Literature summary for 3.6.1.13 extracted from

Lin, S.; Gasmi, L.; Xie, Y.; Ying, K.; Gu, S.; Wang, Z.; Jin, H.; Chao, Y.; Wu, C.; Zhou, Z.; Tang, R.; Mao, Y.; McLennan, A.G.
Cloning, expression and characterisation of a human Nudix hydrolase specific for adenosine 5'-diphosphoribose (ADP-ribose) (2001), Biochim. Biophys. Acta, 1594, 127-135.

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Cloned(Commentary)

Cloned (Comment)	Organism
expression in Escherichia coli	Homo sapiens

Inhibitors

Inhibitors	Comment	Organism	Structure
F-	-	Homo sapiens
N-acetyl-p-benzoquinoneimine	1 mM, almost complete inhibition of activity towards ADPribose. The inhibitor is a useful tool for distinguishing the specific ADP-ribose diphosphatase from the less specific ADP-sugar diphosphatases	Homo sapiens

KM Value [mM]

KM Value [mM]	KM Value Maximum [mM]	Substrate	Comment	Organism	Structure
0.18	-	ADPribose	-	Homo sapiens

Metals/Ions

Metals/Ions	Comment	Organism	Structure
Mg2+	activates	Homo sapiens
Mn2+	activates	Homo sapiens

Molecular Weight [Da]

Molecular Weight [Da]	Molecular Weight Maximum [Da]	Comment	Organism
47000	-	x * 47000, SDS-PAGE	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	Q9BW91	Nudix motif	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
ADPribose + H2O	-	Homo sapiens	AMP + D-ribose 5-phosphate	-	?
IDPribose + H2O	77% of the activity with ADPribose	Homo sapiens	IMP + D-ribose 5-phosphate	-	?

Subunits

Subunits	Comment	Organism
?	x * 47000, SDS-PAGE	Homo sapiens

Synonyms

Synonyms	Comment	Organism
NUDT9alpha protein	-	Homo sapiens

Turnover Number [1/s]

Turnover Number Minimum [1/s]	Turnover Number Maximum [1/s]	Substrate	Comment	Organism	Structure
8	-	ADPribose	-	Homo sapiens

pH Optimum

pH Optimum Minimum	pH Optimum Maximum	Comment	Organism
8	10	-	Homo sapiens

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Release 2023.1 (January 2023)