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3.5.1.99: fatty acid amide hydrolase

This is an abbreviated version!
For detailed information about fatty acid amide hydrolase, go to the full flat file.

Word Map on EC 3.5.1.99

Reaction

anandamide
+
H2O
=
arachidonic acid
 +
ethanolamine

Synonyms

AAH, anandamide amidohydrolase, AtFAAH, endocannabinoid-degrading enzyme, FA amide hydrolase, FAAH, FAAH-1, FAAH-2, fatty acid amide hydrolase, fatty-acid amide hydrolase, hFAAH, oleamide hydrolase

ECTree

     3 Hydrolases
         3.5 Acting on carbon-nitrogen bonds, other than peptide bonds
             3.5.1 In linear amides
                3.5.1.99 fatty acid amide hydrolase

Reference

topprint

Reference on EC 3.5.1.99 - fatty acid amide hydrolase

Please use the Reference Search for a specific query.
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REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Patricelli, M.P.; Lashuel, H.A.; Giang, D.K.; Kelly, J.W.; Cravatt, B.F.
Comparative characterization of wild type and transmembrane domain-deleted fatty acid amide hydrolase identification of the transmembrane domain as a site for oligomerization
Biochemistry
37
15177-15187
1998
Rattus norvegicus
Manually annotated by BRENDA team
Vandevoorde, S.; Fowler, C.J.
Inhibition of fatty acid amide hydrolase and monoacylglycerol lipase by the anandamide uptake inhibitor VDM11: evidence that VDM11 acts as an FAAH substrate
Br. J. Pharmacol.
145
885-893
2005
Rattus norvegicus, Rattus norvegicus Sprague-Dawley
Manually annotated by BRENDA team
Quistad, G.B.; Klintenberg, R.; Caboni, P.; Liang, S.N.; Casida, J.E.
Monoacylglycerol lipase inhibition by organophosphorus compounds leads to elevation of brain 2-arachidonoylglycerol and the associated hypomotility in mice
Toxicol. Appl. Pharmacol.
211
78-83
2006
Mus musculus
Manually annotated by BRENDA team
Cisneros, J.A.; Vandevoorde, S.; Ortega-Gutierrez, S.; Paris, C.; Fowler, C.J.; Lopez-Rodriguez, M.L.
Structure-activity relationship of a series of inhibitors of monoacylglycerol hydrolysis - comparison with effects upon fatty acid amide hydrolase
J. Med. Chem.
50
5012-5023
2007
Rattus norvegicus
Manually annotated by BRENDA team
Muccioli, G.G.; Xu, C.; Odah, E.; Cudaback, E.; Cisneros, J.A.; Lambert, D.M.; Lopez Rodriguez, M.L.; Bajjalieh, S.; Stella, N.
Identification of a novel endocannabinoid-hydrolyzing enzyme expressed by microglial cells
J. Neurosci.
27
2883-2889
2007
Mus musculus
Manually annotated by BRENDA team
Wei, B.Q.; Mikkelsen, T.S.; McKinney, M.K.; Lander, E.S.; Cravatt, B.F.
A second fatty acid amide hydrolase with variable distribution among placental mammals
J. Biol. Chem.
281
36569-36578
2006
Homo sapiens (O00519), Homo sapiens (Q6GMR7), Homo sapiens, Mus musculus (O08914), Mus musculus, Rattus norvegicus (P97612)
Manually annotated by BRENDA team
Fowler, C.J.; Jonsson, K.O.; Tiger, G.
Fatty acid amide hydrolase: biochemistry, pharmacology, and therapeutic possibilities for an enzyme hydrolyzing anandamide, 2-arachidonoylglycerol, palmitoylethanolamide, and oleamide
Biochem. Pharmacol.
62
517-26
2001
Homo sapiens, Mus musculus, Rattus norvegicus, Sus scrofa
Manually annotated by BRENDA team
Patricelli, M.P.; Cravatt, B.F.
Fatty acid amide hydrolase competitively degrades bioactive amides and esters through a nonconventional catalytic mechanism
Biochemistry
38
14125-14130
1999
Rattus norvegicus
Manually annotated by BRENDA team
Patricelli M.P.; Lovato, M.A.; Cravatt, B.F.
Chemical and mutagenic investigations of fatty acid amide hydrolase: evidence for a family of serine hydrolases with distinct catalytic properties
Biochemistry
38
9804-9812
1999
Rattus norvegicus
Manually annotated by BRENDA team
Patricelli, M.P.; Cravatt, B.F.
Characterization and manipulation of the acyl chain selectivity of fatty acid amide hydrolase
Biochemistry
40
6107-6115
2001
Rattus norvegicus
Manually annotated by BRENDA team
Ferreri, C.; Anagnostopoulos, D.; Lykakis, I.N.; Chatgilialoglu, C.; Siafaka-Kapadai, A.
Synthesis of all-trans anandamide: A substrate for fatty acid amide hydrolase with dual effects on rabbit platelet activation
Bioorg. Med. Chem.
16
8359-8365
2008
Oryctolagus cuniculus
Manually annotated by BRENDA team
Boger, D.L.; Fecik, R.A.; Patterson, J.E.; Miyauchi, H.; Patricelli, M.P.; Cravatt, B.F.
Fatty acid amide hydrolase substrate specificity
Bioorg. Med. Chem. Lett.
10
2613-2616
2000
Rattus norvegicus
Manually annotated by BRENDA team
Lodola, A.; Mor, M.; Hermann, J.C.; Tarzia, G.; Piomelli, D.; Mulholland, A.J.
QM/MM modelling of oleamide hydrolysis in fatty acid amide hydrolase (FAAH) reveals a new mechanism of nucleophile activation
Chem. Commun. (Camb. )
35
4399-401
2005
Rattus norvegicus
Manually annotated by BRENDA team
Patricelli, M.P.; Cravatt, B.F.
Clarifying the catalytic roles of conserved residues in the amidase signature family
J. Biol. Chem.
275
19177-19184
2000
Rattus norvegicus
Manually annotated by BRENDA team
Lang, W.; Qin, C.; Lin, S.; Khanolkar, A.D.; Goutopoulos, A.; Fan, P.; Abouzid, K.; Meng, Z.; Biegel, D.; Makriyannis, A.
Substrate specificity and stereoselectivity of rat brain microsomal anandamide amidohydrolase
J. Med. Chem.
42
898-902
1999
Rattus norvegicus
Manually annotated by BRENDA team
Romero, F.A.; Du, W.; Hwang, I.; Rayl, T.J.; Kimball, F.S.; Leung, D.; Hoover, H.S.; Apodaca, R.L.; Breitenbucher, J.G.; Cravatt, B.F.; Boger, D.L.J.
Potent and selective alpha-ketoheterocycle-based inhibitors of the anandamide and oleamide catabolizing enzyme, fatty acid amide hydrolase
J. Med. Chem.
50
1058-68
2007
Rattus norvegicus
Manually annotated by BRENDA team
Cravatt, B.F.; Giang, D.K.; Mayfield, S.P.; Boger, D.L.; Lerner, R.A.; Gilula, N.B.
Molecular characterization of an enzyme that degrades neuromodulatory fatty-acid amides
Nature
384
83-87
1996
Rattus norvegicus
Manually annotated by BRENDA team
Egertova, M.; Cravatt, B.F.; Elphick, M.R.
Fatty acid amide hydrolase expression in rat choroid plexus: possible role in regulation of the sleep-inducing action of oleamide
Neurosci. Lett.
282
13-16
2000
Rattus norvegicus
Manually annotated by BRENDA team
Giang, D.K.; Cravatt, B.F.
Molecular characterization of human and mouse fatty acid amide hydrolases
Proc. Natl. Acad. Sci. USA
94
2238-2242
1997
Rattus norvegicus, Homo sapiens (O00519), Homo sapiens, Mus musculus (O08914), Mus musculus
Manually annotated by BRENDA team
Boger, D.L.; Sato, H.; Lerner, A.E.; Hedrick, M.P.; Fecik, R.A.; Miyauchi, H.; Wilkie, G.D.; Austin, B.J.; Patricelli, M.P.; Cravatt, B.F.
Exceptionally potent inhibitors of fatty acid amide hydrolase: the enzyme responsible for degradation of endogenous oleamide and anandamide
Proc. Natl. Acad. Sci. USA
97
5044-5049
2000
Homo sapiens, Rattus norvegicus
Manually annotated by BRENDA team
Bracey, M.H.; Hanson, M.A.; Masuda, K.R.; Stevens, R.C.; Cravatt, B.F.
Structural adaptations in a membrane enzyme that terminates endocannabinoid signaling.
Science
298
1793-1796
2002
Rattus norvegicus (P97612)
Manually annotated by BRENDA team
Quistad, G.B.; Sparks, S.E.; Casida, J.E.
Fatty acid amide hydrolase inhibition by neurotoxic organophosphorus pesticides
Toxicol. Appl. Pharmacol.
173
48-55
2001
Mus musculus
Manually annotated by BRENDA team
Karbarz, M.J.; Luo, L.; Chang, L.; Tham, C.S.; Palmer, J.A.; Wilson, S.J.; Wennerholm, M.L.; Brown, S.M.; Scott, B.P.; Apodaca, R.L.; Keith, J.M.; Wu, J.; Breitenbucher, J.G.; Chaplan, S.R.; Webb, M.
Biochemical and biological properties of 4-(3-phenyl-[1,2,4] thiadiazol-5-yl)-piperazine-1-carboxylic acid phenylamide, a mechanism-based inhibitor of fatty acid amide hydrolase
Anesth. Analg.
108
316-329
2009
Rattus norvegicus, Homo sapiens (Q6GMR7), Homo sapiens
Manually annotated by BRENDA team
Kaczocha, M.; Glaser, S.T.; Chae, J.; Brown, D.A.; Deutsch, D.G.
Lipid droplets are novel sites of N-acylethanolamine inactivation by fatty acid amide hydrolase-2
J. Biol. Chem.
285
2796-2806
2010
Homo sapiens
Manually annotated by BRENDA team
Wyffels, L.; Muccioli, G.G.; De Bruyne, S.; Moerman, L.; Sambre, J.; Lambert, D.M.; De Vos, F.
Synthesis, in vitro and in vivo evaluation, and radiolabeling of aryl anandamide analogues as candidate radioligands for in vivo imaging of fatty acid amide hydrolase in the brain
J. Med. Chem.
52
4613-4622
2009
Mus musculus
Manually annotated by BRENDA team
Onnis, V.; Congiu, C.; Bjoerklund, E.; Hempel, F.; Soederstroem, E.; Fowler, C.J.
Synthesis and evaluation of paracetamol esters as novel fatty acid amide hydrolase inhibitors
J. Med. Chem.
53
2286-2298
2010
Rattus norvegicus
Manually annotated by BRENDA team
Lever, I.J.; Robinson, M.; Cibelli, M.; Paule, C.; Santha, P.; Yee, L.; Hunt, S.P.; Cravatt, B.F.; Elphick, M.R.; Nagy, I.; Rice, A.S.
Localization of the endocannabinoid-degrading enzyme fatty acid amide hydrolase in rat dorsal root ganglion cells and its regulation after peripheral nerve injury
J. Neurosci.
29
3766-3780
2009
Rattus norvegicus
Manually annotated by BRENDA team
Naidu, P.S.; Kinsey, S.G.; Guo, T.L.; Cravatt, B.F.; Lichtman, A.H.
Regulation of inflammatory pain by inhibition of fatty acid amide hydrolase
J. Pharmacol. Exp. Ther.
334
182-190
2010
Mus musculus
Manually annotated by BRENDA team
Glaser, S.T.; Kaczocha, M.
Temporal changes in mouse brain fatty acid amide hydrolase activity
Neuroscience
163
594-600
2009
Mus musculus
Manually annotated by BRENDA team
Rakers, C.; Zoerner, A.A.; Engeli, S.; Batkai, S.; Jordan, J.; Tsikas, D.
Stable isotope liquid chromatography-tandem mass spectrometry assay for fatty acid amide hydrolase activity
Anal. Biochem.
421
699-705
2012
Canis lupus familiaris, Homo sapiens
Manually annotated by BRENDA team
Tian, G.; Paschetto, K.A.; Gharahdaghi, F.; Gordon, E.; Wilkins, D.E.; Luo, X.; Scott, C.W.
Mechanism of inhibition of fatty acid amide hydrolase by sulfonamide-containing benzothiazoles: long residence time derived from increased kinetic barrier and not exclusively from thermodynamic potency
Biochemistry
50
6867-6878
2011
Homo sapiens, Rattus norvegicus
Manually annotated by BRENDA team
Gattinoni, S.; Simone, C.D.; Dallavalle, S.; Fezza, F.; Nannei, R.; Battista, N.; Minetti, P.; Quattrociocchi, G.; Caprioli, A.; Borsini, F.; Cabri, W.; Penco, S.; Merlini, L.; Maccarrone, M.
A new group of oxime carbamates as reversible inhibitors of fatty acid amide hydrolase
Bioorg. Med. Chem. Lett.
20
4406-4411
2010
Homo sapiens
Manually annotated by BRENDA team
Roughley, S.D.; Browne, H.; Macias, A.T.; Benwell, K.; Brooks, T.; D'Alessandro, J.; Daniels, Z.; Dugdale, S.; Francis, G.; Gibbons, B.; Hart, T.; Haymes, T.; Kennett, G.; Lightowler, S.; Matassova, N.; Mansell, H.; Merrett, A.; Misra, A.; Padfield, A.; Parsons, R.; Pratt, R.; Robertson, A.; Simmonite, H.; Tan, K.; Walls, S.B.; Wong, M.
Fatty acid amide hydrolase inhibitors. 3: tetra-substituted azetidine ureas with in vivo activity
Bioorg. Med. Chem. Lett.
22
901-906
2012
Homo sapiens, Rattus norvegicus
Manually annotated by BRENDA team
Zahov, S.; Drews, A.; Hess, M.; Schulze Elfringhoff, A.; Lehr, M.
1-(3-biaryloxy-2-oxopropyl)indole-5-carboxylic acids and related compounds as dual inhibitors of human cytosolic phospholipase A2alpha and fatty acid amide hydrolase
ChemMedChem
6
544-549
2011
Homo sapiens, Rattus norvegicus
Manually annotated by BRENDA team
Strittmatter, F.; Gandaglia, G.; Benigni, F.; Bettiga, A.; Rigatti, P.; Montorsi, F.; Gratzke, C.; Stief, C.; Colciago, G.; Hedlund, P.
Expression of fatty acid amide hydrolase (FAAH) in human, mouse, and rat urinary bladder and effects of FAAH inhibition on bladder function in awake rats
Eur. Urol.
61
98-106
2012
Homo sapiens, Mus musculus, Rattus norvegicus, Rattus norvegicus Sprague-Dawley
Manually annotated by BRENDA team
Mukhopadhyay, P.; Horvath, B.; Rajesh, M.; Matsumoto, S.; Saito, K.; Batkai, S.; Patel, V.; Tanchian, G.; Gao, R.Y.; Cravatt, B.F.; Hasko, G.; Pacher, P.
Fatty acid amide hydrolase is a key regulator of endocannabinoid-induced myocardial tissue injury
Free Radic. Biol. Med.
50
179-195
2011
Homo sapiens, Mus musculus, Mus musculus C57/BL6J
Manually annotated by BRENDA team
Teaster, N.D.; Keereetaweep, J.; Kilaru, A.; Wang, Y.S.; Tang, Y.; Tran, C.N.; Ayre, B.G.; Chapman, K.D.; Blancaflor, E.B.
Overexpression of fatty acid amide hydrolase induces early flowering in Arabidopsis thaliana
Front. Plant Sci.
3
32
2012
Arabidopsis thaliana (Q7XJJ7), Arabidopsis thaliana
Manually annotated by BRENDA team
Long, J.Z.; LaCava, M.; Jin, X.; Cravatt, B.F.
An anatomical and temporal portrait of physiological substrates for fatty acid amide hydrolase
J. Lipid Res.
52
337-344
2011
Mus musculus
Manually annotated by BRENDA team
Mileni, M.; Kamtekar, S.; Wood, D.C.; Benson, T.E.; Cravatt, B.F.; Stevens, R.C.
Crystal structure of fatty acid amide hydrolase bound to the carbamate inhibitor URB597: discovery of a deacylating water molecule and insight into enzyme inactivation
J. Mol. Biol.
400
743-754
2010
Rattus norvegicus (P97612)
Manually annotated by BRENDA team
Bouskila, J.; Burke, M.W.; Zabouri, N.; Casanova, C.; Ptito, M.; Bouchard, J.F.
Expression and localization of the cannabinoid receptor type 1 and the enzyme fatty acid amide hydrolase in the retina of vervet monkeys
Neuroscience
202
117-130
2012
Chlorocebus sabaeus
Manually annotated by BRENDA team
Min, X.; Thibault, S.T.; Porter, A.C.; Gustin, D.J.; Carlson, T.J.; Xu, H.; Lindstrom, M.; Xu, G.; Uyeda, C.; Ma, Z.; Li, Y.; Kayser, F.; Walker, N.P.; Wang, Z.
Discovery and molecular basis of potent noncovalent inhibitors of fatty acid amide hydrolase (FAAH)
Proc. Natl. Acad. Sci. USA
108
7379-7384
2011
Homo sapiens (O00519), Rattus norvegicus (P97612)
Manually annotated by BRENDA team
Kono, M.; Matsumoto, T.; Imaeda, T.; Kawamura, T.; Fujimoto, S.; Kosugi, Y.; Odani, T.; Shimizu, Y.; Matsui, H.; Shimojo, M.; Kori, M.
Design, synthesis, and biological evaluation of a series of piperazine ureas as fatty acid amide hydrolase inhibitors
Bioorg. Med. Chem.
22
1468-1478
2014
Homo sapiens (O00519), Rattus norvegicus (P97612), Rattus norvegicus Sprague-Dawley (P97612)
Manually annotated by BRENDA team
Duncan, K.K.; Otrubova, K.; Boger, D.L.
alpa-Ketoheterocycle inhibitors of fatty acid amide hydrolase: exploration of conformational constraints in the acyl side chain
Bioorg. Med. Chem.
22
2763-2770
2014
Rattus norvegicus (P97612)
Manually annotated by BRENDA team
Korhonen, J.; Kuusisto, A.; van Bruchem, J.; Patel, J.Z.; Laitinen, T.; Navia-Paldanius, D.; Laitinen, J.T.; Savinainen, J.R.; Parkkari, T.; Nevalainen, T.J.
Piperazine and piperidine carboxamides and carbamates as inhibitors of fatty acid amide hydrolase (FAAH) and monoacylglycerol lipase (MAGL)
Bioorg. Med. Chem.
22
6694-6705
2014
Homo sapiens (O00519)
Manually annotated by BRENDA team
Colombano, G.; Albani, C.; Ottonello, G.; Ribeiro, A.; Scarpelli, R.; Tarozzo, G.; Daglian, J.; Jung, K.M.; Piomelli, D.; Bandiera, T.
O-(triazolyl)methyl carbamates as a novel and potent class of fatty acid amide hydrolase (FAAH) inhibitors
ChemMedChem
10
380-395
2015
Homo sapiens (O00519), Homo sapiens, Rattus norvegicus (P97612), Rattus norvegicus Sprague–Dawley (P97612)
Manually annotated by BRENDA team
Cipriano, M.; Bjoerklund, E.; Wilson, A.A.; Congiu, C.; Onnis, V.; Fowler, C.J.
Inhibition of fatty acid amide hydrolase and cyclooxygenase by the N-(3-methylpyridin-2-yl)amide derivatives of flurbiprofen and naproxen
Eur. J. Pharmacol.
720
383-390
2013
Rattus norvegicus (P97612)
Manually annotated by BRENDA team
Caruano, J.; Feledziak, M.; Labar, G.; Michaux, C.; Perpete, E.A.; Muccioli, G.G.; Robiette, R.; Marchand-Brynaert, J.
(S)-1-(Pent-4-enoyl)-4-(hydroxymethyl)-azetidin-2-one derivatives as inhibitors of human fatty acid amide hydrolase (hFAAH): synthesis, biological evaluation and molecular modelling
J. Enzyme Inhib. Med. Chem.
29
654-662
2014
Homo sapiens (O00519), Homo sapiens
Manually annotated by BRENDA team
Alapafuja, S.O.; Nikas, S.P.; Bharathan, I.T.; Shukla, V.G.; Nasr, M.L.; Bowman, A.L.; Zvonok, N.; Li, J.; Shi, X.; Engen, J.R.; Makriyannis, A.
Sulfonyl fluoride inhibitors of fatty acid amide hydrolase
J. Med. Chem.
55
10074-10089
2012
Homo sapiens (O00519), Homo sapiens, Rattus norvegicus (P97612)
Manually annotated by BRENDA team
Dato, F.M.; Maassen, A.; Goldfuss, B.; Pietsch, M.
Characterization of fatty acid amide hydrolase activity by a fluorescence-based assay
Anal. Biochem.
546
50-57
2018
Homo sapiens
Manually annotated by BRENDA team
Sundermann, T.; Fabian, J.; Hanekamp, W.; Lehr, M.
1-Heteroaryl-3-phenoxypropan-2-ones as inhibitors of cytosolic phospholipase A2alpha and fatty acid amide hydrolase Effect of the replacement of the ether oxygen with sulfur and nitrogen moieties on enzyme inhibition and metabolic stability
Bioorg. Med. Chem.
23
2579-2592
2015
Rattus norvegicus (P97612)
Manually annotated by BRENDA team
Zahov, S.; Garzinsky, D.; Hanekamp, W.; Lehr, M.
1-Heteroarylpropan-2-ones as inhibitors of fatty acid amide hydrolase Studies on structure-activity relationships and metabolic stability
Bioorg. Med. Chem.
25
825-837
2017
Homo sapiens
Manually annotated by BRENDA team
Terwege, T.; Hanekamp, W.; Garzinsky, D.; Koenig, S.; Koch, O.; Lehr, M.
omega-Imidazolyl- and omega-tetrazolylalkylcarbamates as inhibitors of fatty acid amide hydrolase Biological activity and in vitro metabolic stability
ChemMedChem
11
429-443
2016
Rattus norvegicus (P97612)
Manually annotated by BRENDA team
Deplano, A.; Morgillo, C.M.; Demurtas, M.; Bjoerklund, E.; Cipriano, M.; Svensson, M.; Hashemian, S.; Smaldone, G.; Pedone, E.; Luque, F.J.; Cabiddu, M.G.; Novellino, E.; Fowler, C.J.; Catalanotti, B.; Onnis, V.
Novel propanamides as fatty acid amide hydrolase inhibitors
Eur. J. Med. Chem.
136
523-542
2017
Rattus norvegicus (P97612)
Manually annotated by BRENDA team
Watabiki, T.; Tsuji, N.; Kiso, T.; Ozawa, T.; Narazaki, F.; Kakimoto, S.
In vitro and in vivo pharmacological characterization of ASP8477 A novel highly selective fatty acid amide hydrolase inhibitor
Eur. J. Pharmacol.
815
42-48
2017
Homo sapiens (B2C6G4), Homo sapiens (O00519), Homo sapiens, Rattus norvegicus (P97612)
Manually annotated by BRENDA team
Giacovazzo, G.; Bisogno, T.; Piscitelli, F.; Verde, R.; Oddi, S.; Maccarrone, M.; Coccurello, R.
Different routes to inhibit fatty acid amide hydrolase do all roads lead to the same place?
Int. J. Mol. Sci.
20
E4503
2019
Mus musculus (O08914)
Manually annotated by BRENDA team
Althaus, J.; Hake, T.; Hanekamp, W.; Lehr, M.
1-(5-Carboxyindazol-1-yl)propan-2-ones as dual inhibitors of cytosolic phospholipase A2? and fatty acid amide hydrolase bioisosteric replacement of the carboxylic acid moiety
J. Enzyme Inhib. Med. Chem.
31
131-140
2016
Homo sapiens
Manually annotated by BRENDA team
Sundermann, T.; Hanekamp, W.; Lehr, M.
Structure-activity relationship studies on 1-heteroaryl-3-phenoxypropan-2-ones acting as inhibitors of cytosolic phospholipase A2alpha and fatty acid amide hydrolase replacement of the activated ketone group by other serine traps
J. Enzyme Inhib. Med. Chem.
31
653-663
2016
Homo sapiens
Manually annotated by BRENDA team
Sunduru, N.; Svensson, M.; Cipriano, M.; Marwaha, S.; Andersson, C.D.; Svensson, R.; Fowler, C.J.; Elofsson, M.
N-aryl 2-aryloxyacetamides as a new class of fatty acid amide hydrolase (FAAH) inhibitors
J. Enzyme Inhib. Med. Chem.
32
513-521
2017
Rattus norvegicus (P97612)
Manually annotated by BRENDA team
Deplano, A.; Cipriano, M.; Moraca, F.; Novellino, E.; Catalanotti, B.; Fowler, C.J.; Onnis, V.
Benzylamides and piperazinoarylamides of ibuprofen as fatty acid amide hydrolase inhibitors
J. Enzyme Inhib. Med. Chem.
34
562-576
2019
Rattus norvegicus (P97612)
Manually annotated by BRENDA team
Micoli, A.; De Simone, A.; Russo, D.; Ottonello, G.; Colombano, G.; Ruda, G.; Bandiera, T.; Cavalli, A.; Bottegoni, G.
Aryl and heteroaryl N-[4-[4-(2,3-substituted-phenyl)piperazine-1-yl]alkyl]carbamates with improved physico-chemical properties as dual modulators of dopamine D3 receptor and fatty acid amide hydrolase
MedChemComm
7
537-541
2016
Homo sapiens
-
Manually annotated by BRENDA team
Dahlhaus, H.; Hanekamp, W.; Lehr, M.
(Indolylalkyl)piperidine carbamates as inhibitors of fatty acid amide hydrolase (FAAH)
MedChemComm
8
616-620
2017
Rattus norvegicus (P97612)
Manually annotated by BRENDA team