3.6.1.13: ADP-ribose diphosphatase

This is an abbreviated version!
For detailed information about ADP-ribose diphosphatase, go to the full flat file.

Reaction

Synonyms

adenosine 5'-diphosphosugar pyrophosphatase, adenosine diphosphoribose pyrophosphatase, ADP-ribose diphosphatase, ADP-ribose hydrolase, ADP-ribose phosphohydrolase, ADP-ribose pyrophosphatase, ADP-ribose pyrophosphatase Sll1054, ADP-ribose pyrophosphatase Slr0920, ADP-ribose pyrophosphatase Slr1134, ADP-ribose pyrophosphatase-I, ADP-ribose/CDP-alcohol diphosphatase, ADP-ribose/NADH pyrophosphohydrolase, ADPR pyrophosphatase, ADPR-PPase, ADPRase, ADPRase-I, ADPRibase, ADPRibase-Mn, ADPribose pyrophosphatase, Adprm, AT4G12720, AtNUDT10, AtNUDT2, AtNUDT6, AtNUDT7, AtNUDX7, cADPR phosphohydrolase, CinA, cyclic ADPR phosphohydrolase, DR2204, EcADPRase, mNUDT5 protein, More, MT1739, MtADPRase, MutT/nudix family protein, NadM-Nudix, Ndx2, Ndx4, NMN adenylyltransferase/ADP-ribose pyrophosphatase, Nudix hydrolase, Nudix hydrolase 7, NUDT5, NUDT5 protein, NUDT9, NUDT9 protein, NUDT9alpha protein, NUDX2, NUDX7, NuhA, pyrophosphatase, adenosine diphosphoribose, submicromolar-K(m) ADP-ribose pyrophosphatase, TtADPRase, YSA1H, zgc:64213

ECTree

     3 Hydrolases

         3.6 Acting on acid anhydrides

             3.6.1 In phosphorus-containing anhydrides

                3.6.1.13 ADP-ribose diphosphatase

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Results	in table
1	Activating Compound
11166	AA Sequence
1	CAS Registry Number
32	Cloned(Commentary)
17	Crystallization (Commentary)
101	Disease/ Diagnostics
3	Expression
15	General Information
1	IC50 Value
38	Inhibitors
91	kcat/KM [mM/s]
2	Ki Value [mM]
160	KM Value [mM]
11	Localization
58	Metals/Ions
22	Molecular Weight [Da]
35	Natural Substrates/ Products (Substrates)
160	Organism
4	Pathway
283	PDB ID
19	pH Optimum
6	pH Range
4	pI Value
84	Protein Variants
35	Purification (Commentary)
4	Reaction
1	Reaction Type
65	Reference
129	Source Tissue
5	Specific Activity [micromol/min/mg]
1	Storage Stability
163	Substrates and Products (Substrate)
16	Subunits
121	Synonyms
1	Systematic Name
6	Temperature Optimum [°C]
1	Temperature Range [°C]
2	Temperature Stability [°C]
142	Turnover Number [1/s]

KCat KM Value

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KCat KM Value on EC 3.6.1.13 - ADP-ribose diphosphatase

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kcat/KM VALUE [1/mMs^-1]

SUBSTRATE

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

IMAGE

17.3

2''-O-acetyl-ADP-ribose

Mus musculus

-

at pH 7.5 and 37°C

740674

0.1 - 32

2',3'-cAMP

16 entries

0.0011 - 0.66

ADP

2 entries

0.0027 - 630

ADP-D-ribose

21 entries

0.03 - 1000

ADP-ribose

16 entries

0.0001 - 44

cADP-ribose

15 entries

0.002 - 180

CDP-choline

16 entries

0.007 - 32

CDP-ethanolamine

2 entries

0.12 - 48

CDP-glycerol

2 entries

0.1

2',3'-cAMP

Homo sapiens

W0NWJ0

mutant N110A, pH 7.5, 37°C

735009

0.13

2',3'-cAMP

Homo sapiens

W0NWJ0

mutant R43A, pH 7.5, 37°C

735009

0.4

2',3'-cAMP

Homo sapiens

W0NWJ0

mutant F210A, pH 7.5, 37°C

735009

1.9

2',3'-cAMP

Homo sapiens

W0NWJ0

mutant Q27H, pH 7.5, 37°C

735009

3.9

2',3'-cAMP

Homo sapiens

W0NWJ0

mutant F37A/L196F, pH 7.5, 37°C

735009

4

2',3'-cAMP

Homo sapiens

W0NWJ0

mutant F37A/L196A, pH 7.5, 37°C

735009

4

2',3'-cAMP

Homo sapiens

W0NWJ0

mutant F37A/L196F/C253A, pH 7.5, 37°C

735009

6

2',3'-cAMP

Homo sapiens

W0NWJ0

mutant H111A, pH 7.5, 37°C

735009

7

2',3'-cAMP

Homo sapiens

W0NWJ0

mutant F37A, pH 7.5, 37°C

735009

9

2',3'-cAMP

Homo sapiens

W0NWJ0

mutant L196A, pH 7.5, 37°C

735009

18

2',3'-cAMP

Danio rerio

Q7T291

mutant H97A, pH 7.5, temperature not specified in the publication

735057

19

2',3'-cAMP

Homo sapiens

W0NWJ0

mutant H111N, pH 7.5, 37°C

735009

22

2',3'-cAMP

Danio rerio

Q7T291

wild-type, pH 7.5, temperature not specified in the publication

735057

25

2',3'-cAMP

Homo sapiens

W0NWJ0

wild-type, pH 7.5, 37°C

735009

28

2',3'-cAMP

Homo sapiens

W0NWJ0

mutant F37Y, pH 7.5, 37°C

735009

32

2',3'-cAMP

Homo sapiens

W0NWJ0

mutant C253A, pH 7.5, 37°C

735009

0.0011

ADP

Danio rerio

Q7T291

mutant H97A, pH 7.5, temperature not specified in the publication

735057

0.66

ADP

Danio rerio

Q7T291

wild-type, pH 7.5, temperature not specified in the publication

735057

0.0027

ADP-D-ribose

Homo sapiens

Q9UKK9

mutant enzyme E112Q, at pH 7.0 and 37°C

688413

0.005

ADP-D-ribose

Homo sapiens

Q9UKK9

mutant enzyme W28A/W46A, at pH 7.0 and 37°C

688413

0.23

ADP-D-ribose

Homo sapiens

Q9UKK9

mutant enzyme E116Q, at pH 7.0 and 37°C

688413

1.2

ADP-D-ribose

Homo sapiens

Q9UKK9

mutant enzyme R51Q, at pH 7.0 and 37°C

688413

1.7

ADP-D-ribose

Homo sapiens

Q9UKK9

mutant enzyme R84Q, at pH 7.0 and 37°C

688413

4.3

ADP-D-ribose

Homo sapiens

Q9UKK9

mutant enzyme E166Q, at pH 7.0 and 37°C

688413

13

ADP-D-ribose

Homo sapiens

Q9UKK9

mutant enzyme R111Q, at pH 7.0 and 37°C

688413

19.6

ADP-D-ribose

Mus musculus

-

at pH 7.5 and 37°C

740674

50

ADP-D-ribose

Homo sapiens

Q9UKK9

mutant enzyme R196Q, at pH 7.0 and 37°C

688413

67

ADP-D-ribose

Homo sapiens

Q9UKK9

mutant enzyme E115Q, at pH 7.0 and 37°C

688413

72

ADP-D-ribose

Homo sapiens

Q9UKK9

mutant enzyme W28A, at pH 7.0 and 37°C

688413

81

ADP-D-ribose

Homo sapiens

Q9UKK9

mutant enzyme Q82A, at pH 7.0 and 37°C

688413

83

ADP-D-ribose

Homo sapiens

Q9UKK9

mutant enzyme D133A, at pH 7.0 and 37°C

688413

89

ADP-D-ribose

Homo sapiens

Q9UKK9

mutant enzyme W46A, at pH 7.0 and 37°C

688413

97

ADP-D-ribose

Homo sapiens

Q9UKK9

mutant enzyme L98A, at pH 7.0 and 37°C

688413

120

ADP-D-ribose

Homo sapiens

Q9UKK9

mutant enzyme E93Q, at pH 7.0 and 37°C

688413

230

ADP-D-ribose

Homo sapiens

Q9UKK9

mutant enzyme D133N, at pH 7.0 and 37°C

688413

300

ADP-D-ribose

Homo sapiens

Q9UKK9

mutant enzyme C139A, at pH 7.0 and 37°C

688413

390

ADP-D-ribose

Homo sapiens

Q9UKK9

mutant enzyme D164A, at pH 7.0 and 37°C

688413

530

ADP-D-ribose

Homo sapiens

Q9UKK9

wild type enzyme, at pH 7.0 and 37°C

688413

630

ADP-D-ribose

Homo sapiens

Q9UKK9

mutant enzyme D164N, at pH 7.0 and 37°C

688413

0.03

ADP-ribose

Homo sapiens

W0NWJ0

mutant R43A, pH 7.5, 37°C

735009

3

ADP-ribose

Homo sapiens

W0NWJ0

mutant H111A, pH 7.5, 37°C

735009

4.8

ADP-ribose

Homo sapiens

W0NWJ0

mutant F37A/L196F, pH 7.5, 37°C

735009

5.9

ADP-ribose

Danio rerio

Q7T291

mutant H97A, pH 7.5, temperature not specified in the publication

735057

6

ADP-ribose

Homo sapiens

W0NWJ0

mutant F37A/L196A, pH 7.5, 37°C

735009

9

ADP-ribose

Homo sapiens

W0NWJ0

mutant F210A, pH 7.5, 37°C

735009

11

ADP-ribose

Homo sapiens

W0NWJ0

mutant F37A/L196F/C253A, pH 7.5, 37°C

735009

12

ADP-ribose

Homo sapiens

W0NWJ0

mutant F37A, pH 7.5, 37°C

735009

15

ADP-ribose

Homo sapiens

W0NWJ0

mutant N110A, pH 7.5, 37°C

735009

29

ADP-ribose

Homo sapiens

W0NWJ0

mutant H111N, pH 7.5, 37°C

735009

52

ADP-ribose

Homo sapiens

W0NWJ0

mutant Q27H, pH 7.5, 37°C

735009

120

ADP-ribose

Homo sapiens

W0NWJ0

mutant L196A, pH 7.5, 37°C

735009

340

ADP-ribose

Danio rerio

Q7T291

wild-type, pH 7.5, temperature not specified in the publication

735057

590

ADP-ribose

Homo sapiens

W0NWJ0

wild-type, pH 7.5, 37°C

735009

650

ADP-ribose

Homo sapiens

W0NWJ0

mutant F37Y, pH 7.5, 37°C

735009

1000

ADP-ribose

Homo sapiens

W0NWJ0

mutant C253A, pH 7.5, 37°C

735009

0.0001

cADP-ribose

Homo sapiens

W0NWJ0

mutant R43A, pH 7.5, 37°C

735009

0.008

cADP-ribose

Homo sapiens

W0NWJ0

mutant F210A, pH 7.5, 37°C

735009

0.028

cADP-ribose

Danio rerio

Q7T291

wild-type, pH 7.5, temperature not specified in the publication

735057

0.07

cADP-ribose

Homo sapiens

W0NWJ0

mutant H111A, pH 7.5, 37°C

735009

0.13

cADP-ribose

Homo sapiens

W0NWJ0

mutant N110A, pH 7.5, 37°C

735009

0.15

cADP-ribose

Homo sapiens

W0NWJ0

mutant Q27H, pH 7.5, 37°C

735009

0.29

cADP-ribose

Homo sapiens

W0NWJ0

mutant H111N, pH 7.5, 37°C

735009

0.9

cADP-ribose

Homo sapiens

W0NWJ0

mutant F37A/L196A, pH 7.5, 37°C

735009

0.9

cADP-ribose

Homo sapiens

W0NWJ0

mutant L196A, pH 7.5, 37°C

735009

1.3

cADP-ribose

Homo sapiens

W0NWJ0

mutant F37A, pH 7.5, 37°C

735009

1.6

cADP-ribose

Homo sapiens

W0NWJ0

mutant F37A/L196F, pH 7.5, 37°C

735009

4

cADP-ribose

Homo sapiens

W0NWJ0

wild-type, pH 7.5, 37°C

735009

4.1

cADP-ribose

Homo sapiens

W0NWJ0

mutant F37Y, pH 7.5, 37°C

735009

35.5

cADP-ribose

Homo sapiens

W0NWJ0

mutant F37A/L196F/C253A, pH 7.5, 37°C

735009

44

cADP-ribose

Homo sapiens

W0NWJ0

mutant C253A, pH 7.5, 37°C

735009

0.002

CDP-choline

Danio rerio

Q7T291

mutant H97A, pH 7.5, temperature not specified in the publication

735057

0.006

CDP-choline

Homo sapiens

W0NWJ0

mutant R43A, pH 7.5, 37°C

735009

0.3

CDP-choline

Homo sapiens

W0NWJ0

mutant H111A, pH 7.5, 37°C

735009

1.5

CDP-choline

Homo sapiens

W0NWJ0

mutant N110A, pH 7.5, 37°C

735009

2

CDP-choline

Homo sapiens

W0NWJ0

mutant H111N, pH 7.5, 37°C

735009

4

CDP-choline

Homo sapiens

W0NWJ0

mutant F210A, pH 7.5, 37°C

735009

5.6

CDP-choline

Danio rerio

Q7T291

wild-type, pH 7.5, temperature not specified in the publication

735057

14

CDP-choline

Homo sapiens

W0NWJ0

mutant Q27H, pH 7.5, 37°C

735009

17

CDP-choline

Homo sapiens

W0NWJ0

mutant F37A/L196F, pH 7.5, 37°C

735009

21

CDP-choline

Homo sapiens

W0NWJ0

mutant F37A/L196A, pH 7.5, 37°C

735009

22

CDP-choline

Homo sapiens

W0NWJ0

mutant F37A/L196F/C253A, pH 7.5, 37°C

735009

34

CDP-choline

Homo sapiens

W0NWJ0

mutant F37A, pH 7.5, 37°C

735009

62

CDP-choline

Homo sapiens

W0NWJ0

mutant L196A, pH 7.5, 37°C

735009

150

CDP-choline

Homo sapiens

W0NWJ0

wild-type, pH 7.5, 37°C

735009

160

CDP-choline

Homo sapiens

W0NWJ0

mutant C253A, pH 7.5, 37°C

735009

180

CDP-choline

Homo sapiens

W0NWJ0

mutant F37Y, pH 7.5, 37°C

735009

0.007

CDP-ethanolamine

Danio rerio

Q7T291

mutant H97A, pH 7.5, temperature not specified in the publication

735057

32

CDP-ethanolamine

Danio rerio

Q7T291

wild-type, pH 7.5, temperature not specified in the publication

735057

0.12

CDP-glycerol

Danio rerio

Q7T291

mutant H97A, pH 7.5, temperature not specified in the publication

735057

48

CDP-glycerol

Danio rerio

Q7T291

wild-type, pH 7.5, temperature not specified in the publication

735057