stimulates, binding of Mn2+ to the isolated cytoplasmic catalytic domain of the enzyme results in a significant alteration in the global conformation of the protein
a metal-dependent enzyme that is stimulated by divalent cations but shows no preference for Zn2+ unlike the mammalian homologue. It irreversibly loses activity upon incubation with a metal chelator. Fe2+ has no significant effect on the enzyme activity
a metal-dependent enzyme that is stimulated by divalent cations but shows no preference for Zn2+ unlike the mammalian homologue. It irreversibly loses activity upon incubation with a metal chelator. Fe2+ has no significant effect on the enzyme activity
the protein is active even in the absence of metal. The metal ion does not directly participate in ligand binding or recognition but is important for the catalytic efficiency of the enzymatic site