containing anhydrides

3.6.1.53 Mn2+-dependent ADP-ribose/CDP-alcohol diphosphatase

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Results	in table
980	AA Sequence
3	Cloned(Commentary)
4	Crystallization (Commentary)
2	General Information
2	Inhibitors
69	kcat/KM [mM/s]
70	KM Value [mM]
10	Metals/Ions
5	Molecular Weight [Da]
8	Natural Substrates/ Products (Substrates)
8	Organism
7	pH Optimum
3	pH Range
1	pH Stability
1	pI Value
22	Protein Variants
4	Purification (Commentary)
2	Reaction
7	Reference
9	Source Tissue
2	Specific Activity [micromol/min/mg]
1	Storage Stability
43	Substrates and Products (Substrate)
3	Subunits
15	Synonyms
1	Systematic Name
2	Temperature Optimum [°C]
69	Turnover Number [1/s]

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Reference on EC 3.6.1.53 - Mn2+-dependent ADP-ribose/CDP-alcohol diphosphatase

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209868

Canales, J.; Pinto, R.M.; Costas, M.J.; Hernandez, M.T.; Miro, A.; Bernet, D.; Fernandez, A.; Cameselle, J.C.

Rat liver nucleoside diphosphosugar or diphosphoalcohol pyrophosphatase different from nucleotide pyrophosphatase or phosphodiesterase I: substrate specificities of Mg2+- and/or Mn2+-depeneent hydrolases acting on ADP-ribose

Biochim. Biophys. Acta

1246

167-177

1995

Rattus norvegicus

7819284

690823

Canales, J.; Fernandez, A.; Ribeiro, J.M.; Cabezas, A.; Rodrigues, J.R.; Cameselle, J.C.; Costas, M.J.

Mn2+-dependent ADP-ribose/CDP-alcohol pyrophosphatase: a novel metallophosphoesterase family preferentially expressed in rodent immune cells

Biochem. J.

413

103-113

2008

Rattus norvegicus (Q5M886), Mus musculus (Q99KS6), Mus musculus

18352857

697946

Canales, J.; Fernandez, A.; Rodrigues, J.R.; Ferreira, R.; Ribeiro, J.M.; Cabezas, A.; Costas, M.J.; Cameselle, J.C.

Hydrolysis of the phosphoanhydride linkage of cyclic ADP-ribose by the Mn(2+)-dependent ADP-ribose/CDP-alcohol pyrophosphatase

FEBS Lett.

583

1593-1598

2009

Rattus norvegicus

19379742

735009

Cabezas, A.; Ribeiro, J.; Rodrigues, J.; Lopez-Villamizar, I.; Fernandez, A.; Canales, J.; Pinto, R.; Costas, M.; Cameselle, J.

Molecular bases of catalysis and ADP-ribose preference of human Mn2+-dependent adpribose/CDP-alcohol diphosphatase and conversion by mutagenesis to a preferential cyclic ADP-ribose phosphohydrolase

PLoS ONE

e0118680

2015

Homo sapiens (W0NWJ0), Homo sapiens

25692488

735057

Rodrigues, J.; Fernandez, A.; Canales, J.; Cabezas, A.; Ribeiro, J.; Costas, M.; Cameselle, J.

Characterization of Danio rerio Mn2+-dependent ADP-ribose/CDP-alcohol diphosphatase, the structural prototype of the ADPRibase-Mn-like protein family

PLoS ONE

e42249

2012

Danio rerio (Q7T291)

22848751

758417

Ribeiro, J.M.; Canales, J.; Cabezas, A.; Rodrigues, J.R.; Pinto, R.M.; Lopez-Villamizar, I.; Costas, M.J.; Cameselle, J.C.

Specific cyclic ADP-ribose phosphohydrolase obtained by mutagenic engineering of Mn2+-dependent ADP-ribose/CDP-alcohol diphosphatase

Sci. Rep.

1036

2018

Homo sapiens (Q3LIE5)

29348648