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3.4.24.34: neutrophil collagenase

This is an abbreviated version!
For detailed information about neutrophil collagenase, go to the full flat file.

Word Map on EC 3.4.24.34

Reaction

Cleavage of interstitial collagens in the triple helical domain. Unlike EC 3.4.24.7, interstitial collagenase, this enzyme cleaves type III collagen additional information slowly than type I =

Synonyms

collagenase-2, collagenases-8, EC 3.4.24.7, HNC, human neutrophil collagenase, matrix metalloproteinase, Matrix metalloproteinase 8, Matrix metalloproteinase-8, metalloproteinase-8, MetMMP-8, MMP-7, MMP-8, MMP8, neutrophil collagenase, neutrophil collagenase MMP-8, neutrophil interstitial collagenase, PheMMP-8, PMNL collagenase, PMNL-CL, polymorphonuclear leukocyte collagenase, whMMP-8

ECTree

     3 Hydrolases
         3.4 Acting on peptide bonds (peptidases)
             3.4.24 Metalloendopeptidases
                3.4.24.34 neutrophil collagenase

Reference

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Reference on EC 3.4.24.34 - neutrophil collagenase

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REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Hasty, K.A.; Jeffrey, J.J.; Hibbs, M.S.; Welgus, H.G.
The collagen substrate specificity of human neutrophil collagenase
J. Biol. Chem.
262
10048-10052
1987
Homo sapiens
Manually annotated by BRENDA team
Hasty, K.A.; Pourmotabbed, T.F.; Goldberg, G.I.; Thompson, J.P.; Spinella, D.G.; Stevens, R.M.; Mainardi, C.L.
Human neutrophil collagenase. A distinct gene product with homology to other matrix metalloproteinases
J. Biol. Chem.
265
11421-11424
1990
Homo sapiens
Manually annotated by BRENDA team
Knäuper, S.; Krämer, S.; Reinke, H.; Tschesche, H.
Characterization and activation of procollagenase from human polymorphonuclear leucocytes. N-terminal sequence determination of the proenzyme and various proteolytically activated forms
Eur. J. Biochem.
189
295-300
1990
Homo sapiens
Manually annotated by BRENDA team
Fosang, A.J.; Last, K.; Neame, P.J.; Murphy, G.; Knäuper, S.; Tschesche, H.; Hughes, C.E.; Caterson, B.; Hardingham, T.E.
Neutrophil collagenase (MMP-8) cleaves at the aggrecanase site E373-A374 in the interglobular domain of cartilage aggrecan
Biochem. J.
304
347-351
1994
Homo sapiens
Manually annotated by BRENDA team
Fasciglione, G.F.; Marini, S.; D'Alessio, S.; Politi, V.; Coletta, M.
pH- and temperature-dependence of functional modulation in metalloproteinases. A comparison between neutrophil collagenase and gelatinases A and B
Biophys. J.
79
2138-2149
2000
Homo sapiens
Manually annotated by BRENDA team
Betz, M.; Huxley, P.; Davies, S.J.; Mushtaq, Y.; Pieper, M.; Tschesche, H.; Bode, W.; Gomis-Ruth, F.X.
1.8-A crystal structure of the catalytic domain of human neutrophil collagenase (matrix metalloproteinase-8) complexed with a peptidomimetic hydroxamate primed-side inhibitor with a distinct selectivity profile
Eur. J. Biochem.
247
356-363
1997
Homo sapiens
Manually annotated by BRENDA team
Arner, E.C.; Decicco, C.P.; Cherney, R.; Tortorella, M.D.
Cleavage of native cartilage aggrecan by neutrophil collagenase (MMP-8) is distinct from endogenous cleavage by aggrecanase
J. Biol. Chem.
272
9294-9299
1997
Homo sapiens
Manually annotated by BRENDA team
Marini, S.; Fasciglione, G.F.; de Sanctis, G.; D'Alessio, S.; Politi, V.; Coletta, M.
Cleavage of bovine collagen I by neutrophil collagenase MMP-8. Effect of pH on the catalytic properties as compared to synthetic substrates
J. Biol. Chem.
275
18657-18663
2000
Homo sapiens
Manually annotated by BRENDA team
Brandstetter, H.; Grams, F.; Glitz, D.; Lang, A.; Huber, R.; Bode, W.; Krell, H.W.; Engh, R.A.
The 1.8-A crystal structure of a matrix metalloproteinase 8-barbiturate inhibitor complex reveals a previously unobserved mechanism for collagenase substrate recognition
J. Biol. Chem.
276
17405-17412
2001
Homo sapiens
Manually annotated by BRENDA team
Gioia, M.; Fasciglione, G.F.; Marini, S.; D'Alessio, S.; De Sanctis, G.; Diekmann, O.; Pieper, M.; Politi, V.; Tschesche, H.; Coletta, M.
Modulation of the catalytic activity of neutrophil collagenase MMP-8 on bovine collagen I. Role of the activation cleavage and of the hemopexin-like domain
J. Biol. Chem.
277
23123-23130
2002
Homo sapiens
Manually annotated by BRENDA team
Graf von Roedern, E.; Brandstetter, H.; Engh, R.A.; Bode, W.; Grams, F.; Moroder, L.
Bis-substituted malonic acid hydroxamate derivatives as inhibitors of human neutrophil collagenase (MMP8)
J. Med. Chem.
41
3041-3047
1998
Homo sapiens
Manually annotated by BRENDA team
Matter, H.; Schwab, W.; Barbier, D.; Billen, G.; Haase, B.; Neises, B.; Schudok, M.; Thorwart, W.; Schreuder, H.; Brachvogel, V.; Lonze, P.; Weithmann, K.U.
Quantitative structure-activity relationship of human neutrophil collagenase (MMP-8) inhibitors using comparative molecular field analysis and X-ray structure analysis
J. Med. Chem.
42
1908-1920
1999
Homo sapiens (P22894), Homo sapiens
Manually annotated by BRENDA team
Gavuzzo, E.; Pochetti, G.; Mazza, F.; Gallina, C.; Gorini, B.; D'Alessio, S.; Pieper, M.; Tschesche, H.; Tucker, P.A.
Two crystal structures of human neutrophil collagenase, one complexed with a primed- and the other with an unprimed-side inhibitor: implications for drug design
J. Med. Chem.
43
3377-3385
2000
Homo sapiens (P22894), Homo sapiens
Manually annotated by BRENDA team
Brandstetter, H.; Engh, R.A.; Von Roedern, E.G.; Moroder, L.; Huber, R.; Bode, W.; Grams, F.
Structure of malonic acid-based inhibitors bound to human neutrophil collagenase. A new binding mode explains apparently anomalous data
Protein Sci.
7
1303-1309
1998
Homo sapiens
Manually annotated by BRENDA team
Wilson, W.R.; Schwalbe, E.C.; Jones, J.L.; Bell, P.R.; Thompson, M.M.
Matrix metalloproteinase 8 (neutrophil collagenase) in the pathogenesis of abdominal aortic aneurysm
Br. J. Surg.
92
828-833
2005
Homo sapiens
Manually annotated by BRENDA team
Khanna-Gupta, A.; Zibello, T.; Idone, V.; Sun, H.; Lekstrom-Himes, J.; Berliner, N.
Human neutrophil collagenase expression is C/EBP-dependent during myeloid development
Exp. Hematol.
33
42-52
2005
Homo sapiens
Manually annotated by BRENDA team
Fligiel, S.E.; Standiford, T.; Fligiel, H.M.; Tashkin, D.; Strieter, R.M.; Warner, R.L.; Johnson, K.J.; Varani, J.
Matrix metalloproteinases and matrix metalloproteinase inhibitors in acute lung injury
Hum. Pathol.
37
422-430
2006
Homo sapiens
Manually annotated by BRENDA team
Pelman, G.R.; Morrison, C.J.; Overall, C.M.
Pivotal molecular determinants of peptidic and collagen triple helicase activities reside in the S3 subsite of matrix metalloproteinase 8 (MMP-8): the role of hydrogen bonding potential of ASN188 and TYR189 and the connecting cis bond
J. Biol. Chem.
280
2370-2377
2005
Homo sapiens
Manually annotated by BRENDA team
Owen, C.A.; Hu, Z.; Lopez-Otin, C.; Shapiro, S.D.
Membrane-bound matrix metalloproteinase-8 on activated polymorphonuclear cells is a potent, tissue inhibitor of metalloproteinase-resistant collagenase and serpinase
J. Immunol.
172
7791-7803
2004
Homo sapiens, Mus musculus
Manually annotated by BRENDA team
Li, J.; Liao, E.Y.; Dai, R.C.; Wei, Q.Y.; Luo, X.H.
Effects of 17 beta-estradiol on the expression of interstitial collagenases-8 and -13 (MMP-8 and MMP-13) and tissue inhibitor of metalloproteinase-1 (TIMP-1) in ovariectomized rat osteoblastic cells
J. Mol. Histol.
35
723-731
2004
Rattus norvegicus, Rattus norvegicus Sprague-Dawley
Manually annotated by BRENDA team
Sulkala, M.; Tervahartiala, T.; Sorsa, T.; Larmas, M.; Salo, T.; Tjaederhane, L.
Matrix metalloproteinase-8 (MMP-8) is the major collagenase in human dentin
Arch. Oral Biol.
52
121-127
2007
Homo sapiens
Manually annotated by BRENDA team
Tuomainen, A.M.; Nyyssoenen, K.; Laukkanen, J.A.; Tervahartiala, T.; Tuomainen, T.P.; Salonen, J.T.; Sorsa, T.; Pussinen, P.J.
Serum matrix metalloproteinase-8 concentrations are associated with cardiovascular outcome in men
Arterioscler. Thromb. Vasc. Biol.
27
2722-2728
2007
Homo sapiens
Manually annotated by BRENDA team
Liu, K.Z.; Hynes, A.; Man, A.; Alsagheer, A.; Singer, D.L.; Scott, D.A.
Increased local matrix metalloproteinase-8 expression in the periodontal connective tissues of smokers with periodontal disease
Biochim. Biophys. Acta
1762
775-780
2006
Homo sapiens
Manually annotated by BRENDA team
Korpi, J.T.; Kervinen, V.; Maeklin, H.; Vaeaenaenen, A.; Lahtinen, M.; Laeaerae, E.; Ristimaeki, A.; Thomas, G.; Ylipalosaari, M.; Astroem, P.; Lopez-Otin, C.; Sorsa, T.; Kantola, S.; Pirilae, E.; Salo, T.
Collagenase-2 (matrix metalloproteinase-8) plays a protective role in tongue cancer
Br. J. Cancer
98
766-775
2008
Homo sapiens, Mus musculus
Manually annotated by BRENDA team
Wilson, W.R.; Anderton, M.; Schwalbe, E.C.; Jones, J.L.; Furness, P.N.; Bell, P.R.; Thompson, M.M.
Matrix metalloproteinase-8 and -9 are increased at the site of abdominal aortic aneurysm rupture
Circulation
113
438-445
2006
Homo sapiens
Manually annotated by BRENDA team
Gutierrez-Fernandez, A.; Inada, M.; Balbin, M.; Fueyo, A.; Pitiot, A.S.; Astudillo, A.; Hirose, K.; Hirata, M.; Shapiro, S.D.; Noel, A.; Werb, Z.; Krane, S.M.; Lopez-Otin, C.; Puente, X.S.
Increased inflammation delays wound healing in mice deficient in collagenase-2 (MMP-8)
FASEB J.
21
2580-2591
2007
Mus musculus, Mus musculus C57/BL6J
Manually annotated by BRENDA team
Pochetti, G.; Gavuzzo, E.; Campestre, C.; Agamennone, M.; Tortorella, P.; Consalvi, V.; Gallina, C.; Hiller, O.; Tschesche, H.; Tucker, P.A.; Mazza, F.
Structural insight into the stereoselective inhibition of MMP-8 by enantiomeric sulfonamide phosphonates
J. Med. Chem.
49
923-931
2006
Homo sapiens
Manually annotated by BRENDA team
Aschi, M.; Besker, N.; Re, N.; Pochetti, G.; Coletti, C.; Gallina, C.; Mazza, F.
Stereoselectivity by enantiomeric inhibitors of matrix metalloproteinase-8: new insights from molecular dynamics simulations
J. Med. Chem.
50
211-218
2007
Homo sapiens
Manually annotated by BRENDA team
Tester, A.M.; Cox, J.H.; Connor, A.R.; Starr, A.E.; Dean, R.A.; Puente, X.S.; Lopez-Otin, C.; Overall, C.M.
LPS responsiveness and neutrophil chemotaxis in vivo require PMN MMP-8 activity
PLoS ONE
2
e312
2007
Mus musculus
Manually annotated by BRENDA team
Marcaccini, A.M.; Novaes, A.B.; Meschiari, C.A.; Souza, S.L.; Palioto, D.B.; Sorgi, C.A.; Faccioli, L.H.; Tanus-Santos, J.E.; Gerlach, R.F.
Circulating matrix metalloproteinase-8 (MMP-8) and MMP-9 are increased in chronic periodontal disease and decrease after non-surgical periodontal therapy
Clin. Chim. Acta
409
117-122
2009
Homo sapiens
Manually annotated by BRENDA team
Tsai, W.C.; Hsu, C.C.; Chang, H.N.; Lin, Y.C.; Lin, M.S.; Pang, J.H.
Ibuprofen upregulates expressions of matrix metalloproteinase-1, -8, -9, and -13 without affecting expressions of types I and III collagen in tendon cells
J. Orthop. Res.
28
487-491
2010
Rattus norvegicus
Manually annotated by BRENDA team
Cuadrado, E.; Rosell, A.; Penalba, A.; Slevin, M.; Alvarez-Sabin, J.; Ortega-Aznar, A.; Montaner, J.
Vascular MMP-9/TIMP-2 and neuronal MMP-10 up-regulation in human brain after stroke: a combined laser microdissection and protein array study
J. Proteome Res.
8
3191-3197
2009
Homo sapiens
Manually annotated by BRENDA team
Williams, K.E.; Olsen, D.R.
Matrix metalloproteinase-1 cleavage site recognition and binding in full-length human type III collagen
Matrix Biol.
28
373-379
2009
Homo sapiens
Manually annotated by BRENDA team
Pradhan-Palikhe, P.; Vesterinen, T.; Tarkkanen, J.; Leivo, I.; Sorsa, T.; Salo, T.; Mattila, P.S.
Plasma level of tissue inhibitor of matrix metalloproteinase-1 but not that of matrix metalloproteinase-8 predicts survival in head and neck squamous cell cancer
Oral Oncol.
46
514-518
2010
Homo sapiens
Manually annotated by BRENDA team
Mazzini, F.; Nuti, E.; Petri, A.; Rossello, A.
Immobilization of matrix metalloproteinase 8 (MMP-8) for online drug screening
J. Chromatogr. B
879
756-762
2011
Homo sapiens
Manually annotated by BRENDA team
Quintero, P.A.; Knolle, M.D.; Cala, L.F.; Zhuang, Y.; Owen, C.A.
Matrix metalloproteinase-8 inactivates macrophage inflammatory protein-1 alpha to reduce acute lung inflammation and injury in mice
J. Immunol.
184
1575-1588
2010
Mus musculus
Manually annotated by BRENDA team
Flynn, B.; Bhole, A.; Saeidi, N.; Liles, M.; Dimarzio, C.; Ruberti, J.
Mechanical strain stabilizes reconstituted collagen fibrils against enzymatic degradation by mammalian collagenase matrix metalloproteinase 8 (MMP-8)
PLoS ONE
5
e12337
2010
Homo sapiens
Manually annotated by BRENDA team
Hsieh, C.H.; Liu, C.Y.; Hsieh, Y.J.; Tai, H.C.; Wang, L.Y.; Tsai, T.H.; Chen, Y.J.
Matrix metalloproteinase-8 mediates the unfavorable systemic impact of local irradiation on pharmacokinetics of anti-cancer drug 5-Fluorouracil
PLoS ONE
6
e21000
2011
Rattus norvegicus
Manually annotated by BRENDA team
Schubert-Unkmeir, A.; Konrad, C.; Slanina, H.; Czapek, F.; Hebling, S.; Frosch, M.
Neisseria meningitidis induces brain microvascular endothelial cell detachment from the matrix and cleavage of occludin: A role for MMP-8
PLoS Pathog.
6
1-15
2010
Homo sapiens
Manually annotated by BRENDA team
Fang, C.; Wen, G.; Zhang, L.; Lin, L.; Moore, A.; Wu, S.; Ye, S.; Xiao, Q.
An important role of matrix metalloproteinase-8 in angiogenesis in vitro and in vivo
Cardiovasc. Res.
99
146-155
2013
Mus musculus (O70138), Homo sapiens (P22894), Homo sapiens
Manually annotated by BRENDA team
Thirkettle, S.; Decock, J.; Arnold, H.; Pennington, C.; Jaworski, D.; Edwards, D.
Matrix metalloproteinase 8 (collagenase 2) induces the expression of interleukins 6 and 8 in breast cancer cells
J. Biol. Chem.
288
16282-16294
2013
Homo sapiens (P22894), Homo sapiens
Manually annotated by BRENDA team
Lee, E.; Han, J.; Woo, M.; Shin, J.; Park, E.; Kang, J.; Moon, P.; Baek, M.; Son, W.; Ko, Y.; Choi, J.; Kim, H.
Matrix metalloproteinase-8 plays a pivotal role in neuroinflammation by modulating TNF-alpha activation
J. Immunol.
193
2384-2393
2014
Mus musculus (O70138), Mus musculus, Homo sapiens (P22894)
Manually annotated by BRENDA team
Hedenbjoerk-Lager, A.; Hamberg, K.; Paeaekkoenen, V.; Tjaederhane, L.; Ericson, D.
Collagen degradation and preservation of MMP-8 activity in human dentine matrix after demineralization
Arch. Oral Biol.
68
66-72
2016
Homo sapiens (P22894), Homo sapiens
Manually annotated by BRENDA team
Daly, M.C.; Atkinson, S.J.; Varisco, B.M.; Klingbeil, L.; Hake, P.; Lahni, P.; Piraino, G.; Wu, D.; Hogan, S.P.; Zingarelli, B.; Wong, H.R.
Role of matrix metalloproteinase-8 as a mediator of injury in intestinal ischemia and reperfusion
FASEB J.
30
3453-3460
2016
Mus musculus (O70138), Mus musculus C57BL/6 (O70138)
Manually annotated by BRENDA team
Gupta, N.; Gupta, N.; Gupta, A.; Khan, S.; Bansal, N.
Role of salivary matrix metalloproteinase-8 (MMP-8) in chronic periodontitis diagnosis
Front. Med.
9
72-76
2015
Homo sapiens (P22894), Homo sapiens
Manually annotated by BRENDA team
Bian, F.; Wang, C.; Tukler-Henriksson, J.; Pflugfelder, S.C.; Camodeca, C.; Nuti, E.; Rossello, A.; Li, D.Q.; de Paiva, C.S.
MMP-8 is critical for dexamethasone therapy in alkali-burned corneas under dry eye conditions
J. Cell. Physiol.
231
2506-2516
2016
Mus musculus (O70138), Mus musculus, Mus musculus C57BL/6 (O70138)
Manually annotated by BRENDA team
Atkinson, S.J.; Varisco, B.M.; Sandquist, M.; Daly, M.N.; Klingbeil, L.; Kuethe, J.W.; Midura, E.F.; Harmon, K.; Opaka, A.; Lahni, P.; Piraino, G.; Hake, P.; Zingarelli, B.; Mortenson, J.E.; Wynn, J.L.; Wong, H.R.
Matrix metalloproteinase-8 augments bacterial clearance in a juvenile sepsis model
Mol. Med.
22
455-463
2016
Mus musculus (O70138), Mus musculus, Mus musculus C57BL/6 (O70138)
Manually annotated by BRENDA team
Han, J.; Lee, E.; Moon, E.; Ryu, J.; Choi, J.; Kim, H.
Matrix metalloproteinase-8 is a novel pathogenetic factor in focal cerebral ischemia
Mol. Neurobiol.
53
231-239
2016
Mus musculus (O70138)
Manually annotated by BRENDA team
Abu Bakar, A.R.; Ripen, A.M.; Merican, A.F.; Mohamad, S.B.
Enzymatic inhibitory activity of Ficus deltoidea leaf extract on matrix metalloproteinase-2, 8 and 9
Nat. Prod. Res.
33
1765-1768
2019
Homo sapiens (P22894)
Manually annotated by BRENDA team
McNiff, M.L.; Haynes, E.P.; Dixit, N.; Gao, F.P.; Laurence, J.S.
Thioredoxin fusion construct enables high-yield production of soluble, active matrix metalloproteinase-8 (MMP-8) in Escherichia coli
Protein Expr. Purif.
122
64-71
2016
Homo sapiens (P22894)
Manually annotated by BRENDA team