3.6.1.13: ADP-ribose diphosphatase
This is an abbreviated version!
For detailed information about ADP-ribose diphosphatase, go to the full flat file.
Word Map on EC 3.6.1.13
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3.6.1.13
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pyrophosphatases
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melastatin
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mutt-related
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ribose-5'-phosphate
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adp-sugars
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8-oxo-dgdp
- 3.6.1.13
- pyrophosphatases
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melastatin
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mutt-related
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ribose-5'-phosphate
- adp-sugars
- 8-oxo-dgdp
Reaction
Synonyms
adenosine 5'-diphosphosugar pyrophosphatase, adenosine diphosphoribose pyrophosphatase, ADP-ribose diphosphatase, ADP-ribose hydrolase, ADP-ribose phosphohydrolase, ADP-ribose pyrophosphatase, ADP-ribose pyrophosphatase Sll1054, ADP-ribose pyrophosphatase Slr0920, ADP-ribose pyrophosphatase Slr1134, ADP-ribose pyrophosphatase-I, ADP-ribose/CDP-alcohol diphosphatase, ADP-ribose/NADH pyrophosphohydrolase, ADPR pyrophosphatase, ADPR-PPase, ADPRase, ADPRase-I, ADPRibase, ADPRibase-Mn, ADPribose pyrophosphatase, Adprm, AT4G12720, AtNUDT10, AtNUDT2, AtNUDT6, AtNUDT7, AtNUDX7, cADPR phosphohydrolase, CinA, cyclic ADPR phosphohydrolase, DR2204, EcADPRase, mNUDT5 protein, More, MT1739, MtADPRase, MutT/nudix family protein, NadM-Nudix, Ndx2, Ndx4, NMN adenylyltransferase/ADP-ribose pyrophosphatase, Nudix hydrolase, Nudix hydrolase 7, NUDT5, NUDT5 protein, NUDT9, NUDT9 protein, NUDT9alpha protein, NUDX2, NUDX7, NuhA, pyrophosphatase, adenosine diphosphoribose, submicromolar-K(m) ADP-ribose pyrophosphatase, TtADPRase, YSA1H, zgc:64213
ECTree
3.6.1.13 ADP-ribose diphosphataseAdvanced search results
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results (Inhibitors
Inhibitors on EC 3.6.1.13 - ADP-ribose diphosphatase
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INHIBITOR 
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
IMAGE
5-amino-3-(morpholin-4-yl)-1,2,3-oxadiazol-3-ium
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3-morpholinosynonimine increases Km and slightly decreases Vmax
8-oxo-dGDP
the ADP-ribose cleavage is competitively inhibited by 8-oxo-dGDP (68% relative cleavage efficiency at 0.01 mM)
8-oxo-dGMP
the ADP-ribose cleavage is competitively inhibited by 8-oxo-dGMP (89% relative cleavage efficiency at 0.01 mM)
ADP-ribose
the 8-oxo-dGDP cleavage is competitively inhibited by ADP-ribose (22% relative cleavage efficiency at 0.005 mM)
AMP
the 8-oxo-dGDP cleavage is competitively inhibited by AMP (30% relative cleavage efficiency at 0.005 mM)
fluoride
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inhibition of Mg2+-dependent activity of ADP-ribose pyrophosphatase. the Mn2+-dependent activity is not affected by fluoride
N-acetyl-p-benzoquinoneimine
1 mM, almost complete inhibition of activity towards ADPribose. The inhibitor is a useful tool for distinguishing the specific ADP-ribose diphosphatase from the less specific ADP-sugar diphosphatases
N-acetyl-p-benzoquinoneimine
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decreases Vmax to 30% of control values and increases the Km for ADPribose 2-3fold
nitroprusside
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nitroprusside in presence of dithiothreitol diminishes Vmax and increases Km
nitroprusside
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sodium nitroprusside increases Km without appreciably affecting Vmax
additional information
no inhibitory effect is observed with 8-oxo-dGMP
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