3.5.1.89: N-acetylglucosaminylphosphatidylinositol deacetylase

This is an abbreviated version!
For detailed information about N-acetylglucosaminylphosphatidylinositol deacetylase, go to the full flat file.

Reaction

Synonyms

2-acetamido-2-deoxy-alpha-D-glucopyranosyl-(1->6)-phosphatidylinositol de-N-acetylase, Acetylglucosaminylphosphatidylinositol deacetylase, alpha-D-GlcpNAc-PI de-N-acetylase, CaGpi12, Deacetylase, acetylglucosaminylphosphatidylinositol, deNAc, EC 3.1.1.69, GlcNAc-phosphatidylinositol deacetylase, GlcNAc-PI de-N-acetylase, GlcNAc-PI deacetylase, GlcNAc-PI-de-N-acetylase, GlcNAc-PI-deacetylase, GPI, GPI12, N-acetyl-D-glucosaminylphosphatidylinositol de-N-acetylase, N-acetylglucosamine-phosphatidylinositolde-N-acetylase, N-acetylglucosaminyl phosphatidylinositol de-N-acetylase, N-Acetylglucosaminylphosphatidylinositol de-N-acetylase, N-acetylglucosaminylphosphatidylinositol deacetylase, PIG-L, PIG-L protein, TbGPI12

ECTree

     3 Hydrolases

         3.5 Acting on carbon-nitrogen bonds, other than peptide bonds

             3.5.1 In linear amides

                3.5.1.89 N-acetylglucosaminylphosphatidylinositol deacetylase

Advanced search results

Do not include text mining results

Include results (more...)

Include results (more...)

Results	in table
3	Activating Compound
4581	AA Sequence
3	Application
1	CAS Registry Number
11	Cloned(Commentary)
15	Disease/ Diagnostics
25	General Information
2	General Stability
10	IC50 Value
86	Inhibitors
11	KM Value [mM]
10	Localization
32	Metals/Ions
2	Molecular Weight [Da]
8	Natural Substrates/ Products (Substrates)
30	Organism
2	Pathway
6	pH Optimum
1	pH Range
17	Protein Variants
3	Purification (Commentary)
2	Reaction
1	Reaction Type
30	Reference
16	Source Tissue
2	Storage Stability
48	Substrates and Products (Substrate)
4	Subunits
55	Synonyms
1	Systematic Name
4	Temperature Optimum [°C]

Disease

topprint

print visible entries

print all entries

Go back to the abbreviated version
of the Enzyme Summary Page.

Disease on EC 3.5.1.89 - N-acetylglucosaminylphosphatidylinositol deacetylase

Please use the Disease Search for a specific query.

Please wait a moment until all data is loaded. This message will disappear when all data is loaded.

Please wait a moment until the data is sorted. This message will disappear when the data is sorted.

DISEASE

TITLE OF PUBLICATION

LINK TO PUBMED

Thymoma

Subcellular localization and targeting of N-acetylglucosaminyl phosphatidylinositol de-N-acetylase, the second enzyme in the glycosylphosphatidylinositol biosynthetic pathway.

14742432

Trypanosomiasis, African

Cloning of Trypanosoma brucei and Leishmania major genes encoding the GlcNAc-phosphatidylinositol de-N-acetylase of glycosylphosphatidylinositol biosynthesis that is essential to the African sleeping sickness parasite.

12364327

Trypanosomiasis, African

Fragment screening reveals salicylic hydroxamic acid as an inhibitor of Trypanosoma brucei GPI GlcNAc-PI de-N-acetylase.

24589444

Trypanosomiasis, African

In silico drug re-purposing against African sleeping sickness using GlcNAc-PI de-N-acetylase as an experimental target.

26476127

Trypanosomiasis, African

Inhibitors incorporating zinc-binding groups target the GlcNAc-PI de-N-acetylase in Trypanosoma brucei, the causative agent of African sleeping sickness.

22222041

Trypanosomiasis, African

The N-acetyl-D-glucosaminylphosphatidylinositol De-N-acetylase of glycosylphosphatidylinositol biosynthesis is a zinc metalloenzyme.

15817455

html completed