3.6.1.53: Mn2+-dependent ADP-ribose/CDP-alcohol diphosphatase
This is an abbreviated version!
For detailed information about Mn2+-dependent ADP-ribose/CDP-alcohol diphosphatase, go to the full flat file.
Word Map on EC 3.6.1.53
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3.6.1.53
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dithiothreitol
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adp-ribosylation
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nonenzymatic
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phosphohydrolysis
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cadpr
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napqi
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pyrophosphatases
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cdp-alcohols
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n-acetyl-p-benzoquinoneimine
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nitroprusside
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hepatotoxicity
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acetaminophen
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rodent
- 3.6.1.53
- dithiothreitol
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adp-ribosylation
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nonenzymatic
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phosphohydrolysis
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cadpr
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napqi
- pyrophosphatases
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cdp-alcohols
- n-acetyl-p-benzoquinoneimine
- nitroprusside
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hepatotoxicity
- acetaminophen
- rodent
Reaction
Synonyms
ADP-ribose/CDP-alcohol diphosphatase, ADPRibase-I, ADPRibase-II, ADPRibase-Mn, Adprm, cADPR phosphohydrolase, Mn(2+)-dependent ADP-ribose/CDP-alcohol pyrophosphatase, Mn2+-dependent ADP-ribose/CDP-alcohol pyrophosphatase, More
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Natural Substrates Products
Natural Substrates Products on EC 3.6.1.53 - Mn2+-dependent ADP-ribose/CDP-alcohol diphosphatase
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REACTION DIAGRAM
cyclic ADP-ribose + H2O
N1-(5-phosphoribosyl)-AMP
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cADPR is an ADPRibase-Mn ligand and substrate
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ADP-ribose/CDP-alcohol diphosphatase (ADPRibase-Mn) acts as cyclic ADP-ribose (cADPR) phosphohydrolase with much lower efficiency than on its major substrates
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additional information
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ADPRibase-Mn hydrolyzes the phosphoanhydride linkages of ADP-ribose, CDP-choline, CDP-glycerol, CDP-ethanolamine, and ADP with decreasing efficiencies, requiring low micromolar Mn2+ concentrations not substituted by Mg2+. ADPRibase-Mn hydrolyzes ADP-ribose, CDP-choline, CDP-glycerol and CDP-ethanolamine with decreasing catalytic efficiencies
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