3.6.1.13: ADP-ribose diphosphatase

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For detailed information about ADP-ribose diphosphatase, go to the full flat file.

Word Map on EC 3.6.1.13

3.6.1.13

pyrophosphatases

melastatin

mutt-related

ribose-5'-phosphate

adp-sugars

8-oxo-dgdp

Reaction

Synonyms

adenosine 5'-diphosphosugar pyrophosphatase, adenosine diphosphoribose pyrophosphatase, ADP-ribose diphosphatase, ADP-ribose hydrolase, ADP-ribose phosphohydrolase, ADP-ribose pyrophosphatase, ADP-ribose pyrophosphatase Sll1054, ADP-ribose pyrophosphatase Slr0920, ADP-ribose pyrophosphatase Slr1134, ADP-ribose pyrophosphatase-I, ADP-ribose/CDP-alcohol diphosphatase, ADP-ribose/NADH pyrophosphohydrolase, ADPR pyrophosphatase, ADPR-PPase, ADPRase, ADPRase-I, ADPRibase, ADPRibase-Mn, ADPribose pyrophosphatase, Adprm, AT4G12720, AtNUDT10, AtNUDT2, AtNUDT6, AtNUDT7, AtNUDX7, cADPR phosphohydrolase, CinA, cyclic ADPR phosphohydrolase, DR2204, EcADPRase, mNUDT5 protein, More, MT1739, MtADPRase, MutT/nudix family protein, NadM-Nudix, Ndx2, Ndx4, NMN adenylyltransferase/ADP-ribose pyrophosphatase, Nudix hydrolase, Nudix hydrolase 7, NUDT5, NUDT5 protein, NUDT9, NUDT9 protein, NUDT9alpha protein, NUDX2, NUDX7, NuhA, pyrophosphatase, adenosine diphosphoribose, submicromolar-K(m) ADP-ribose pyrophosphatase, TtADPRase, YSA1H, zgc:64213

ECTree

3 Hydrolases

3.6 Acting on acid anhydrides

3.6.1 In phosphorus-containing anhydrides

3.6.1.13 ADP-ribose diphosphatase

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Results	in table
1	Activating Compound
11166	AA Sequence
1	CAS Registry Number
32	Cloned(Commentary)
17	Crystallization (Commentary)
101	Disease/ Diagnostics
3	Expression
15	General Information
1	IC50 Value
38	Inhibitors
91	kcat/KM [mM/s]
2	Ki Value [mM]
160	KM Value [mM]
11	Localization
58	Metals/Ions
22	Molecular Weight [Da]
35	Natural Substrates/ Products (Substrates)
160	Organism
4	Pathway
283	PDB ID
19	pH Optimum
6	pH Range
4	pI Value
84	Protein Variants
35	Purification (Commentary)
4	Reaction
1	Reaction Type
65	Reference
129	Source Tissue
5	Specific Activity [micromol/min/mg]
1	Storage Stability
163	Substrates and Products (Substrate)
16	Subunits
121	Synonyms
1	Systematic Name
6	Temperature Optimum [°C]
1	Temperature Range [°C]
2	Temperature Stability [°C]
142	Turnover Number [1/s]

Purification

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Purification on EC 3.6.1.13 - ADP-ribose diphosphatase

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7 entries

acetaminophen-treated animals and controls

Rattus norvegicus

209870

ADP-ribose pyrophosphatase Sll1054

Synechocystis sp.

669102

ADP-ribose pyrophosphatase Slr0920

Synechocystis sp.

669102

ADP-ribose pyrophosphatase Slr1134

Synechocystis sp.

669102

ADPRibaseI, ADPribase II and ADPRibase-Mn

Rattus norvegicus

209868

ADPribose pyrophosphatase I

Rattus norvegicus

209870

ammonium sulfate precipitation, Toyopearl Phenyl-650M column chromatography, and Q Sepharose column chromatography

AtNUDT10

AtNUDT2

AtNUDT6

AtNUDT7

Ni-NTA column chromatography and Q-Sepharose column chromatography

Homo sapiens

Q9UKK9

715902

Ni-Sepharose 6 column chromatography, HisTrap column chromatography, and Superdex 75 gel filtration

partial

recombinant enzyme

recombinant GST-tagged enzyme from Escherichia coli by glutathione affinity chromatography, the tag is cleaved off by TEV protease, and the detagged protein is further purified by anion exchange chromatography

Francisella tularensis

Q5NHR1

690090

recombinant GST-tagged wild-type and mutant enzymes from Escherichia coli strain BL21 by glutathione affinity chromatography, proteolytic tag cleavage

Homo sapiens

Q3LIE5

758417

recombinant His-tagged enzyme from Escherichia coli strain Bl21 by nickel affinity and anion exchange chromatography, and gel filtration

Synechocystis sp.

Q55928

690090

recombinant His6-tagged enzyme from Escherichia coli strain BL21(DE3) by nickel affinity chromatography

Autographa californica multiple nucleopolyhedrovirus

690189

recombinant His6-tagged NUDT5 from Escherichia coli strain BL21 by nickel affinity chromatography

Homo sapiens

684834

recombinant Ndx2 from Escherichia coli strain BL21(DE3) by heat treatment at 70°C for 15 min and ion exchange chromatography

Thermus thermophilus

Q84CU3

687404

Talon resin column chromatography

Homo sapiens

Q9UKK9

715407