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3.4.24.B11: ADAMTS1 endopeptidase

This is an abbreviated version!
For detailed information about ADAMTS1 endopeptidase, go to the full flat file.

Word Map on EC 3.4.24.B11

Reaction

proteolytic degradation of proteins =

Synonyms

A Disintegrin And Metalloprotease with ThromboSpondin Repeats 1, a disintegrin and metalloprotease with thrombospondin-like motifs, a disintegrin and metalloproteinase with thrombospondin 1, a disintegrin and metalloproteinase with thrombospondin motifs, a disintegrin and metalloproteinase with thrombospondin motifs 1, a disintegrin and metalloproteinase with thrombospondin motifs-1, a disintegrin and metalloproteinase with thrombospondin repeats 1, a disintegrin-like and metalloproteinase domain with thrombospondin type I motifs-1, ADAM metallopeptidase, ADAM-metallopeptidase with thrombospondin type 1 motifs-1, ADAM-TS 1, ADAM-TS1, ADAMTS-1, ADAMTS1, ADAMTS1 matrix metalloproteinase, angiogenesis inhibitor, M12.222, METH-1, METH1, XADAMTS1, Xenopus ortholog of ADAMTS1

ECTree

     3 Hydrolases
         3.4 Acting on peptide bonds (peptidases)
             3.4.24 Metalloendopeptidases
                3.4.24.B11 ADAMTS1 endopeptidase

Natural Substrates Products

Natural Substrates Products on EC 3.4.24.B11 - ADAMTS1 endopeptidase

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NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
aggrecan + H2O
?
show the reaction diagram
Collagen type I + H2O
?
show the reaction diagram
-
-
-
-
?
proteins + H2O
peptides
show the reaction diagram
syndecan-4 + H2O
?
show the reaction diagram
ADAMTS1 cleaves the ectodomain of syndecan-4. The shedding of syndecan-4 by ADAMTS1 disrupts cell adhesion and promotes cell migration
-
-
?
versican + H2O
DPEAAE + ?
show the reaction diagram
-
ADAMTS-1 cleaves versican at the Glu441-Ala442 bond to generate a 70000 Da fragment termed DPEAAE
-
-
?
additional information
?
-