3.4.24.B11: ADAMTS1 endopeptidase

This is an abbreviated version!
For detailed information about ADAMTS1 endopeptidase, go to the full flat file.

Reaction

proteolytic degradation of proteins =

Synonyms

A Disintegrin And Metalloprotease with ThromboSpondin Repeats 1, a disintegrin and metalloprotease with thrombospondin-like motifs, a disintegrin and metalloproteinase with thrombospondin 1, a disintegrin and metalloproteinase with thrombospondin motifs, a disintegrin and metalloproteinase with thrombospondin motifs 1, a disintegrin and metalloproteinase with thrombospondin motifs-1, a disintegrin and metalloproteinase with thrombospondin repeats 1, a disintegrin-like and metalloproteinase domain with thrombospondin type I motifs-1, ADAM metallopeptidase, ADAM-metallopeptidase with thrombospondin type 1 motifs-1, ADAM-TS 1, ADAM-TS1, ADAMTS-1, ADAMTS1, ADAMTS1 matrix metalloproteinase, angiogenesis inhibitor, M12.222, METH-1, METH1, XADAMTS1, Xenopus ortholog of ADAMTS1

ECTree

     3 Hydrolases

         3.4 Acting on peptide bonds (peptidases)

             3.4.24 Metalloendopeptidases

                3.4.24.B11 ADAMTS1 endopeptidase

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Results	in table
8	Activating Compound
5	AA Sequence
16	Application
1	CAS Registry Number
19	Cloned(Commentary)
1	Crystallization (Commentary)
3935	Disease/ Diagnostics
9	Expression
10	General Information
26	Inhibitors
14	Localization
16	Metals/Ions
20	Molecular Weight [Da]
26	Natural Substrates/ Products (Substrates)
72	Organism
4	pH Optimum
7	Posttranslational Modification
12	Protein Variants
11	Purification (Commentary)
4	Reaction
14	Reaction Type
71	Reference
87	Source Tissue
1	Specific Activity [micromol/min/mg]
71	Substrates and Products (Substrate)
11	Subunits
104	Synonyms
5	Temperature Optimum [°C]

General Information

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General Information on EC 3.4.24.B11 - ADAMTS1 endopeptidase

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GENERAL INFORMATION

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

malfunction

Mus musculus

P97857

silencing of Adamts1 blocks the adverse effects of ethanol on collagen and elastin levels

734360

metabolism

Mus musculus

P97857

the enzyme is controlled by the FoxO1-sestrin 3-AMP-activated protein kinase signaling cascade and regulates ethanol-induced changes in collagen I and elastin levels

734360

physiological function

8 entries

physiological function

Homo sapiens

-

roles in angiogenesis and tumor biology, important regulatory factor of angiogenesis and tumor growth in prostate tumors

711590

physiological function

Mus musculus

-

ADAMTS1 has an impact on bone mineral density and is a potent regulator of bone remodeling. Adamts1 induces parathyroid hormone levels in females and reduces osteocalcin levels in males

720086

physiological function

Homo sapiens

Q9UHI8

the enzyme inhibits cell proliferation, migration, and tube formation. The enzyme also inhibits vascular endothelial growth factor receptor 3 signaling under vascular endothelial growth factor-C stimulation

733798

physiological function

Mus musculus

P97857

expression of ADAMTS1 increases in middle-aged and old wild-type mice compared with young, whereas in SPARC (i.e. secreted protein acidic and rich in cysteine) mice only old animals show increased ADAMTS1 expression. Levels of ADAMTS1 substrate versican decrease with age only in wild-type. SPARC treatment increases secretion of collagen I and ADAMTS1 (both the 110-kDa latent and 87-kDa active forms) into the conditioned media as well as the cellular expression of transforming growth factor-beta1-induced protein (Tgfbi) and phosphorylated Smad2

752441

physiological function

Homo sapiens

-

HT-1080 cells overexpressing ADAMTS-1 exhibit a significant decrease in cell proliferation and migration velocity, both in presence of hepatocyte growth factor. ADAMTS-1 overexpression disturbs c-Met activation upon hepatocyte growth factor stimulation. Downstream ERK1/2 and FAK signaling pathways are also influenced. ADAMTS-1 decreases the size of the fibrosarcospheres, both under normal conditions and in the presence of hepatocyte growth factor. In presence of hepatocyte growth factor, ADAMTS-1 overexpression in HT-1080 disrupts microtumors formation in vivo

753507

physiological function

Mus musculus

P97857

in Adamts1-deficient mice, alterations of organs like kidney, heart and aorta are found. In addition, the lack of ADAMTS1 differently affects lymphocyte and myeloid populations in the spleen and bone marrow. The substrate versican is altered the absence of the protease. the absence of ADAMTS1 creates a pro-inflammatory landscape, correlating with tumour blockade

755491

physiological function

Mus musculus

P97857

macrophages at sites of muscle injury induce activation of satellite cells via expression of Adamts1. Overexpression of Adamts1 in macrophages in vivo is sufficient to increase satellite cell activation and improve muscle regeneration in young mice. NOTCH1 is a target of ADAMTS1 metalloproteinase activity, which reduces Notch signaling, leading to increased satellite cell activation

754846

physiological function

Mus musculus

P97857

transgenic mice overexpressing ADAMTS-1 are similar to ADAMTS-1 wild-type mice pertaining collagen, elastin content and aortic diameter

755146