3.4.24.B11: ADAMTS1 endopeptidase

This is an abbreviated version!
For detailed information about ADAMTS1 endopeptidase, go to the full flat file.

Reaction

proteolytic degradation of proteins =

Synonyms

A Disintegrin And Metalloprotease with ThromboSpondin Repeats 1, a disintegrin and metalloprotease with thrombospondin-like motifs, a disintegrin and metalloproteinase with thrombospondin 1, a disintegrin and metalloproteinase with thrombospondin motifs, a disintegrin and metalloproteinase with thrombospondin motifs 1, a disintegrin and metalloproteinase with thrombospondin motifs-1, a disintegrin and metalloproteinase with thrombospondin repeats 1, a disintegrin-like and metalloproteinase domain with thrombospondin type I motifs-1, ADAM metallopeptidase, ADAM-metallopeptidase with thrombospondin type 1 motifs-1, ADAM-TS 1, ADAM-TS1, ADAMTS-1, ADAMTS1, ADAMTS1 matrix metalloproteinase, angiogenesis inhibitor, M12.222, METH-1, METH1, XADAMTS1, Xenopus ortholog of ADAMTS1

ECTree

     3 Hydrolases

         3.4 Acting on peptide bonds (peptidases)

             3.4.24 Metalloendopeptidases

                3.4.24.B11 ADAMTS1 endopeptidase

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Results	in table
8	Activating Compound
5	AA Sequence
16	Application
1	CAS Registry Number
19	Cloned(Commentary)
1	Crystallization (Commentary)
3935	Disease/ Diagnostics
9	Expression
10	General Information
26	Inhibitors
14	Localization
16	Metals/Ions
20	Molecular Weight [Da]
26	Natural Substrates/ Products (Substrates)
72	Organism
4	pH Optimum
7	Posttranslational Modification
12	Protein Variants
11	Purification (Commentary)
4	Reaction
14	Reaction Type
71	Reference
87	Source Tissue
1	Specific Activity [micromol/min/mg]
71	Substrates and Products (Substrate)
11	Subunits
104	Synonyms
5	Temperature Optimum [°C]

Activating Compound

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Activating Compound on EC 3.4.24.B11 - ADAMTS1 endopeptidase

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ACTIVATING COMPOUND

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

IMAGE

cytokine

Mus musculus

-

stimulation of gene expression in colon carcinoma cell line

651525

-

fibronectin

Homo sapiens

Q9UHI8

2fold enhancement of activity

669388

-

fibulin-1

Homo sapiens

Q9UHI8

4fold enhancement of activity with 0.001 mg at 1:1, 1:2, and 1:3 molar ratio in 50 mM Tris, pH 7.4, 10 mM CaCl2, 80 mM NaCl overnight at 37 °C

669388

-

interleukin-1

Mus musculus

-

stimulation of gene expression in colon carcinoma cell line

651525

-

MMP-15

Mus musculus

-

activates ADAMTS-1

720154

-

additional information

3 entries

-

additional information

Homo sapiens

Q9UHI8

higher enzyme expression in degenerated intervertebral discs

695958

-

additional information

Homo sapiens

-

higher expression level in metastatic foci compared with corresponding primary tumor

698148

-

additional information

Mus musculus

-

complex formation with alpha2-macroglobulin

651525

-