3.5.1.99: fatty acid amide hydrolase

0.001

(10Z)-1-bromononadec-10-en-2-one

0.0009

(10Z)-2-oxononadec-10-enamide

0.000047

(5Z,8Z,11Z,14Z)-1-pyridazin-3-ylicosa-5,8,11,14-tetraen-1-one

0.000001

(5Z,8Z,11Z,14Z)-1-[1,3]oxazolo[4,5-b]pyridin-2-ylicosa-5,8,11,14-tetraen-1-one

0.000002

(5Z,8Z,11Z,14Z)-1-[1,3]oxazolo[4,5-c]pyridin-2-ylicosa-5,8,11,14-tetraen-1-one

0.000018

(5Z,8Z,11Z,14Z)-1-[1,3]oxazolo[5,4-c]pyridin-2-ylicosa-5,8,11,14-tetraen-1-one

0.00015

(9E)-1-pyridazin-3-yloctadec-9-en-1-one

0.0000032

(9E)-1-[1,3]oxazolo[4,5-b]pyridin-2-yloctadec-9-en-1-one

0.00037

(9Z)-1-(1,3-benzoxazol-2-yl)octadec-9-en-1-one

0.000017

(9Z)-1-(1,3-oxazol-2-yl)octadec-9-en-1-one

0.0037

(9Z)-1-(1-methyl-1H-tetrazol-5-yl)octadec-9-en-1-one

0.0098

(9Z)-1-(1H-tetrazol-5-yl)octadec-9-en-1-one

0.000065

(9Z)-1-(2-methyl-2H-tetrazol-5-yl)octadec-9-en-1-one

0.0045

(9Z)-1-(4,5-dihydro-1,3-oxazol-2-yl)octadec-9-en-1-one

0.013

(9Z)-1-(7-methyl-1,3-benzoxazol-2-yl)octadec-9-en-1-one

0.00054

(9Z)-1-pyrazin-2-yloctadec-9-en-1-one

0.00013

(9Z)-1-pyridazin-3-yloctadec-9-en-1-one

0.0025

(9Z)-1-pyrimidin-2-yloctadec-9-en-1-one

0.00011

(9Z)-1-pyrimidin-4-yloctadec-9-en-1-one

0.0000023

(9Z)-1-[1,3]oxazolo[4,5-b]pyridin-2-yloctadec-9-en-1-one

0.0000072

(9Z)-1-[1,3]oxazolo[4,5-c]pyridin-2-yloctadec-9-en-1-one

0.000011

(9Z)-1-[1,3]oxazolo[5,4-b]pyridin-2-yloctadec-9-en-1-one

0.0000037

(9Z)-1-[1,3]oxazolo[5,4-c]pyridin-2-yloctadec-9-en-1-one

0.0085

(9Z)-octadec-9-enal

0.000038

(phenylamino)[[(E)-[1-[3-(thiophen-2-yl)phenyl]ethylidene]amino]oxy]methanone

pH 8.4, 37°C

719048

0.0035

1,1'-(5,5'-bi-1,3-oxazole-2,2'-diyl)bis(7-phenylheptan-1-one)

0.0024

1-(1,3-benzoxazol-2-yl)octadecan-1-one

0.000048

1-(1,3-oxazol-2-yl)-7-phenylheptan-1-one

0.000002

1-(5-acetyl-1,3-oxazol-2-yl)-7-phenylheptan-1-one

0.000003

1-(5-bromo-1,3-oxazol-2-yl)-7-phenylheptan-1-one

0.000005

1-(5-chloro-1,3-oxazol-2-yl)-7-phenylheptan-1-one

0.00003

1-(5-fluoro-1,3-oxazol-2-yl)-7-phenylheptan-1-one

0.000012

1-(5-furan-2-yl-1,3-oxazol-2-yl)-7-phenylheptan-1-one

0.000003

1-(5-iodo-1,3-oxazol-2-yl)-7-phenylheptan-1-one

0.00008

1-(5-methyl-1,3-oxazol-2-yl)-7-phenylheptan-1-one

0.0007

1-pyridazin-3-yloctadecan-1-one

0.0000069

1-[1,3]oxazolo[4,5-b]pyridin-2-yl-4-phenylbutan-1-one

0.0000003

1-[1,3]oxazolo[4,5-b]pyridin-2-yl-5-phenylpentan-1-one

0.0000002

1-[1,3]oxazolo[4,5-b]pyridin-2-yl-6-phenylhexan-1-one

0.00000028

1-[1,3]oxazolo[4,5-b]pyridin-2-yl-7-phenylheptan-1-one

0.00000039

1-[1,3]oxazolo[4,5-b]pyridin-2-yl-8-phenyloctan-1-one

0.00000052

1-[1,3]oxazolo[4,5-b]pyridin-2-yl-9-phenylnonan-1-one

0.00000015

1-[1,3]oxazolo[4,5-b]pyridin-2-yldec-9-en-1-one

0.00000018

1-[1,3]oxazolo[4,5-b]pyridin-2-yldec-9-yn-1-one

0.00000075

1-[1,3]oxazolo[4,5-b]pyridin-2-yldecan-1-one

0.00000057

1-[1,3]oxazolo[4,5-b]pyridin-2-yldodecan-1-one

0.0000021

1-[1,3]oxazolo[4,5-b]pyridin-2-ylheptan-1-one

0.0000019

1-[1,3]oxazolo[4,5-b]pyridin-2-ylhexadecan-1-one

0.000015

1-[1,3]oxazolo[4,5-b]pyridin-2-ylhexan-1-one

0.00000014

1-[1,3]oxazolo[4,5-b]pyridin-2-yloctadec-9-yn-1-one

0.000011

1-[1,3]oxazolo[4,5-b]pyridin-2-yloctadecan-1-one

0.00000069

1-[1,3]oxazolo[4,5-b]pyridin-2-yloctan-1-one

0.00005

1-[1,3]oxazolo[4,5-b]pyridin-2-ylpentan-1-one

0.0000017

1-[1,3]oxazolo[4,5-b]pyridin-2-yltetradecan-1-one

0.000026

1-[5-(2,4-dimethoxypyrimidin-5-yl)-1,3-oxazol-2-yl]-7-phenylheptan-1-one

0.000005

1-[5-(2,6-dimethoxypyrimidin-4-yl)-1,3-oxazol-2-yl]-7-phenylheptan-1-one

0.00075

1-[5-(2-aminophenyl)-1,3-oxazol-2-yl]-7-phenylheptan-1-one

0.00011

1-[5-(2-fluorophenyl)-1,3-oxazol-2-yl]-7-phenylheptan-1-one

0.00017

1-[5-(2-hydroxyphenyl)-1,3-oxazol-2-yl]-7-phenylheptan-1-one

0.0004

1-[5-(2-methoxyphenyl)-1,3-oxazol-2-yl]-7-phenylheptan-1-one

0.00013

1-[5-(2-nitrophenyl)-1,3-oxazol-2-yl]-7-phenylheptan-1-one

0.000019

1-[5-(3-aminophenyl)-1,3-oxazol-2-yl]-7-phenylheptan-1-one

0.00005

1-[5-(3-fluorophenyl)-1,3-oxazol-2-yl]-7-phenylheptan-1-one

0.00005

1-[5-(3-hydroxyphenyl)-1,3-oxazol-2-yl]-7-phenylheptan-1-one

0.00004

1-[5-(3-methoxyphenyl)-1,3-oxazol-2-yl]-7-phenylheptan-1-one

0.000015

1-[5-(3-methylpyridin-2-yl)-1,3-oxazol-2-yl]-7-phenylheptan-1-one

0.000028

1-[5-(3-nitrophenyl)-1,3-oxazol-2-yl]-7-phenylheptan-1-one

0.00009

1-[5-(4-aminophenyl)-1,3-oxazol-2-yl]-7-phenylheptan-1-one

0.000025

1-[5-(4-aminopyridin-2-yl)-1,3-oxazol-2-yl]-7-phenylheptan-1-one

0.000062

1-[5-(4-fluorophenyl)-1,3-oxazol-2-yl]-7-phenylheptan-1-one

0.000002

1-[5-(4-fluoropyridin-2-yl)-1,3-oxazol-2-yl]-7-phenylheptan-1-one

0.00014

1-[5-(4-hydroxyphenyl)-1,3-oxazol-2-yl]-7-phenylheptan-1-one

0.0001

1-[5-(4-methoxyphenyl)-1,3-oxazol-2-yl]-7-phenylheptan-1-one

0.0000008

1-[5-(4-methoxypyridin-2-yl)-1,3-oxazol-2-yl]-7-phenylheptan-1-one

0.0000006

1-[5-(4-methylpyridin-2-yl)-1,3-oxazol-2-yl]-7-phenylheptan-1-one

0.00005

1-[5-(4-nitrophenyl)-1,3-oxazol-2-yl]-7-phenylheptan-1-one

0.0000032

1-[5-(4-nitropyridin-2-yl)-1,3-oxazol-2-yl]-7-phenylheptan-1-one

0.0000028

1-[5-(5-methylpyridin-2-yl)-1,3-oxazol-2-yl]-7-phenylheptan-1-one

0.0000033

1-[5-(6-methylpyridin-2-yl)-1,3-oxazol-2-yl]-7-phenylheptan-1-one

0.000025

1-[5-(methylsulfanyl)-1,3-oxazol-2-yl]-7-phenylheptan-1-one

0.000024

1-[5-(morpholin-4-ylcarbonyl)-1,3-oxazol-2-yl]-7-phenylheptan-1-one

0.00008

1-[5-[(4-methylpiperazin-1-yl)carbonyl]-1,3-oxazol-2-yl]-7-phenylheptan-1-one

0.000006

2-(7-phenylheptanoyl)-1,3-oxazole-5-carbaldehyde

0.0000004

2-(7-phenylheptanoyl)-1,3-oxazole-5-carbonitrile

0.000005

2-(7-phenylheptanoyl)-1,3-oxazole-5-carboxamide

0.00003

2-(7-phenylheptanoyl)-1,3-oxazole-5-carboxylic acid

0.0003

2-[2-(7-phenylheptanoyl)-1,3-oxazol-5-yl]benzamide

0.0015

2-[2-(7-phenylheptanoyl)-1,3-oxazol-5-yl]benzenesulfonamide

0.006

2-[2-(7-phenylheptanoyl)-1,3-oxazol-5-yl]benzoic acid

0.00013

2-[2-(7-phenylheptanoyl)-1,3-oxazol-5-yl]benzonitrile

0.0000011

2-[2-(7-phenylheptanoyl)-1,3-oxazol-5-yl]pyridine-4-carbonitrile

0.00005

2-[2-(7-phenylheptanoyl)-1,3-oxazol-5-yl]pyridine-4-carboxylic acid

0.000006

3-[2-(7-phenylheptanoyl)-1,3-oxazol-5-yl]benzamide

0.000002

3-[2-(7-phenylheptanoyl)-1,3-oxazol-5-yl]benzenesulfonamide

0.000005

3-[2-(7-phenylheptanoyl)-1,3-oxazol-5-yl]benzoic acid

0.000015

3-[2-(7-phenylheptanoyl)-1,3-oxazol-5-yl]benzonitrile

0.00016

4-(acetylamino)phenyl 2-(4-[[2-(trifluoromethyl)pyridin-4-yl]amino]phenyl)propanoate

pH 7.4, 37°C

712699

0.00001

4-[2-(7-phenylheptanoyl)-1,3-oxazol-5-yl]benzamide

0.00001

4-[2-(7-phenylheptanoyl)-1,3-oxazol-5-yl]benzenesulfonamide

0.00006

4-[2-(7-phenylheptanoyl)-1,3-oxazol-5-yl]benzoic acid

0.00004

4-[2-(7-phenylheptanoyl)-1,3-oxazol-5-yl]benzonitrile

0.000015

5-[2-(7-phenylheptanoyl)-1,3-oxazol-5-yl]furan-2-carboxylic acid

0.00035

5-[2-(7-phenylheptanoyl)-1,3-oxazol-5-yl]pyrimidine-2,4(1H,3H)-dione

0.000011

5-[2-(7-phenylheptanoyl)-1,3-oxazol-5-yl]thiophene-2-carboxylic acid

0.000003

5-[2-(7-phenylheptanoyl)-1,3-oxazol-5-yl]thiophene-2-sulfonamide

0.000001

6-[2-(7-phenylheptanoyl)-1,3-oxazol-5-yl]pyridine-2-carboxamide

0.00002

6-[2-(7-phenylheptanoyl)-1,3-oxazol-5-yl]pyridine-2-carboxylic acid

0.0000012

6-[2-(7-phenylheptanoyl)-1,3-oxazol-5-yl]pyridine-3-carboxamide

0.000007

6-[2-(7-phenylheptanoyl)-1,3-oxazol-5-yl]pyridine-3-carboxylic acid

0.000012

6-[2-(7-phenylheptanoyl)-1,3-oxazol-5-yl]pyrimidine-2,4(1H,3H)-dione

0.00008

7-phenyl-1-(5-phenyl-1,3-oxazol-2-yl)heptan-1-one

0.0000047

7-phenyl-1-(5-pyridin-2-yl-1,3-oxazol-2-yl)heptan-1-one

0.0000053

7-phenyl-1-(5-pyrimidin-2-yl-1,3-oxazol-2-yl)heptan-1-one

0.0000023

7-phenyl-1-(5-pyrimidin-4-yl-1,3-oxazol-2-yl)heptan-1-one

0.000022

7-phenyl-1-(5-pyrimidin-5-yl-1,3-oxazol-2-yl)heptan-1-one

0.000055

7-phenyl-1-(5-thiophen-2-yl-1,3-oxazol-2-yl)heptan-1-one

0.000063

7-phenyl-1-[5-(1H-tetrazol-5-yl)-1,3-oxazol-2-yl]heptan-1-one

0.000008

7-phenyl-1-[5-(piperidin-1-ylcarbonyl)-1,3-oxazol-2-yl]heptan-1-one

0.0000047

7-phenyl-1-[5-(pyridin-2-yl)-1,3-oxazol-2-yl]heptan-1-one

P97612

pH 9.0, 22°C

733501

0.00001

7-phenyl-1-[5-(thiomorpholin-4-ylcarbonyl)-1,3-oxazol-2-yl]heptan-1-one

0.000004

7-phenyl-1-[5-(trifluoroacetyl)-1,3-oxazol-2-yl]heptan-1-one

0.0000008

7-phenyl-1-[5-(trifluoromethyl)-1,3-oxazol-2-yl]heptan-1-one

0.005

7-phenyl-1-[5-[2-(trifluoroacetyl)phenyl]-1,3-oxazol-2-yl]heptan-1-one

0.000016

7-phenyl-1-[5-[3-(trifluoroacetyl)phenyl]-1,3-oxazol-2-yl]heptan-1-one

0.000065

7-phenyl-1-[5-[4-(trifluoroacetyl)phenyl]-1,3-oxazol-2-yl]heptan-1-one

0.0000035

7-phenyl-1-[5-[4-(trifluoromethyl)pyridin-2-yl]-1,3-oxazol-2-yl]heptan-1-one

0.0005

ethyl (10Z)-2-oxononadec-10-enoate

0.0000009

methyl 2-(7-phenylheptanoyl)-1,3-oxazole-5-carboxylate

0.00006

methyl 2-[2-(7-phenylheptanoyl)-1,3-oxazol-5-yl]benzoate

0.00013

methyl 2-[2-(7-phenylheptanoyl)-1,3-oxazol-5-yl]pyridine-3-carboxylate

0.0000013

methyl 2-[2-(7-phenylheptanoyl)-1,3-oxazol-5-yl]pyridine-4-carboxylate

0.000012

methyl 3-[2-(7-phenylheptanoyl)-1,3-oxazol-5-yl]benzoate

0.00004

methyl 4-[2-(7-phenylheptanoyl)-1,3-oxazol-5-yl]benzoate

0.0000055

methyl 5-[2-(7-phenylheptanoyl)-1,3-oxazol-5-yl]furan-2-carboxylate

0.000007

methyl 5-[2-(7-phenylheptanoyl)-1,3-oxazol-5-yl]thiophene-2-carboxylate

0.000008

methyl 6-[2-(7-phenylheptanoyl)-1,3-oxazol-5-yl]pyridine-2-carboxylate

0.0000035

methyl 6-[2-(7-phenylheptanoyl)-1,3-oxazol-5-yl]pyridine-3-carboxylate

0.000002

N,N-dimethyl-2-(7-phenylheptanoyl)-1,3-oxazole-5-carboxamide

0.0026

N-(4-hydroxy-2-methylphenyl) arachidonoyl amide

in the presence of fatty acid-free bovine serum albumin (0.125% w/v). In the absence of fatty acid-free bovine serum albumin, the IC50 value is reduced

664469

0.0021

N-(4-hydroxyphenyl)arachidonylamide

in the presence of fatty acid-free bovine serum albumin (0.125% w/v). In the absence of fatty acid-free bovine serum albumin, the IC50 value is reduced

664469

0.000007

N-methyl-2-(7-phenylheptanoyl)-1,3-oxazole-5-carboxamide