3.5.1.89: N-acetylglucosaminylphosphatidylinositol deacetylase

This is an abbreviated version!
For detailed information about N-acetylglucosaminylphosphatidylinositol deacetylase, go to the full flat file.

Word Map on EC 3.5.1.89

3.5.1.89

glycosylphosphatidylinositol

trypanosomal

glcn-pi

sickness

gpi-anchored

de-n-acetylation

alpha-mannosyltransferase

medicine

mannosylated

drug development

Reaction

6-(N-acetyl-alpha-D-glucosaminyl)-1-phosphatidyl-1D-myo-inositol

6-(alpha-D-glucosaminyl)-1-phosphatidyl-1D-myo-inositol

Synonyms

2-acetamido-2-deoxy-alpha-D-glucopyranosyl-(1->6)-phosphatidylinositol de-N-acetylase, Acetylglucosaminylphosphatidylinositol deacetylase, alpha-D-GlcpNAc-PI de-N-acetylase, CaGpi12, Deacetylase, acetylglucosaminylphosphatidylinositol, deNAc, EC 3.1.1.69, GlcNAc-phosphatidylinositol deacetylase, GlcNAc-PI de-N-acetylase, GlcNAc-PI deacetylase, GlcNAc-PI-de-N-acetylase, GlcNAc-PI-deacetylase, GPI, GPI12, N-acetyl-D-glucosaminylphosphatidylinositol de-N-acetylase, N-acetylglucosamine-phosphatidylinositolde-N-acetylase, N-acetylglucosaminyl phosphatidylinositol de-N-acetylase, N-Acetylglucosaminylphosphatidylinositol de-N-acetylase, N-acetylglucosaminylphosphatidylinositol deacetylase, PIG-L, PIG-L protein, TbGPI12

ECTree

3 Hydrolases

3.5 Acting on carbon-nitrogen bonds, other than peptide bonds

3.5.1 In linear amides

3.5.1.89 N-acetylglucosaminylphosphatidylinositol deacetylase

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Results	in table
3	Activating Compound
4581	AA Sequence
3	Application
1	CAS Registry Number
11	Cloned(Commentary)
15	Disease/ Diagnostics
25	General Information
2	General Stability
10	IC50 Value
86	Inhibitors
11	KM Value [mM]
10	Localization
32	Metals/Ions
2	Molecular Weight [Da]
8	Natural Substrates/ Products (Substrates)
30	Organism
2	Pathway
6	pH Optimum
1	pH Range
17	Protein Variants
3	Purification (Commentary)
2	Reaction
1	Reaction Type
30	Reference
16	Source Tissue
2	Storage Stability
48	Substrates and Products (Substrate)
4	Subunits
55	Synonyms
1	Systematic Name
4	Temperature Optimum [°C]

Substrates Products

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Substrates Products on EC 3.5.1.89 - N-acetylglucosaminylphosphatidylinositol deacetylase

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(1R,2R)-1-O-(2-acetylamino-2-deoxy-alpha-D-glucopyranosyl)-cyclohexanediol 2-(1,2-di-O-hexadecanoyl-sn-glycerol 3-phosphate) + H2O

Trypanosoma brucei

734824

1-D-(2-amino-2-deoxy-alpha-D-glucopyranosyl)-myo-inositol 1-(1,2-di-O-hexadecanoyl-sn-glycerol 3-phosphate) + H2O

Trypanosoma brucei

734824

2-acetamido-2-deoxy-alpha-D-glucopyranosyl-(1->6)-phosphatidylinositol + H2O

6-(alpha-D-glucosaminyl)-1-phosphatidyl-1D-myo-inositol + acetate

Trypanosoma brucei

719226

6-(N-acetyl-alpha-D-glucosaminyl)-1-phosphatidyl-1D-myo-inositol + H2O

6-(alpha-D-glucosaminyl)-1-phosphatidyl-1D-myo-inositol + acetate

10 entries

6-(N-butanoyl-alpha-D-glucosaminyl)-1-phosphatidyl-1D-myo-inositol + H2O

6-(alpha-D-glucosaminyl)-1-phosphatidyl-1D-myo-inositol + butanoate

2 entries

6-(N-hexanoyl-alpha-D-glucosaminyl)-1-phosphatidyl-1D-myo-inositol + H2O

6-(alpha-D-glucosaminyl)-1-phosphatidyl-1D-myo-inositol + hexanoate

2 entries

6-(N-isobutanoyl-alpha-D-glucosaminyl)-1-phosphatidyl-1D-myo-inositol + H2O

6-(alpha-D-glucosaminyl)-1-phosphatidyl-1D-myo-inositol + isobutanoate

2 entries

6-(N-pentanoyl-alpha-D-glucosaminyl)-1-phosphatidyl-1D-myo-inositol + H2O

6-(alpha-D-glucosaminyl)-1-phosphatidyl-1D-myo-inositol + pentanoate

2 entries

6-(N-propionyl-alpha-D-glucosaminyl)-1-phosphatidyl-1D-myo-inositol + H2O

6-(alpha-D-glucosaminyl)-1-phosphatidyl-1D-myo-inositol + propionate

2 entries

D-GlcNAc-alpha(1->6)-D-myo-inositol-1-octadecyl phosphate + H2O

D-GlcN-alpha(1->6)-D-myo-inositol-1-octadecyl phosphate + acetate

Trypanosoma brucei

719266

D-GlcNAc-alpha1-6-D-myo-inositol-1-HPO4-3-sn-1,2-diacylglycerol + H2O

Homo sapiens

684885

N,N-diethylethanaminium 1-D-2-[(2-acetamido-2-deoxy-alpha-D-glucopyranosyl)oxy]-myo-inosityl octadecyl phosphate + H2O

Trypanosoma brucei

734824

N-acetyl-D-glucosamine-alpha-(1-6)-D-myo-inositol-1-octadecyl phosphate + H2O

D-glucosamine-alpha-(1-6)-D-myo-inositol-1-octadecyl phosphate + acetate

2 entries

N-Acetyl-D-glucosaminylphosphatidylinositol + H2O

Trypanosoma sp.

involved in the formation of the glycosylphosphatidylinositol membrane anchor of the trypanosome variant-surface glycoprotein

288963

N-Acetyl-D-glucosaminylphosphatidylinositol + H2O

D-Glucosaminylphosphatidylinositol + acetate

7 entries

N-acetyl-D-glucosaminylphosphatidylinositol + H2O + H2O

D-glucosaminylphosphatidylinositol + acetate

Trypanosoma brucei

719266

additional information

10 entries

synthesis of substrate analogues and substrate structure-activity analysis, molecular dynamics simulations, overview. (1R,2R)-1-O-(2-acetylamino-2-deoxy-beta-D-glucopyranosyl)-cyclohexanediol 2-(1,2-di-O-hexadecanoyl-sn-glycerol 3-phosphate) is neither a substrate nor an inhibitor. No recognition and activity with substrate analogues (1R,2R)-2-[(2-amino-2-deoxy-alpha-D-glucopyranosyl)oxy]cyclohexyl octadecyl phosphate, (1R,2R)-2-[(2-amino-2-deoxy-beta-D-glucopyranosyl)oxy]cyclohexyl octadecyl phosphate, (1R,2R)-1-O-(2-amino-2-deoxy-alpha-D-glucopyranosyl)-cyclohexanediol 2-(1,2-di-O-hexadecanoyl-sn-glycerol 3-phosphate), (1R,2R)-1-O-(2-amino-2-deoxy-beta-D-glucopyranosyl)-cyclohexanediol 2-(1,2-di-O-hexadecanoyl-sn-glycerol 3-phosphate), N-(1R,2R)-2-O-(2-amino-2-deoxy-beta-D-glucopyranosyl)-cyclohexyloctadecane-1-sulphonamide, N-(1R,2R)-2-O-(2-amino-2-deoxy-alpha-D-glucopyranosyl)-cyclohexyloctadecane-1-sulphonamide, and triethylammonium trans-2-(2-amino-3-hydroxypropoxy)-cyclohexyl n-octadecyl phosphate, as well as with (1R,2R)-2-[(2-acetylamino-2-deoxy-alpha-D-glucopyranosyl)oxy]cyclohexyl octadecyl phosphate, (1R,2R)-2-[(2-acetamido-2-deoxy-beta-D-glucopyranosyl)oxy]cyclohexyl octadecyl phosphate, (1R,2R)-1-O-(2-acetylamino-2-deoxy-beta-D-glucopyranosyl)-cyclohexanediol 2-(1,2-di-O-hexadecanoyl-sn-glycerol 3-phosphate), N-((1R,2R)-2-[(2-acetamido-2-deoxy-beta-D-glucopyranosyl)oxy]cyclohexyl)octadecane-1-sulfonamide, N-((1R,2R)-2-[(2-acetamido-2-deoxy-alpha-D-glucopyranosyl)oxy]cyclohexyl)octadecane-1-sulfonamide, and N,N-diethylethanaminium (1R,2R)-2-(2-acetamido-3-hydroxypropoxy)cyclohexyl octadecyl phosphate. The requirement for the presence of inositol 2-, 3-, 4-, and 5-OH groups for recognition by the enzyme is nuanced and may depend on the conformational flexibility of the substrate analogue. The glucosamine and the phospholipid moieties are essential for binding and, while the D-myo-inositol residue is the preferred aglycone for recognition by the enzyme, the dispensing of it entirely with a cyclohexanediol group is tolerated by the enzyme

734824