3.5.1.99: fatty acid amide hydrolase
This is an abbreviated version!
For detailed information about fatty acid amide hydrolase, go to the full flat file.
Word Map on EC 3.5.1.99
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3.5.1.99
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endocannabinoids
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cannabinoids
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pain
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lipase
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agonist
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monoacylglycerol
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2-arachidonoylglycerol
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anxiety
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analgesic
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cannabis
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n-acylethanolamines
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vanilloid
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2-arachidonoyl
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ethanolamide
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palmitoylethanolamide
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carbamate
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rimonabant
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hyperalgesia
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reward
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tone
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nociceptive
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cannabimimetic
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n-arachidonoylethanolamine
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marijuana
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anxiolytic
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nape-pld
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antinociceptive
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oleoylethanolamide
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emotional
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neuropathic
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delta9-tetrahydrocannabinol
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amidase
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amygdalar
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medicine
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catalepsy
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pharmacology
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anti-allodynic
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anxiolytic-like
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monoglyceride
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cannabidiol
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psychoactive
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sleep-inducing
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phytocannabinoids
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anxiety-like
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arachidonyl
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monoacyl
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capsazepine
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aversive
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tetrahydrocannabinol
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drug development
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anti-hyperalgesic
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neuromodulatory
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fluorophosphonate
- 3.5.1.99
-
endocannabinoids
- cannabinoids
- pain
- lipase
- agonist
- monoacylglycerol
- 2-arachidonoylglycerol
-
anxiety
-
analgesic
- cannabis
- n-acylethanolamines
-
vanilloid
-
2-arachidonoyl
- ethanolamide
- palmitoylethanolamide
- carbamate
-
rimonabant
- hyperalgesia
-
reward
-
tone
-
nociceptive
-
cannabimimetic
- n-arachidonoylethanolamine
- marijuana
-
anxiolytic
- nape-pld
-
antinociceptive
- oleoylethanolamide
-
emotional
-
neuropathic
- delta9-tetrahydrocannabinol
- amidase
-
amygdalar
- medicine
- catalepsy
- pharmacology
-
anti-allodynic
-
anxiolytic-like
- monoglyceride
- cannabidiol
-
psychoactive
-
sleep-inducing
-
phytocannabinoids
-
anxiety-like
-
arachidonyl
-
monoacyl
-
capsazepine
-
aversive
- tetrahydrocannabinol
- drug development
-
anti-hyperalgesic
-
neuromodulatory
- fluorophosphonate
Reaction
Synonyms
AAH, anandamide amidohydrolase, AtFAAH, endocannabinoid-degrading enzyme, FA amide hydrolase, FAAH, FAAH-1, FAAH-2, fatty acid amide hydrolase, fatty-acid amide hydrolase, hFAAH, oleamide hydrolase
ECTree
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Natural Substrates Products on EC 3.5.1.99 - fatty acid amide hydrolase
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NATURAL SUBSTRATE 
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
2-arachidonoylglycerol + H2O
?
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FAAH is responsible for approximately one-half of the 2-arachidonoylglycerol hydrolysis occurring in BV-2 cell homogenate
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-
?
palmitoylethanolamide + H2O
palmitic acid + ethanolamine
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substrate of FAAH and FAAH-2, the latter shows lower activity than FAAH
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-
?
anandamide + H2O
arachidonic acid + ethanolamine
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i.e. arachidonoyl ethanolamide
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-
?
anandamide + H2O
arachidonic acid + ethanolamine
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substrate of FAAH and FAAH-2, the latter shows lower activity than FAAH
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-
?
anandamide + H2O
arachidonic acid + ethanolamine
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i.e. arachidonoyl ethanolamide
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-
?
anandamide + H2O
arachidonic acid + ethanolamine
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i.e. N-arachidonoyl ethanolamide
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-
?
anandamide + H2O
arachidonic acid + ethanolamine
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i.e. N-arachidonoylethanolamine
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-
?
anandamide + H2O
arachidonic acid + ethanolamine
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i.e. arachidonoyl ethanolamide
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-
?
anandamide + H2O
arachidonic acid + ethanolamine
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i.e. arachidonoyl ethanolamide
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-
?
anandamide + H2O
arachidonic acid + ethanolamine
i.e. arachidonoyl ethanolamide
-
-
?
anandamide + H2O
arachidonic acid + ethanolamine
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i.e. arachidonoyl ethanolamide
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-
?
anandamide + H2O
ethanolamine + arachidonic acid
FAAH-1 plays a primary role in regulating endocannabinoid signaling
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-
?
anandamide + H2O
ethanolamine + arachidonic acid
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anandamide hydrolysis in BV-2 cells is entirely attributable to FAAH
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-
?
anandamide + H2O
ethanolamine + arachidonic acid
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fatty acid amide hydrolase is a modulator of endogenous signaling compounds affecting sleep (oleamide) and analgesia (anandamide)
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-
?
anandamide + H2O
ethanolamine + arachidonic acid
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the enzyme cleaves anandamide and regulates in vivo the magnitude and duration of the signaling induced by this lipid messenger
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-
?
anandamide + H2O
ethanolamine + arachidonic acid
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-
-
?
anandamide + H2O
ethanolamine + arachidonic acid
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enzyme is responsible for the catabolism of neuromodulatory fatty acid amides, including anandamide and oleamide
-
-
?
anandamide + H2O
ethanolamine + arachidonic acid
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the enzyme is responsible for the hydrolysis of a number of neuromodulatory fatty acid amides, including the endogenous cannabinoid anandamide and the sleep-inducing lipid oleamide
-
-
?
anandamide + H2O
ethanolamine + arachidonic acid
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the serine hydrolase is responsible for the degradation of endogenous oleamide and anandamide, fatty acid amides that function as chemical messengers
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-
?
anandamide + H2O
ethanolamine + arachidonic acid
-
-
-
?
anandamide + H2O
ethanolamine + arachidonic acid
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-
-
?
N-arachidonoylethanolamine + H2O
arachidonic acid + ethanolamine
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-
-
?
N-arachidonoylethanolamine + H2O
arachidonic acid + ethanolamine
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-
-
?
N-arachidonoylethanolamine + H2O
arachidonic acid + ethanolamine
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-
-
?
oleamide + H2O
oleic acid + NH3
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fatty acid amide hydrolase is a modulator of endogenous signaling compounds affecting sleep (oleamide) and analgesia (anandamide)
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-
?
oleamide + H2O
oleic acid + NH3
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enzyme is responsible for the catabolism of neuromodulatory fatty acid amides, including anandamide and oleamide
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-
?
oleamide + H2O
oleic acid + NH3
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role of FAAH in epithelial cells of the choroid plexus may be to control the concentration of oleamide in the cerebrospinal fluid. FAAH may exert an important regulatory role in shaping the duration and magnitude of the sleep-inducing effect of endogenously or exogenously derived oleamide
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-
?
oleamide + H2O
oleic acid + NH3
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the enzyme is responsible for the hydrolysis of a number of neuromodulatory fatty acid amides, including the endogenous cannabinoid anandamide and the sleep-inducing lipid oleamide
-
-
?
oleamide + H2O
oleic acid + NH3
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the serine hydrolase is responsible for the degradation of endogenous oleamide and anandamide, fatty acid amides that function as chemical messengers
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-
?
additional information
?
-
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FAAH inactivates anandamide and other bioactive N-acylethanolamines
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-
?
additional information
?
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FAAH is the primary N-arachidonoylethanolamine-degrading enzyme, but it is also capable of hydrolyzing other bioactive N-acylethanolamines, such as N-palmitoylethanolamine, N-oleoylethanolamine and the sleep-inducing lipid oleamide
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-
?
