3.5.1.89: N-acetylglucosaminylphosphatidylinositol deacetylase

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For detailed information about N-acetylglucosaminylphosphatidylinositol deacetylase, go to the full flat file.

Word Map on EC 3.5.1.89

3.5.1.89

glycosylphosphatidylinositol

trypanosomal

glcn-pi

sickness

gpi-anchored

de-n-acetylation

alpha-mannosyltransferase

medicine

mannosylated

drug development

Reaction

6-(N-acetyl-alpha-D-glucosaminyl)-1-phosphatidyl-1D-myo-inositol

6-(alpha-D-glucosaminyl)-1-phosphatidyl-1D-myo-inositol

Synonyms

2-acetamido-2-deoxy-alpha-D-glucopyranosyl-(1->6)-phosphatidylinositol de-N-acetylase, Acetylglucosaminylphosphatidylinositol deacetylase, alpha-D-GlcpNAc-PI de-N-acetylase, CaGpi12, Deacetylase, acetylglucosaminylphosphatidylinositol, deNAc, EC 3.1.1.69, GlcNAc-phosphatidylinositol deacetylase, GlcNAc-PI de-N-acetylase, GlcNAc-PI deacetylase, GlcNAc-PI-de-N-acetylase, GlcNAc-PI-deacetylase, GPI, GPI12, N-acetyl-D-glucosaminylphosphatidylinositol de-N-acetylase, N-acetylglucosamine-phosphatidylinositolde-N-acetylase, N-acetylglucosaminyl phosphatidylinositol de-N-acetylase, N-Acetylglucosaminylphosphatidylinositol de-N-acetylase, N-acetylglucosaminylphosphatidylinositol deacetylase, PIG-L, PIG-L protein, TbGPI12

ECTree

3 Hydrolases

3.5 Acting on carbon-nitrogen bonds, other than peptide bonds

3.5.1 In linear amides

3.5.1.89 N-acetylglucosaminylphosphatidylinositol deacetylase

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Results	in table
3	Activating Compound
4581	AA Sequence
3	Application
1	CAS Registry Number
11	Cloned(Commentary)
15	Disease/ Diagnostics
25	General Information
2	General Stability
10	IC50 Value
86	Inhibitors
11	KM Value [mM]
10	Localization
32	Metals/Ions
2	Molecular Weight [Da]
8	Natural Substrates/ Products (Substrates)
30	Organism
2	Pathway
6	pH Optimum
1	pH Range
17	Protein Variants
3	Purification (Commentary)
2	Reaction
1	Reaction Type
30	Reference
16	Source Tissue
2	Storage Stability
48	Substrates and Products (Substrate)
4	Subunits
55	Synonyms
1	Systematic Name
4	Temperature Optimum [°C]

IC50 Value

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IC50 Value on EC 3.5.1.89 - N-acetylglucosaminylphosphatidylinositol deacetylase

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1,5-anhydro-2-(carboxymethyl)-2-deoxy-D-glucitol

Trypanosoma brucei

IC50 above 10 mM, in 50 mM Na-HEPES pH 7.4, 25 mM KCl, 0.1 mM Tos-LysCH2Cl and 0.001 mg/ml leupeptin, at 30°C

719266

1,5-anhydro-2-deoxy-2-[2-(hydroxyamino)-2-oxoethyl]-D-glucitol

Trypanosoma brucei

IC50 above 10 mM, in 50 mM Na-HEPES pH 7.4, 25 mM KCl, 0.1 mM Tos-LysCH2Cl and 0.001 mg/ml leupeptin, at 30°C

719266

0.29

1,5-anhydro-3-O-benzyl-2-(carboxymethyl)-2-deoxy-D-glucitol

Trypanosoma brucei

in 50 mM Na-HEPES pH 7.4, 25 mM KCl, 0.1 mM Tos-LysCH2Cl and 0.001 mg/ml leupeptin, at 30°C

719266

1.5

1,5-anhydro-3-O-benzyl-2-deoxy-2-[2-(hydroxyamino)-2-oxoethyl]-D-glucitol

Trypanosoma brucei

in 50 mM Na-HEPES pH 7.4, 25 mM KCl, 0.1 mM Tos-LysCH2Cl and 0.001 mg/ml leupeptin, at 30°C

719266

0.3

2-(carboxymethyl)-2-deoxy-D-glucopyranose

Trypanosoma brucei

in 50 mM Na-HEPES pH 7.4, 25 mM KCl, 0.1 mM Tos-LysCH2Cl and 0.001 mg/ml leupeptin, at 30°C

719266

phenyl 2-(carbamoylamino)-2-deoxy-1-thio-beta-D-glucopyranoside

Trypanosoma brucei

IC50 above 10 mM, in 50 mM Na-HEPES pH 7.4, 25 mM KCl, 0.1 mM Tos-LysCH2Cl and 0.001 mg/ml leupeptin, at 30°C

719266

0.1 - 10

phenyl 2-(carboxymethyl)-2-deoxy-1-thio-alpha-D-glucopyranoside

2 entries

0.063

salicylic hydroxamic acid

Trypanosoma brucei

pH 8.0, 37°C

733611

0.019

triethylammonium 1R,2R-1-O-[2-C-(carboxymethyl N-hydroxyamide)-2-deoxy-beta-D-glucopyranosyl]-cyclohexanediol 2-(n-octadecylphosphate)

Trypanosoma brucei

in 50 mM Na-HEPES pH 7.4, 25 mM KCl, 0.1 mM Tos-LysCH2Cl and 0.001 mg/ml leupeptin, at 30°C

719266