3.6.1.53: Mn2+-dependent ADP-ribose/CDP-alcohol diphosphatase
This is an abbreviated version!
For detailed information about Mn2+-dependent ADP-ribose/CDP-alcohol diphosphatase, go to the full flat file.
Word Map on EC 3.6.1.53
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3.6.1.53
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dithiothreitol
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adp-ribosylation
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nonenzymatic
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phosphohydrolysis
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cadpr
-
napqi
-
pyrophosphatases
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cdp-alcohols
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n-acetyl-p-benzoquinoneimine
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nitroprusside
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hepatotoxicity
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acetaminophen
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rodent
- 3.6.1.53
- dithiothreitol
-
adp-ribosylation
-
nonenzymatic
-
phosphohydrolysis
-
cadpr
-
napqi
- pyrophosphatases
-
cdp-alcohols
- n-acetyl-p-benzoquinoneimine
- nitroprusside
-
hepatotoxicity
- acetaminophen
- rodent
Reaction
Synonyms
ADP-ribose/CDP-alcohol diphosphatase, ADPRibase-I, ADPRibase-II, ADPRibase-Mn, Adprm, cADPR phosphohydrolase, Mn(2+)-dependent ADP-ribose/CDP-alcohol pyrophosphatase, Mn2+-dependent ADP-ribose/CDP-alcohol pyrophosphatase, More
ECTree
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Systematic Name
Systematic Name on EC 3.6.1.53 - Mn2+-dependent ADP-ribose/CDP-alcohol diphosphatase
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CDP-choline phosphohydrolase
Requires Mn2+. Unlike EC 3.6.1.13, ADP-ribose diphosphatase, it cannot utilize Mg2+. ADP-D-ribose, CDP-choline, CDP-ethanolamine and ADP are substrates for this enzyme but ADP-D-glucose, UDP-D-glucose, CDP-D-glucose, CDP, CMP and AMP are not hydrolysed [2]. The mammalian enzyme hydrolyses cyclic ADP-ribose to 1-(5-phospho-beta-D-ribosyl)-AMP with ~100-fold lower efficiency than ADP-D-ribose [3]. In rat, the enzyme is found predominantly in thymus and spleen.