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3.4.24.B11: ADAMTS1 endopeptidase

This is an abbreviated version!
For detailed information about ADAMTS1 endopeptidase, go to the full flat file.

Word Map on EC 3.4.24.B11

Reaction

proteolytic degradation of proteins =

Synonyms

A Disintegrin And Metalloprotease with ThromboSpondin Repeats 1, a disintegrin and metalloprotease with thrombospondin-like motifs, a disintegrin and metalloproteinase with thrombospondin 1, a disintegrin and metalloproteinase with thrombospondin motifs, a disintegrin and metalloproteinase with thrombospondin motifs 1, a disintegrin and metalloproteinase with thrombospondin motifs-1, a disintegrin and metalloproteinase with thrombospondin repeats 1, a disintegrin-like and metalloproteinase domain with thrombospondin type I motifs-1, ADAM metallopeptidase, ADAM-metallopeptidase with thrombospondin type 1 motifs-1, ADAM-TS 1, ADAM-TS1, ADAMTS-1, ADAMTS1, ADAMTS1 matrix metalloproteinase, angiogenesis inhibitor, M12.222, METH-1, METH1, XADAMTS1, Xenopus ortholog of ADAMTS1

ECTree

     3 Hydrolases
         3.4 Acting on peptide bonds (peptidases)
             3.4.24 Metalloendopeptidases
                3.4.24.B11 ADAMTS1 endopeptidase

Cloned

Cloned on EC 3.4.24.B11 - ADAMTS1 endopeptidase

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CLONED (Commentary)
ORGANISM
UNIPROT
LITERATURE
3'-untranslated region
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adamts-1 gene maps to chromosome 16, region C3-C5, transient expression in COS-7 cells of FLAG-tagged wild-type and deletion mutants and mutant E386Q
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DNA and amino acid sequence determination and analysis, in itro translation, expression as His-tagged protein in Escherichia coli strain BL21
expressed in 293-T cells
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expressed in High-FiveTM insect cells with pIB/V5-His insect cell expression vector
expressed in HUVEC cells
expressed in MCF7TetOff neo cells
expressed in Saccharomyces cerevisiae
expressed in Saccharomyces cerevisiae strain CG-1945
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expressed in SaOS-2 cells
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expressed in Sf21 insect cells
expression as Myc-His-tagged wild-type and truncated mutant in 293T cell line
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expression in CHO cells
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expression of full-length wild-type enzyme in human embryonic kidney cell line 293T, expression of C-terminal region of the enzyme, corresponding to amino acid residues 549-951, in breast tumor derived cell line T47D
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expression of His-Myc-tagged wild-type enzyme and tagged mutant E385A, as well as truncated construct comprising the amino acid residues 549-951, in the carcinoma cell line T47D
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expression of His-tagged enzyme in insect cells via baculovirus infection
for overexpression experiments
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transient expression in HEK293 cells of FLAG- and His-tagged wild-type and deletion mutants, the majority of the recombinant protein is expressed in an active form without the proprotein domain
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