3.4.24.34: neutrophil collagenase
This is an abbreviated version!
For detailed information about neutrophil collagenase, go to the full flat file.
Word Map on EC 3.4.24.34
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3.4.24.34
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mmp-9
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metalloproteinases
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zymography
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metastasis
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timp-1
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endothelial
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angiogenesis
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necrosis
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artery
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fibrosis
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cartilage
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gelatinase
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gelatin
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osteoarthritis
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joint
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periodontal
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tnf
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arthritis
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plaque
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infarct
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vessel
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rheumatoid
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myocardial
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invasiveness
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plasminogen
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basement
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synovial
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chondrocytes
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gingival
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articular
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transwell
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mt1-mmp
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aortic
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aneurysm
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collagenolytic
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aggrecan
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matrigel
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atherosclerotic
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stromelysins
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signal-regulated
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erk
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crevicular
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doxycycline
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gelatinolytic
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matrix-degrading
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anti-invasive
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diagnostics
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disintegrin
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upa
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photoaging
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membrane-type
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medicine
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biotechnology
- 3.4.24.34
- mmp-9
- metalloproteinases
-
zymography
- metastasis
- timp-1
- endothelial
- angiogenesis
- necrosis
- artery
- fibrosis
- cartilage
- gelatinase
- gelatin
- osteoarthritis
- joint
- periodontal
- tnf
- arthritis
- plaque
- infarct
- vessel
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rheumatoid
- myocardial
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invasiveness
- plasminogen
-
basement
- synovial
- chondrocytes
- gingival
-
articular
-
transwell
- mt1-mmp
- aortic
- aneurysm
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collagenolytic
- aggrecan
- matrigel
- atherosclerotic
- stromelysins
-
signal-regulated
- erk
-
crevicular
- doxycycline
-
gelatinolytic
-
matrix-degrading
-
anti-invasive
- diagnostics
-
disintegrin
- upa
-
photoaging
-
membrane-type
- medicine
- biotechnology
Reaction
Cleavage of interstitial collagens in the triple helical domain. Unlike EC 3.4.24.7, interstitial collagenase, this enzyme cleaves type III collagen additional information slowly than type I =
Synonyms
collagenase-2, collagenases-8, EC 3.4.24.7, HNC, human neutrophil collagenase, matrix metalloproteinase, Matrix metalloproteinase 8, Matrix metalloproteinase-8, metalloproteinase-8, MetMMP-8, MMP-7, MMP-8, MMP8, neutrophil collagenase, neutrophil collagenase MMP-8, neutrophil interstitial collagenase, PheMMP-8, PMNL collagenase, PMNL-CL, polymorphonuclear leukocyte collagenase, whMMP-8
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biotechnology
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human MMP-8 is coupled to epoxy activated silica matrix in an immobilized enzyme reactor which is used for the online screening of known MMP-8 inhibitors in zonal chromatography and inhibition experiments
diagnostics
correlation of salivary levels of MMP-8 and periodontal parameters of chronic periodontitis establish MMP-8 as a noninvasive marker for the early diagnosis of chronic periodontitis
medicine
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design of anticancer or other drugs which should be highly selective for their particular MMP targets
medicine
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implicated in cancer, arthritis, joint destruction and Alzheimer's disease
medicine
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elevated MMP-8 in bronchoalveolar lavage fluid is a marker of acute lung inflammation, and perhaps a contributor to acute lung injury, but is not necessarily an indicator of a poor outcome
medicine
breast cancer cell lines MCF-7, SKBR-3, and MDA-MB-231 expressing wild-type MMP-8 reveal elevated levels of interleukins IL-6 and IL-8. This increase is mirrored at the mRNA level and is dependent on MMP-8 catalytic activity. Sustained expression of wild-type MMP-8 by breast cancer cells is non-permissive for long-term growth.In long-term culture of transfected MDA-MB-231 cells, expression of wild-type but not E198A mutant MMP-8 is lost, with IL-6 and IL-8 levels returning to base line
medicine
MMP-8 is critical for dexamethasone therapy in alkali-burned corneas under dry eye conditions. The anti-inflammatory effects of Dex are mediated through increased MMP-8 expression
medicine
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MMP-8 is critical for dexamethasone therapy in alkali-burned corneas under dry eye conditions. The anti-inflammatory effects of Dex are mediated through increased MMP-8 expression
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