3.5.2.10: creatininase

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For detailed information about creatininase, go to the full flat file.

Reaction

Synonyms

creatinine amidohydrolase, creatinine hydrolase, CrnA

ECTree

     3 Hydrolases

         3.5 Acting on carbon-nitrogen bonds, other than peptide bonds

             3.5.2 In cyclic amides

                3.5.2.10 creatininase

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Results	in table
1	Activating Compound
2108	AA Sequence
5	Application
1	CAS Registry Number
6	Cloned(Commentary)
6	Crystallization (Commentary)
5	Disease/ Diagnostics
1	General Stability
19	Inhibitors
8	kcat/KM [mM/s]
13	KM Value [mM]
13	Metals/Ions
10	Molecular Weight [Da]
8	Natural Substrates/ Products (Substrates)
18	Organism
1	Oxidation Stability
5	Pathway
72	PDB ID
5	pH Optimum
4	pH Range
3	pH Stability
1	Posttranslational Modification
9	Protein Variants
5	Purification (Commentary)
4	Reaction
1	Reaction Type
17	Reference
1	Renatured (Commentary)
2	Source Tissue
11	Specific Activity [micromol/min/mg]
4	Storage Stability
19	Substrates and Products (Substrate)
8	Subunits
3	Synonyms
1	Systematic Name
4	Temperature Optimum [°C]
4	Temperature Stability [°C]
8	Turnover Number [1/s]

Engineering

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Engineering on EC 3.5.2.10 - creatininase

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PROTEIN VARIANTS

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

E122Q

Pseudomonas putida

P83772

almost complete loss of activity

712749

E183Q

Pseudomonas putida

P83772

complete loss of activity

712749

H178A

Pseudomonas putida

P83772

complete loss of activity

712749

W154A

Pseudomonas putida

P83772

complete loss of activity

712749

W154F

Pseudomonas putida

P83772

almost complete loss of activity

712749

W174A

Pseudomonas putida

P83772

almost complete loss of activity

712749

W174F

Pseudomonas putida

P83772

about 50% of wild-type activity

712749

Y121A

Pseudomonas putida

P83772

about 10% of wild-type catalytic efficiency

712749

additional information

Homo sapiens

-

construction of an electrochemical biosensor for creatinine based on the immobilization of creatininase, creatinase and sarcosine oxidase onto a ferrocene/horseradish peroxidase/gold nanoparticles/multi-walled carbon nanotubes/Teflon composite electrode,method development and evaluation, overview

733713